Valproic Acid
Mostrando 1-12 de 46 artigos, teses e dissertações.
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1. Mixed Ternary Mononuclear Copper(II) Complexes Based on Valproic Acid with 1,10-Phenanthroline and 2,2'-Bipyridine Ligands: DNA Interaction and Cytotoxicity in V79 Cells
This paper reports the DNA interaction and cytotoxicity of binary and ternary copper(II) complexes of valproic acid with phenanthroline or bipyridine and the complementary characterization of Cu(Valp)2Bipy by crystallography. Circular dichroism, plasmid and oligonucleotide assays have shown that the complexes interact with DNA in different manners and are ab
J. Braz. Chem. Soc.. Publicado em: 2019-03
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2. Deformation of Mitochondrial Cristae in Human Neural Progenitor Cells Exposed to Valproic Acid
ABSTRACT Neural development represents a dynamic process where mitochondrial integrity is decisive for neuronal activity. Structural changes in these organelles may be related to neurological disorders. Valproic acid (VPA) is an anticonvulsive drug commonly used for epilepsy treatment and its use is associated to increased risk of neuropsychiatric disorders.
An. Acad. Bras. Ciênc.. Publicado em: 23/04/2018
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3. Valproic acid inhibits the invasion of PC3 prostate cancer cells by upregulating the metastasis suppressor protein NDRG1
Abstract Valproic acid (VPA) is a clinically available histone deacetylase inhibitor with promising anticancer attributes. Recent studies have demonstrated the anticancer effects of VPA on prostate cancer cells. However, little is known about the differential effects of VPA between metastatic and non-metastatic prostate cancer cells and the relationship betw
Genet. Mol. Biol.. Publicado em: 2015-12
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4. Desenvolvimento, caracterização físico-química e avaliação farmacocinética de nanopartículas auto-organizadas de quitosana / Development, physico-chemical characterization and pharmacokinetic evaluation of self-assembly chitosan nanoparticules
Objectives: Nanoparticles (NP) are useful to modulate the pharmacokinetics (PK) of drugs. The aim of this study was to develop innovative self-assembly nanovesicles (NV) constituted of chitosan and lecithin with isopropyl myristate (IPM) as oil core, able to modify the PK plasma profile of clozapine (CZP) and valproic acid (VPA). Methods: The NV were obtaine
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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5. Use of chromatin modifying agents in bovine somatic cell nuclear transfer / Uso de agentes modificadores de cromatina na transferência nuclear de células somáticas em bovinos
Embora a transferência nuclear de células somáticas (TNCS) seja uma ferramenta promissora, seu amplo uso é impedido devido às altas taxas de mortalidade durante o desenvolvimento dos animais clonados. Acredita-se que a reprogramação epigenética anormal seja a principal causa desta baixa eficiência. Nós hipotetizamos que agentes modificadores de cro
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/12/2011
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6. Validação psicométrica da versão português-Brasil do Liverpool Adverse Events Profile (LAEP) em pacientes com epilepsia parcial sintomática e epilepsia generalizada idiopática. / Psychometric Validation of the Portuguese-Brazilian Version of the Liverpool Adverse Events Profile in Patients with Symptomatic Partial and Idiopathic Generalized Epilepsies
Purpose: To report the translation, cultural adaptation and validation of the Liverpool Adverse Events Profile (LAEP) into a PortugueseBrazilian version and evaluate its reliability and validity in patients with symptomatic partial (SPE) and idiopathic generalized epilepsies (IGE) (ILAE, 1989). LAEP is a scale to measure patients perception about adverse eff
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/06/2011
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7. Determinação de ácido valpróico em soro por cromatografia líquida de alta eficiência com detector de arranjo de diodos (CLAE-DAD), após derivatização com brometo de fenacila
Valproic acid (VA) is a drug used to control seizures in several epileptic conditions. In VA pharmacotherapy, therapeutic drug monitoring is recommended to obtain adequate seizure control and avoid toxicity. The aim of this study was to validate a method for the determination of valproic acid in serum, employing high performance liquid chromatography with di
Química Nova. Publicado em: 2009
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8. Evaluation of the muscle strength and motor ability in children with spinal muscle atrophy type II and III treated with valproic acid / Avaliação da força muscular e da habilidade motora das crianças com amiotrofia espinhal progressiva do tipo II e III medicadas com ácido valpróico
Spinal Muscular Atrophy (SMA) is an autosomal recessive disorder that affects the spinal motoneurons, resulting in hypotonia and muscle weakness. The knowledge of the molecular mechanism of SMA has originated new researches including clinical trials with pharmacological agents that increase SMN2 protein level. Many drugs with this action are being tested wit
Publicado em: 2009
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9. Estudos para obtenção e caracterização de sistemas nanoparticulados contendo ácido valpróico e avaliação da penetração deste através da barreira hematoencefálica / Obtention and characterization of nanoparticulated systems loaded with valproic acid and evaluation of its blood-brain barrier penetration
A epilepsia é normalmente a associação de pré-disposição genética e doença ou uma lesão cerebral. Aproximadamente 1 entre 50 a 100 pessoas apresentam essa pré-disposição à convulsões. Um dos fármacos mais prescritos e utilizados para o tratamento de convulsões é o ácido valpróico (AV), tornando-se a medicação de primeira escolha no trata
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2009
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10. Análise observacional de aquisições motoras em crianças portadoras de Amiotrofia Espinal Tipo I submetidas à intervenção medicamentosa com ácido valpróico / Observatory analyse of motor gain in type I spinal amyotrophy children with valproic acid use
The spinal muscle atrophy (SMA) is the most frequent neuromuscular disease responsible for Hypotonic Children Syndrome (HCS). SMA is caused by anterior horn cells degeneration in the narrow. The neurological impairment is quickly and strongly established in the first months of life, so, after few months, the only movement that the children can do is moving t
Publicado em: 2008
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11. Desenvolvimento de um modelo animal para autismo induzido pelo valproato: domínio do comportamento de aprendizagem
Estudos experimentais vêm buscando desenvolver modelos de testes comportamentais para roedores na tentativa de avaliar os três domínios que caracterizam o autismo: prejuízos na interação social; na comunicação verbal e não-verbal; padrões de comportamento, interesses, atividade restrita, comportamento repetitivo e estereotipado Um dos modelos basei
Publicado em: 2008
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12. Actual bioavailability of divalproex sodium extended-release tablets and its clinical implications
Divalproex sodium extended-release dosage form (divalproex-ER) has been promoted as innovative formulation for the treatment of epilepsy and manic disorders, and for migraine headache prevention, with the advantage of being dosing once a day. Due to a significant decreasing in the peak-trough fluctuation of plasma valproic acid levels, in comparison with the
Journal of Epilepsy and Clinical Neurophysiology. Publicado em: 2007-06