Peptide Library
Mostrando 1-12 de 796 artigos, teses e dissertações.
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1. Anticorpo policlonal de ovinos para mapear mimetopos de Haemonchus contortus usando a biblioteca de Phage display
Resumo O objetivo deste estudo foi avaliar a tecnologia de phage display no mapeamento de mimetopos de Haemonchus contortus. Anticorpo policlonal de ovinos anti-H. contortus foi usado para seleção a partir da biblioteca PhD-7 Phage Display Peptide Library Kit (New England BioLabs). Após quatro rodadas, 50 clones de fagos expressando peptídeos foram sele
Rev. Bras. Parasitol. Vet.. Publicado em: 24/05/2018
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2. Cloning and purification of the first termicin-like peptide from the cockroach Eupolyphaga sinensis
Abstract Background Termicin is an antimicrobial peptide with six cysteines forming three disulfide bridges that was firstly isolated from the salivary glands and hemocytes of the termite Pseudacanthotermes spiniger. In contrast to many broad-spectrum antimicrobial peptides, termicin is most active against filamentous fungi. Although more than one hundred
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 19/02/2016
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3. A comparison between the recombinant expression and chemical synthesis of a short cysteine-rich insecticidal spider peptide
Abstract Background: The choice between heterologous expression versus chemical synthesis for synthesizing short cysteine-rich insecticidal peptides from arthropods may impact the obtainment of yields and well-folded bioactive molecules for scientific research. Therefore, two recombinant expression systems were compared to
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 11/08/2015
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4. Mimotopes selected by biopanning with high-titer HIV-neutralizing antibodies in plasma from Chinese slow progressors
OBJECTIVE: One approach to identifying HIV-1 vaccine candidates is to dissect the natural antiviral immune response in treatment-naïve individuals infected for over ten years, considered slow progressor patients (SPs). It is suspected that SP plasma has strongly neutralizing antibodies (NAb) targeting specific HIV viral epitopes. METHODS: NAbs levels of 11
Braz J Infect Dis. Publicado em: 2012-12
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5. Comparison of two peptide radiotracers for prostate carcinoma targeting
OBJECTIVES: Scintigraphy is generally not the first choice treatment for prostate cancer, although successful studies using bombesin analog radiopeptides have been performed. Recently, a novel peptide obtained using a phage display library demonstrated an affinity for prostate tumor cells. The aim of this study was to compare the use of a bombesin analog to
Clinics. Publicado em: 2012
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6. Isolamento e identificação de mimetopos de auto-antígenos para utilização em imunodiagnóstico da artrite idiopática juvenil
CHAPTER 2: Juvenile Idiopathic Arthritis (JIA) is a set of chronic diseases characterized by persistent inflammation of joints. "Idiopathic" means that no one knows the cause of illness and "Juvenile" in this case means that the onset of symptoms occurs before 16 years of age. The diagnosis of JIA is clinical and is based on the finding of arthritis in one o
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/06/2011
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7. Caracterização de proteinases envolvidas na geração de peptídeos antimicrobianos no intestino de Rhipicephalus (Boophilus) microplus. / CE. Characterization of proteinases involved in the generation of antimicrobial peptides in the gut of Rhipicephalus (Boophilus) microplus.
It is known that hemoglobin is a rich source of antimicrobial peptides (hemocidins). The first hemoglobin-derived hemocidin characterized in ticks was the peptide Hb33-61, which is active against Gram-positive bacteria and fungi. It is believed that hemocidins are endogenously generated in the tick gut. In this work we biochemically characterized a cathepsin
Publicado em: 2010
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8. Identification and characterization of involved molecules in the interaction of paracoccidioides brasiliensis with the host / Identificação e caracterização de moléculas envolvidas na interação de Paracoccidioides brasiliensis com o hospedeiro
Paracoccidioides brasiliensis causes paracoccidioidomycosis (PCM), a systemic mycosis presenting clinical manifestations ranging from mild to severe forms. A P. brasiliensis cDNA expression library was produced and screened with pooled sera from PCM patients adsorbed against antigens derived from in vitro-grown P. brasiliensis yeast cells. Sequencing DNA ins
Publicado em: 2009
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9. Identification and characterization of involved molecules in the interaction of paracoccidioides brasiliensis with the host / Identificação e caracterização de moléculas envolvidas na interação de Paracoccidioides brasiliensis com o hospedeiro
Paracoccidioides brasiliensis causes paracoccidioidomycosis (PCM), a systemic mycosis presenting clinical manifestations ranging from mild to severe forms. A P. brasiliensis cDNA expression library was produced and screened with pooled sera from PCM patients adsorbed against antigens derived from in vitro-grown P. brasiliensis yeast cells. Sequencing DNA ins
Publicado em: 2009
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10. Identificação de marcadores moleculares para células T reguladoras humanas com perfil CD4+CD25+ por phage display / Peptide phage display for the identification of novel molecular markers on human thymic regulatory CD4+CD25+ T cells
There are consistent data in literature indicating that thymic CD4+CD25+ cells play an important role in immune regulation and are continuously developed as an independent lineage in the thymus. These cells are known as natural regulatory T cells. Several questions about these cells remain unanswered, such as how they are generated, what is determinant in th
Publicado em: 2008
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11. Seleção e caracterização de peptídeos recombinantes ligantes a anticorpos monoclonais reativos a proteínas de Anaplasma marginale
Bovine anaplasmosis is caused by Anaplasma marginale and A. centrale. The most pathogenic and important species for cattle production is A. marginale, and is widely distributed in tropical, subtropical and temperate regions of the world. A. marginale is an intra-erythrocyte rickettsia of susceptible ruminants, biological and mechanically transmitted by ticks
Publicado em: 2008
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12. Construção da biblioteca de cDNA da glândula de peçonha do escorpião Opisthacanthus cayaporum e clonagem de genes que codificam para componentes da peçonha
A peçonha de escorpiões é uma complexa mistura de peptídeos que modulam canais iônicos, antimicrobianos, potencializadores de bradicinina, hemolíticos, e com outras atividades biológicas, sendo importante alvo de estudos para o desenvolvimento de novos fármacos. Os estudos de caracterização proteômica, principalmente com escorpiões da família Bu
Publicado em: 2008