Riluzole
Mostrando 1-10 de 10 artigos, teses e dissertações.
-
1. The Effects of Riluzole on Cisplatin-induced Ototoxicity
Abstract Introduction Riluzole (2-amino-6-trifluoromethoxy benzothiazole) is known as a neuroprotective, antioxidant, antiapoptotic agent. It may have beneficial effects on neuronal cell death due to cisplatin-induced ototoxicity. Objective To evaluate the effect of riluzole on cisplatin-induced ototoxicity in guinea pigs. Methods Twenty-four guinea pi
Int. Arch. Otorhinolaryngol.. Publicado em: 07/10/2019
-
2. Neuroprotective properties of RT10, a fraction isolated from Parawixia bistriata spider venom, against excitotoxicity injury in neuron-glia cultures
Abstract Background: L-Glutamate (L-Glu), the major excitatory neurotransmitter in the mammalian Central Nervous System (CNS), is essential to cognitive functions. However, when L-Glu is accumulated in large concentrations at the synaptic cleft, it can induce excitotoxicity that results in secondary damage implicated in many neurological disorders. Current
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 16/05/2019
-
3. Impacto de fatores epidemiológicos e clínicos sobre o benefício do riluzol nas taxas de sobrevida de pacientes com ELA
RESUMO Objetivo Investigar o impacto de fatores epidemiológicos e clínicos sobre o benefício do riluzole em pacientes com esclerose lateral amiotrófica (ELA). Métodos A sobrevida de 578 pacientes com ELA (1999-2011) foi analisada por estatística descritiva e curvas de Kaplan-Meier. Considerando a mediana do tempo de sobrevida (19 meses), a amostra
Arq. Neuro-Psiquiatr.. Publicado em: 2017-08
-
4. Avaliação da atividade neuroprotetora da Parawixina 11 isolada da peçonha da aranha Parawixia bistriata (Araneae, Araneidae), em ratos Wistar submetidos a um modelo de glaucoma agudo / Neuroprotective activity analysis of Parawixin 11, isolated from Parawixia bistriata (Araneae, Araneidae) spider venom, in Wistar rats submitted to an model of acute glaucoma
Glaucoma is defined as a typical optic neuropathy characterized by ganglion cells loss and consequent optic nerve damage, resulting in a gradual reduction of the visual field and eventual blindness. In regard to compounds present in spider venoms, they represent an interesting source of bioactive molecules and the study about the possible neuroprotective eff
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/04/2012
-
5. Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin
TsTX is an α-type sodium channel toxin that stimulates the discharge of neurotransmitters from neurons. In the present study we investigated which neurotransmitters are released in the hippocampus after TsTX injection and if they are responsible for electrographic or histopathological effects. Microdialysis revealed that the toxin increased glutamate extrac
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2009
-
6. Esclerose lateral amiotrofica : estudo prospectivo de parametros respiratorios / Amyotrophic lateral sclerosis : prospectivestudy on respiratory parameters
The objective of this study was to evaluate the respiratory function of patients with amyotrophic lateral sclerosis (ALS), using the parameters of spirometry, maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP), arterial blood gases and pulse oximetry, and monitor them during the period of 8 months. The study was crosssectional assessmen
Publicado em: 2009
-
7. Increase of flexor reflex latency in patients with amyotrophic lateral sclerosis treated with riluzole.
-
8. Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay
Preventing the formation of insoluble polyglutamine containing protein aggregates in neurons may represent an attractive therapeutic strategy to ameliorate Huntington's disease (HD). Therefore, the ability to screen for small molecules that suppress the self-assembly of huntingtin would have potential clinical and significant research applications. We have d
The National Academy of Sciences.
-
9. Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia
Cerebellar ataxia, a devastating neurological disease, may be initiated by hyperexcitability of deep cerebellar nuclei (DCN) secondary to loss of inhibitory input from Purkinje neurons that frequently degenerate in this disease. This mechanism predicts that intrinsic DCN hyperexcitability would cause ataxia in the absence of upstream Purkinje degeneration. W
American Society for Clinical Investigation.
-
10. Activation of mGluR5 induces spike afterdepolarization and enhanced excitability in medium spiny neurons of the nucleus accumbens by modulating persistent Na+ currents
The involvement of metabotropic glutamate receptors type 5 (mGluR5) in drug-induced behaviours is well-established but limited information is available on their functional roles in addiction-relevant brain areas like the nucleus accumbens (NAc). This study demonstrates that pharmacological and synaptic activation of mGluR5 increases the spike discharge of me
Blackwell Science Inc.