Esclerose lateral amiotrofica : estudo prospectivo de parametros respiratorios / Amyotrophic lateral sclerosis : prospectivestudy on respiratory parameters

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

The objective of this study was to evaluate the respiratory function of patients with amyotrophic lateral sclerosis (ALS), using the parameters of spirometry, maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP), arterial blood gases and pulse oximetry, and monitor them during the period of 8 months. The study was crosssectional assessment in first evaluation and longitudinal prospective study. Sixteen patients with probable or defined ALS were selected. They were on riluzole and had regular attendance. Exclusion criteria were: associated pulmonary diseases, assisted ventilation, gastrostomy or feeding tube. In the longitudinal study partial arterial carbonic gas pressure (PaCO2) was a significant parameter to follow up disease evolution. In the cross-sectional study there was a significant correlation between: MIP and MEP; body mass index (BMI) and MIP; BMI and MEP; pulse oximetry and forced vital capacity; bicarbonate and PaCO2. There were significant correlations between dyspnea (MDRS scale), quality of life (questionnaire ALSQ 40) and health perception (SF-36 scale). In ALS patients with predominant apendicular onset there were correlations among the spirometry, arterial blood gases and SF36. The lung function in patients with ALS followed over 8 months remained in the normal range, although the sample was heterogeneous with outpatients and wheelchair users. The PaCO2 was shown to be an efficient and significant parameter in the measurement of respiratory impairment

ASSUNTO(S)

amyotrophic lateral sclerosis esclerose amiotrofica lateral testes funcionais dos pulmões respiratory function tests

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