Pharmaceutical Forms
Mostrando 13-24 de 93 artigos, teses e dissertações.
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13. Simultaneous Quantification of Three Chemical Types Bioactive Compounds in Radix Isatidis and Its Relevant Pharmaceutical Dosage Forms by HPLC-DAD
A simple and rapid high performance liquid chromatography coupled with diode array detector (HPLC-DAD) method was developed for simultaneous quantification of three chemical types of bioactive compounds including an alkaloid (epigoitrin), six nucleosides (uracil, cytidine, hypoxanthine, uridine, guanosine and adenosine), and four phenylpropanoids (syringin,
J. Braz. Chem. Soc.. Publicado em: 2017-07
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14. Inclusion complex of amiodarone hydrochloride with cyclodextrins: preparation, characterization and dissolution rate evaluation
ABSTRACT This study aimed to improve the water solubility of amiodarone hydrochloride (AMH) via inclusion complexes with β-cyclodextrin, methyl-β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin. Inclusion complexes were developed by physical mixture, coevaporation, spray-drying and freeze-drying. Solid state analysis was performed using X-ray powder diffr
Braz. J. Pharm. Sci.. Publicado em: 22/06/2017
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15. Development and validation of alternative methods by non-aqueous acid-base titration and derivative ultraviolet spectrophotometry for quantification of sildenafil in raw material and tablets
Sildenafil citrate (SILC) is a potent phosphodiesterase-5 inhibitor used for erectile dysfunction and pulmonary hypertension. This study shows two simple, fast and alternative analytical methods for SILC determination by non-aqueous titration and by derivative ultraviolet spectrophotometry (DUS) in active pharmaceutical ingredient and/or dosage forms. The qu
Braz. J. Pharm. Sci.. Publicado em: 20/04/2017
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16. Engineering spray-dried rosemary extracts with improved physicomechanical properties: a design of experiments issue
ABSTRACT A 33 Box–Behnken design and Response Surface Methodology were performed to evaluate the influence of extract feed rate, drying air inlet temperature and spray nozzle airflow rate on the process yield, stability parameters (moisture content and water activity) and on several physicomechanical properties of spray-dried rosemary extracts. Powder yiel
Rev. bras. farmacogn.. Publicado em: 2017-04
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17. Analysis of spironolactone polymorphs in active pharmaceutical ingredients and their effect on tablet dissolution profiles
ABSTRACT Spironolactone (SPR) is a steroidal drug administered as a potassium-sparing diuretic for high blood pressure treatment. The drug shows incomplete gastrointestinal absorption due to its poor aqueous solubility. The physicochemical properties of SPR in crystal forms I and II suggest that differences in their aqueous solubility may lead to a lack of b
Braz. J. Pharm. Sci.. Publicado em: 2016-12
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18. Hypoglycemic effect of formulation containing hydroethanolic extract of Calophyllum brasiliense in diabetic rats induced by streptozotocin
ABSTRACT Diabetes mellitus is a chronic and severe metabolic dysfunction, it's slow and progressive evolution interferes directly in the metabolism of carbohydrates, fats and proteins, causing hyperglycemia, glycosuria, polydipsia, hyperlipidaemia, among others. The aim of this study was to evaluate the antidiabetic effect of hydroethanolic extract and granu
Rev. bras. farmacogn.. Publicado em: 2016-10
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19. Comparative study of Passiflora taxa leaves: I. A morpho-anatomic profile
AbstractDetermining the authenticity and quality of plant raw materials used in the formulation of herbal medicines, teas and cosmetics is essential to ensure their safety and efficacy for clinical use. Some Passiflora species are officially recognized in the pharmaceutical compendia of various countries and have therapeutic uses, particularly as sedatives a
Rev. bras. farmacogn.. Publicado em: 2015-08
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20. ANÁLISES FÍSICO-QUÍMICAS DE BIOFILMES DE SULFATO DE CONDROITOINA MODIFICADO
Numerous investigations are dedicated to the research and development of new polymer materials destined for innovation in pharmaceutical forms. The application of these technological resources has allowed the commercialization of new therapeutic systems for modified drug release. This investigation aimed to evaluate the association of modified chondroitin su
Quím. Nova. Publicado em: 2015-03
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21. Electrochemical studies of olmesartan medoxomil and its detection in pharmaceutical dosage forms and biological fluids by cathodic adsorptive stripping voltammetric method
As propriedades eletroquímicas da olmesartana (OLME) foram investigadas por voltametria cíclia (CV) e voltametria de pulso diferencial (DPV) em eletrodo de gota pendente de mercúrio (HMDE). Todos os estudos foram baseados no sinal de redução eletroquímica de OLME irreversível e controlada pela adsorção em aproximadamente -1,2 e -1,5 V vs. Ag/AgCl em
J. Braz. Chem. Soc.. Publicado em: 2014-05
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22. RP-HPLC method development and validation for estimation of rivaroxaban in pharmaceutical dosage forms
Rivaroxabana, fármaco anticoagulante, atua em um ponto crucial no processo de coagulação do sangue e impede a formação de coágulos sanguíneos. Neste estudo, desenvolveu-se método de RP-HPLC para a determinação de rivaroxabana em comprimidos (Xarelto ® (10 mg)). Utilizou-se coluna LC (250 x 4,6 mm) Phenomenex Luna C18 5 mm 100 Å a 40 ºC. Realizou
Braz. J. Pharm. Sci.. Publicado em: 2013-06
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23. Preparation and characterization of solid oral dosage forms containing soy isoflavones
Soy isoflavones have been extensively used for menopausal symptoms and prevention of hormone-related cancer, osteoporosis and cardiovascular diseases. Commercially available forms of isoflavones include supplements, capsules and tablets. However, the non-standardization of soy isoflavones extracts and different dissolution profiles of these solid dosage form
Rev. bras. farmacogn.. Publicado em: 01/02/2013
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24. Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
A reliable method using LC-UV to assay mometasone furoate (MF) in creams or nasal sprays using the same chromatographic conditions was set up. Methanol:water 80:20 (v/v) (1.0 mL min-1) was used as mobile phase. MF was detected at 248 nm and analyzed in a concentration range from 1.0 to 20.0 µg mL-1. The method provided acceptable theoretical plates, peak si
Química Nova. Publicado em: 2012