Propriedades fisico-quimicas e biologicas de novos carbamatos com potencial atividade anticolinestecasica

AUTOR(ES)
DATA DE PUBLICAÇÃO

1993

RESUMO

This project studied the influence of the substituent in carbamates which have potentist anticholinesterase activity. Several physical chemical and biological properties such as the partition coefficient an toxicity, were measured. Other properties such as molecular geometry, dipole moment, ionization potential and charge density, were estimated from theoretical considerations using the QSAR (Quantitative structure-Activity Rela - tionship) program. Correlations between the theoretical and measured properties are proposed for the ortho substitutes 3-N , N dimethylamino-phenyl-N,N-dimethylcarbamates. The additive method for calculating the coefficient presents a reasonable correlation, considering the electronic and hydrophobic effects of the substituents on the carbamate group. Analysis of the correlation coefficient suggest that electronic and steric effects have a more important influence, compared to the hydrophobic effects, in relation to anticholinesterase activity.

ASSUNTO(S)

farmacologia quimica farmaceutica

ACESSO AO ARTIGO

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