Set-up of a method using LC-UV to assay mometasone furoate in pharmaceutical dosage forms
AUTOR(ES)
Ourique, Aline Ferreira, Contri, Renata Vidor, Guterres, Silvia Stanisçuaski, Beck, Ruy Carlos Ruver, Pohlmann, Adriana Raffin, Melero, Ana, Schaefer, Ulrich F.
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2012
RESUMO
A reliable method using LC-UV to assay mometasone furoate (MF) in creams or nasal sprays using the same chromatographic conditions was set up. Methanol:water 80:20 (v/v) (1.0 mL min-1) was used as mobile phase. MF was detected at 248 nm and analyzed in a concentration range from 1.0 to 20.0 µg mL-1. The method provided acceptable theoretical plates, peak simmetry, peak tailing factor and peak resolution a short run (5 min). The method showed specificity, good linearity (r = 0.9999) and the quantification limit was 0.379 µg mL-1. Furthermore, the method was precise (RSD < 2.0%), accurate (recovery > 97%) and robust.
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