Skeletal Muscle Atrophy
Mostrando 1-12 de 71 artigos, teses e dissertações.
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1. Diretrizes Brasileiras de Mobilização Precoce em Unidade de Terapia Intensiva
RESUMO A imobilidade pode causar várias complicações que influenciam na recuperação de doentes críticos, incluindo atrofia e fraqueza muscular esquelética. Esse efeito pode ser amenizado com a realização de mobilização precoce. Seis questões primordiais nortearam essa pesquisa: É segura? Quem é o candidato à mobilização precoce? Quais são a
Rev. bras. ter. intensiva. Publicado em: 20/01/2020
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2. Effects of physical exercise on skeletal muscles of rats with cerebral ischemia
Physical exercise is a known preventive and therapeutic alternative for several cerebrovascular diseases. Therefore, the objective of the present study was to evaluate the motor performance and histomorphometry of the biceps brachii, soleus, and tibialis anterior muscles of rats submitted to a treadmill training program prior to the induction of cerebral isc
Braz J Med Biol Res. Publicado em: 28/11/2019
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3. Short-term creatine supplementation changes protein metabolism signaling in hindlimb suspension
The effect of a short-term creatine supplementation on hindlimb suspension (HS)-induced muscle atrophy was investigated. Creatine monohydrate (5 g/kg b.w. per day) or placebo, divided in 2 daily doses, was given by oral gavage for 5 days. Rats were maintained in HS with dietary supplementation concomitantly for 5 days. Body weight, soleus and EDL muscle mass
Braz J Med Biol Res. Publicado em: 07/10/2019
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4. Elevated serum Activin A in chronic obstructive pulmonary disease with skeletal muscle wasting
OBJECTIVE: Muscle wasting contributes to the reduced quality of life and increased mortality in chronic obstructive pulmonary disease (COPD). Muscle atrophy in mice with cachexia was caused by Activin A binding to ActRIIB. The role of circulating Activin A leading to muscle atrophy in COPD remains elusive. METHODS: In the present study, we evaluated the re
Clinics. Publicado em: 27/06/2019
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5. Fasting: a major limitation for resistance exercise training effects in rodents
Protocols that mimic resistance exercise training (RET) in rodents present several limitations, one of them being the electrical stimulus, which is beyond the physiological context observed in humans. Recently, our group developed a conditioning system device that does not use electric shock to stimulate rats, but includes fasting periods before each RET ses
Braz J Med Biol Res. Publicado em: 17/11/2017
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6. Myostatin promotes distinct responses on protein metabolism of skeletal and cardiac muscle fibers of rodents
Myostatin is a novel negative regulator of skeletal muscle mass. Myostatin expression is also found in heart in a much less extent, but it can be upregulated in pathological conditions, such as heart failure. Myostatin may be involved in inhibiting protein synthesis and/or increasing protein degradation in skeletal and cardiac muscles. Herein, we used cell c
Braz J Med Biol Res. Publicado em: 19/10/2017
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7. Exercise training prevents skeletal muscle damage in an experimental sepsis model
OBJECTIVE: Oxidative stress plays an important role in skeletal muscle damage in sepsis. Aerobic exercise can decrease oxidative stress and enhance antioxidant defenses. Therefore, it was hypothesized that aerobic exercise training before a sepsis stimulus could attenuate skeletal muscle damage by modulating oxidative stress. Thus, the aim of this study was
Clinics. Publicado em: 2013-01
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8. Efeitos do treinamento físico aeróbio em alta intensidade na musculatura esquelética de ratos infartados / Effects of high-intensity aerobic interval training on skeletal muscle of infarcted rats
A miopatia esquelética em doenças sistêmicas é um importante preditor de mortalidade e prognóstico em diversas síndromes, incluindo a insuficiência cardíaca. Os danos músculo-esqueléticos em situações de comprometimento cardíaco são descritos pela literatura há décadas, entretanto, nenhum recurso farmacológico proposto até o momento mostrou
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/02/2012
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9. PPM1B and P-IKKβ expression levels correlated inversely with rat gastrocnemius atrophy after denervation
Activated inhibitor of nuclear factor-κB kinase β (IKKβ) is necessary and sufficient for denervated skeletal muscle atrophy. Although several studies have shown that Mg2+/Mn2+-dependent protein phosphatase 1B (PPM1B) inactivated IKKβ, few studies have investigated the role of PPM1B in denervated skeletal muscle. In this study, we aim to explore the expre
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-08
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10. Skeletal muscle major histocompatibility complex class I and II expression differences in adult and juvenile dermatomyositis
OBJECTIVE: To analyze major histocompatibility complex expression in the muscle fibers of juvenile and adult dermatomyositis. METHOD: In total, 28 untreated adult dermatomyositis patients, 28 juvenile dermatomyositis patients (Bohan and Peter's criteria) and a control group consisting of four dystrophic and five Pompe's disease patients were analyzed. Routin
Clinics. Publicado em: 2012-08
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11. Paradoxical sleep deprivation is related to muscle atrophy and damages muscle recovery / A privação de sono paradoxal em ratos está associada a atrofia muscular e déficit na recuperação muscular
Introduction: Paradoxical sleep deprivation (PSD) in rats is able to induce reductions in body mass and body fat, due to increased secretion of pituitary-adrenal axis hormones. Considering that PSD is also associated with a decrease in anabolic hormones, skeletal muscle can also be strongly influenced, causing atrophy damaging its recovery after a lesion. Ob
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/07/2011
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12. Análise estrutural e ultra-estrutural dos músculos esternomastóideo e cleidomastóideo de ratos wistar adultos e idosos. / Structural and ultrastructural analysis of the sternomastoid and cleidomastoid muscles of the adults and aged Wistar rats.
O objetivo do presente estudo foi analisar estrutural e ultra-estruturalmente os músculos EM e CM adultos e idosos empregando métodos de microscopia de luz, microscopia eletrônica de varredura, microscopia eletrônica de transmissão. Os resultados revelaram os feixes de fibras colágenas que constituem o endomísio, perimísio e epimísio presentes no te
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/03/2011