Hypoglycemic effect of formulation containing hydroethanolic extract of Calophyllum brasiliense in diabetic rats induced by streptozotocin
AUTOR(ES)
Carvalho, Helison de Oliveira, Souza, Belmira Silva Farias e, Santos, Igor Victor Ferreira dos, Resque, Rafael Lima, Keita, Hady, Fernandes, Caio Pinho, Carvalho, José Carlos Tavares
FONTE
Rev. bras. farmacogn.
DATA DE PUBLICAÇÃO
2016-10
RESUMO
ABSTRACT Diabetes mellitus is a chronic and severe metabolic dysfunction, it's slow and progressive evolution interferes directly in the metabolism of carbohydrates, fats and proteins, causing hyperglycemia, glycosuria, polydipsia, hyperlipidaemia, among others. The aim of this study was to evaluate the antidiabetic effect of hydroethanolic extract and granulated of Calophyllum brasiliense Cambess., Clusiaceae, species in diabetic rats as well as it's biochemical parameters. The results demonstrated that both the pharmaceutical forms, hydroethanolic extract and granulated, were able to reduce significantly (p < 0.001) hyperglycemia and glycosuria, in addition to improve polydipsia, polyuria, and weight loss. Treatments using hydroethanolic extract and granulated were also able to reduce significantly levels of triacylglycerides, cholesterol and low-density lipoprotein, as well as the transaminases, urea and creatinine levels. Therefore, it is concluded that these pharmaceutical forms have anti-diabetic effect and act improving the biochemical parameters, this effect is probably due to the high content of polyphenolic compounds found in the formulations.
Documentos Relacionados
- Hypoglycemic effect of okra aqueous extract on streptozotocin-induced diabetic rats
- Antihyperlipidemic effect of peucedanum pastinacifolium extract in streptozotocin-induced diabetic rats
- Study of dissolution profiles and desintegration of capsules containing the dried hydroethanolic extract of Calophyllum brasiliense
- Phytochemical screening and hypoglycemic activity of Carica papaya leaf in streptozotocin-induced diabetic rats
- Propolis effect on streptozotocin-induced diabetic rats