Respostas ao treinamento resistido em relação à densidade mineral óssea e marcadores ósseos no polimorfismo foki do gene receptor de vitamina D em idosas

AUTOR(ES)
DATA DE PUBLICAÇÃO

2010

RESUMO

The aim of this study was to determine the influence of the vitamin D receptor (VDR) gene FokI genotype on both bone mineral density (BMD) and bone markers (BM) response to resistive training (TR) in Brazilian postmenopausal women. Methods 235 postmenopausal women (66.6 5.5 years) were studied before and after six months of RT. A total of 44 subjects completed RT protocol (experimental group, EG) and 48 served as Control Group (CG). DNA was extracted from blood samples of all subjects and genotyping was performed at the VDR FokI locus to determine its association to training response. Total body, greater trochanter, femoral neck, and lumbar spinal (L2-L4) bone mineral density (BMD) were measured before and after training program using dual-energy X-ray absorptiometry and the intact human Osteocalcin (OC) was measured with an immunoenzymetric assay and serum of carboxiterminal telopeptide region of type I collagen (ICTP) was measured with a quantitative enzymeimmunoassay. Results The genotype distribution of FokI (FF: 42,7%; Ff: 45,3%; ff: 11,8%) was in agreement with the expected for Hardy-Weinbergs equilibrium. The biomarker of formation, OC, was significantly increased by training in Ff and ff genotypes in EG, and the biomarker of reabsorption, ICTP in EG, decreased significantly in FF genotype (-51.44%). On the other hand, in EG the ff genotype increased the ICTP (47.42%), and ff of CG showed a significantly decrease of -71.05%. In the EG, BMD of whole body, femoral neck, Wards triangle and lumbar spinal increased in ff genotype (2.05%, 3.53%, 6.97% e 1.53, respectively) when compared with CG. However, the CG decreased BMD of Wards triangle (-3.45%). Conversely, there was a significant increase in BMD of lumbar spinal (3.56%) in CG ff genotype. Conclusion These data indicate that VDR FokI genotype may influence the BMD (total body, Wards triangle and L2-L4) and the bone markers in response to strength training.

ASSUNTO(S)

strength training receptor da vitamina d bne mineral density treino resistido elderly foki polymorphism educacao fisica bone markers densidade mineral óssea vitamin d receptor polimorfismos foki marcadores ósseos idosas

ACESSO AO ARTIGO

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