Receptors Serotonin
Mostrando 13-24 de 224 artigos, teses e dissertações.
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13. Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats
Serotonin (5-HT1B) receptors play an essential role in the inhibition of aggressive behavior in rodents. CP-94,253, a 5-HT1B receptor agonist, can reduce aggression in male mice when administered directly into the ventro-orbitofrontal (VO) prefrontal cortex (PFC). The objective of the current study was to assess the effects of two selective 5-HT1B receptor a
Publicado em: 2010
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14. Atividade antinociceptiva e antitumoral de compostos isolados da Pterodon pubescens Benth. (Leguminosae- papilionoidea) / Antinociceptive and antitumor activity of compounds isolated from Pterodon pubescens Benth. (Leguminosae- papilionoidea)
Pterodon pubescens Benth. species is widespread used in folk medicine. In this study, we demonstrated the antinociceptive (analgesic) and anti-tumor activity of compounds isolated from species. The most relevant results were: 1) bioactivityguided fractionation, isolation and identification of compounds using in vitro and in vivo assays; 2) identification of
Publicado em: 2010
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15. Envolvimento dos receptores 5-HT2c do hipocampo ventral na modulação de estados de ansiedade em ratos
The present study investigated the effects of pharmacological blockade of 5-HT2C receptors of the ventral hippocampus (VH) on anxiety levels of rats induced by 5-HT2C agonists. Ten minutes after intraperitoneal (i.p.) injections of either saline (0.9%) or the 5-HT2C agonist WAY-161503 (3mg/kg), rats were bilaterally microinjected in the VH with saline or wit
Publicado em: 2010
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16. Administração do 8-OH-DPAT no septo dorso lateral de camundongos submetidos ao labirinto em cruz elevado promove efeito ansiolítico que é revertido pelo prétratamento local com WAY100635
Research on anxiety often involves the use of animal models for investigation of therapeutic compounds. Thus, the elevated plus maze (EPM) is one of the most commonly model used in research involving anxiety and it has been validated for rats and mice. Serotonin (5-HT) is a neurotransmitter involved not only in anxiety but also in other disorders. Some repor
Publicado em: 2010
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17. Núcleo mediano da rafe e estresse de nado forçado: papel dos receptores de glutamato de tipo NMDA / Median Raphe Nucleus and Forced Swim stress: role of glutamate NMDA receptors
Exposure to uncontrollable stressors leads to behavioral and neurochemical changes, which has been associated to mal functioning of the Median Raphe Nucleus (MnRN)-Dorsal Hippocampus (DH) serotoninergic pathway. These deficits can be attenuated by intra-hippocampal injections of NMDA antagonists or 5-HT1a agonists. Activation of MnRN glutamatergic NMDA recep
Publicado em: 2010
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18. Administração prolongada do ácido 13-cis-retinóico (isotretinoína) em camundongos machos adolescentes: comportamentos emocionais e quantificação de transcritos de componentes do sistema serotoninérgico central. / Chronic administration of 13-cis-retinoic acid (isotretinoin) in young male mice: emotion-related behaviors and quantification of central serotonergic system transcripts.
O ácido 13-cis-retinóico (13-cis-RA, isotretinoína) é um retinóide sintético de uso oral prolongado, prescrito em altas doses, para o tratamento da acne. Age primariamente diminuindo a atividade da glândula sebácea e reduzindo a inflamação. Desde a aprovação do uso do 13-cis-RA, tem-se relatos na literatura de sintomas psiquiátricos incluindo de
Publicado em: 2010
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19. Tratamento neonatal com agonista 5-HT1A: repercussÃes sobre o desenvolvimento da atividade locomotora em ratos
Locomotion is an important function to living beings. Environmental changes that occur during the critical period of development can promote changes in the development of locomotor activity, bringing impairment for the individual. Works using automatic analysis of behavior are of great importance for the study of locomotion. Among the systems that can influe
Publicado em: 2009
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20. Núcleo central da amígdala e Núcleo parabraquial lateral no controle da ingestão de sódio
Previous studies have shown the importance of serotonergic GABAergic and aadrenergic mechanisms of the lateral parabraquial nucleus (LBPN) in the control of sodium intake. The importance of the central nucleus of the amygdala (CeA) for sodium intake induced by different protocols was also demonstrated. Considering the studies showing reciprocal connections b
Publicado em: 2009
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21. Analise histologica do aparato venenifero e caracterização farmaco-bioquimica da peçonha de Vitalius dubius (Araneae, Theraphosidae) / Histological analysis of the venom apparatus and biochemical and pharmacological characterization of venom from Vitalius dubius (Araneae, Theraphosidae)
Vitalius dubius is a medium-sized, non-aggressive tarantula found in southeastern Brazil. In this work, we examined the histological organization of the venom apparatus of V. dubius and investigated some biochemical and pharmacological properties of this spider´s venom. The venom apparatus consisted of two chelicerae fitted with large fangs for prey immobil
Publicado em: 2008
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22. Effect of 5-HT1B receptor agonists injected into the prefrontal cortex on maternal aggression in rats
Serotonin (5-HT1B) receptors play an essential role in the inhibition of aggressive behavior in rodents. CP-94,253, a 5-HT1B receptor agonist, can reduce aggression in male mice when administered directly into the ventro-orbitofrontal (VO) prefrontal cortex (PFC). The objective of the current study was to assess the effects of two selective 5-HT1B receptor a
Brazilian Journal of Medical and Biological Research. Publicado em: 04/05/2007
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23. Aspectos do envelhecimento cerebral e função cognitiva em modelo experimental animal e estudo de mecanismos de neurodegeneração em cultura celular
The two phenomena, biological and behavioural, approached in the present work are brain aging and spatial memory. Several studies, comparative and experimental, have shown that aged subjects present significantly impaired performances in different types of cognitive tasks. It is also known that contradictions in literature exist in relation to consequences o
Publicado em: 2007
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24. Efeitos do tratamento neonatal com inibidor Seletivo da recaptaÃÃo de serotonina sobre a Atividade osteoblÃstica e o crescimento de fÃmures de ratos
The interaction evidences are growing between the nervous system and the bone metabolism. Recent studies evidence glutamatergic, dopaminergic and serotoninergic receptors in the bone cells. However it is not still well documented the paper of the serotonina in the bone. In the present study, we investigated the role of the serotonin on the growth and develop
Publicado em: 2006