"Determinação de alvos antigênicos na doença reumática cardíaca utilizando phage display" / Identification of molecular markers involved in the pathogenesis of rheumatic heart disease by phage display

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Rheumatic heart disease (RHD) patients develop valvar lesions with CD4+ T lymphocytes infiltrating the heart. Molecular mimicry between streptococcal and cardiac proteins recognized by these T cells may explain these auto-aggressive lesions. In the present work we used a Phage Display peptide library to identify cardiac antigens which could be recognized by two heart infiltrate T cell lines and by a T cell clone derived from one of the lines which were isolated from RHD patients. Using the protein data bank to analyse the phage peptides, we observed that many sequences showed homology with cardiac myosin, laminin, vimentin and other coiled-coil proteins, suggesting the involvement of these proteins in the autoimmune process of RHD. Other inflammatory molecules such as cytokines and integrins were also identified

ASSUNTO(S)

febre reumática/imunologia molecular mimicry peptide library rheumatic fever/immunology streptococcus pyogenes mimetismo molecular biblioteca de peptídeos streptococcus pyogenes

ACESSO AO ARTIGO

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