Tn Antigen
Mostrando 1-12 de 88 artigos, teses e dissertações.
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1. Recombinant 60-kDa heat shock protein from Paracoccidioides brasiliensis: is it a good antigen for serological diagnosis of paracoccidioidomycosis?
Paracoccidioides brasiliensis and P. lutzii are fungi that cause paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in South America. For serological diagnosis, although 43-kDa glycoprotein (gp43) is regarded as highly specific for PCM, the occurrence of false negative reactions in sera from patients infected with P. lutzii suggests that prepa
Braz J Med Biol Res. Publicado em: 03/04/2017
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2. Síntese e avaliação biológica de glicodicetopiperazinas relacionadas a mucinas de células tumorais e parasitárias / Synthesis and biological evaluation of glycodiketopiperazines related to mucins from tumoral and parasite cells
Mucinas são glicoproteínas altamente O-glicosiladas cuja principal característica estrutural é a presença de -GalNAc ligado aos resíduos hidroxilados de serina e treonina. Em alterações celulares malignas, esse núcleo é exposto como um antígeno carboidrato associado a tumor (Tn) e sua alta expressão em células cancerosas faz dele um alvo para o
Publicado em: 2010
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3. DeterminaÃÃo da troponina T cardÃaca humana empregando sistema de microbalanÃa de quartzo por injeÃÃo de fluxo
The cardiac troponin T (cTnT) is important specific biomarker in establishing diagnosis and predicting prognosis in patients with suspected acute myocardial infarctions (AMI). In this work, a flow injection system quartz microbalance based on the alteration of electric frequency in response to the antigen-antibody interaction was used for determination of th
Publicado em: 2007
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4. Amplificação, clonagem e expressão de proteína recombinante do vírus da doença de Aujeszky em sistema de baculovírus para utilização em programa de controle e erradicação / Amplification, cloning and expression of the recombinant protein of the Aujesskys disease vírus in baculovirus system for use in control and eradication program
Aujeszkys disease (AD) is an infect-contagious illness that causes serious economical damages to the producer and the swine industry. Aiming to develop mechanisms and to improve technologies that are faster, more sensitive and more specific for diagnosis and for use in free areas or in ADs eradication programs, the sequence codifier of the glycoprotein E (gE
Publicado em: 2006
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5. Presence of the Tn antigen on hematopoietic progenitors from patients with the Tn syndrome.
The Tn syndrome is an acquired clonal disorder characterized by the exposure of a normally hidden determinant, the Tn antigen, on the surface of human erythrocytes, platelets, granulocytes, and lymphocytes. Two distinct populations, Tn positive (Tn+) and Tn negative (Tn-), of mature hemopoietic cells are present in Tn patients. To determine whether the Tn an
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6. Differential expression of the cancer associated antigens T (Thomsen-Friedenreich) and Tn to the skin in primary and metastatic carcinomas.
AIM: To study the immunohistochemical expression of the Thomsen-Friedenreich antigen (T) and its precursor, Tn, in the skin in various cancers. METHODS: T and Tn antigens were studied with monoclonal antibodies in 91 primary premalignant and malignant lesions, 13 cases of Paget's disease, and 26 carcinomas metastatic to the skin. The material had been collec
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7. Immunocytological analysis of the Tn associated antigen 83D4 in serous effusions from patients with cancer: comparison with Tn soluble glycoprotein.
AIMS--To determine whether the monoclonal antibody (MoAb) 83D4, previously shown to be highly specific for carcinoma cells, can be used as an immunocytological marker to discriminate between benign and malignant cells in serous effusions; and to test for a correlation between expression of the antigen reacting with MoAb 83D4 on effusion cells and the amount
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8. Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus.
The cancer-related mucin-type carbohydrate neoantigen Tn was found on gp160 and gp120 of human immunodeficiency virus (HIV). Immunoglobulin G (IgG) and IgM monoclonal antibodies (MAbs) against Tn neutralized infection with cell-free virus and blocked fusion between HIV-infected and uninfected cells. This inhibition was found in infection of both lymphocytic
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9. Identification and Characterization of Genes Required for Early Myxococcus xanthus Developmental Gene Expression
Starvation and cell density regulate the developmental expression of Myxococcus xanthus gene 4521. Three classes of mutants allow expression of this developmental gene during growth on nutrient agar, such that colonies of strains containing a Tn5 lac Ω4521 fusion are Lac+. One class of these mutants inactivates SasN, a negative regulator of 4521 expression;
American Society for Microbiology.
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10. Intact motility as a Salmonella typhi invasion-related factor.
Invasiveness of Salmonella typhi was investigated. At first, we introduced Tn5 into the chromosome of a wild-type S. typhi strain, GIFU 10007, and screened the independent Tn5 insertion mutants for noninvasive (Inv-) strains. During the first half of this work, we obtained 4 Inv- strains from 1,338 independent Tn5 mutants. The four were either nonflagellate
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11. Cloning and expression of genes encoding pheromone-inducible antigens of Enterococcus (Streptococcus) faecalis.
Fragments, generated by restriction enzyme digestion, of the 58-kilobase Enterococcus (Streptococcus) faecalis tetracycline resistance plasmid pCF10 were cloned and introduced into Escherichia coli and E. faecalis to characterize the pheromone-inducible conjugation system encoded by this plasmid. Western blot (immunoblot) analyses revealed that a 130-kilodal
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12. Enterococcus faecalis aggravates pyelonephritis caused by Pseudomonas aeruginosa in experimental ascending mixed urinary tract infection in mice.
Mixed urinary tract infection was caused by simultaneous inoculation of 10(4) CFU each of Enterococcus faecalis TN2005 and Pseudomonas aeruginosa P9 into the bladders of CBA/J mice. Both organisms proliferated in the kidneys, and viable cell counts of E. faecalis TN2005 reached a peak level of 4.1 x 10(5) CFU per pair of kidneys within the first 24 h, while