Receptors Complement 3b
Mostrando 1-12 de 109 artigos, teses e dissertações.
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1. Fc?R e CR3 no lúpus eritematoso sistêmico: variantes polimórficas e sua influência na fagocitose e desgranulação dos neutrófilos / Fc?R and CR in systemic lupus erythematosus: polimorphisms and their influence in the phagocytosis and degranulation of neutrophils
Systemic lupus erythematosus (SLE) is an autoimmune disease in which disease-related and genetic factors and immunosuppressive and cytotoxic therapies all contribute to an increased susceptibility to infections. Factors predisposing to infection include defects in chemotaxis, abnormalities in neutrophil phagocytic activity, decreased immune complex (IC) and
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/08/2012
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2. Analise por citometria de fluxo da expressão dos receptores FCy e complemento em monocitos de pacientes com agamaglobulinemia ligada ao X e imunodeficiencia comum variavel / Flow cytometry analysis of the expression of FCy and complement receptors in monocytes of X-linked agammaglobulinaemia and common variable immunodeficiency patients
Recentemente, demonstramos defeitos na fagocitose e quimiotaxia de monócitos em pacientes com agamaglobulinemia ligada ao X (ALX) e imunodeficiência comum variável (ICV). Existem poucos dados da expressão in vivo dos receptores para a região constante de imunoglobulina G (IgG) (FcyR) e receptores de complemento (RC) nesses pacientes. O objetivo deste es
Publicado em: 2009
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3. Influence of point variants of pattern recognition receptors in the susceptibility to human malaria / Influência de variantes de receptores de reconhecimento padrão na suscetibilidade à malária
Malaria is one of the major causes of disease and death worldwide, mainly of children. It is also the strongest known force for evolutionary selection in the recent history of the human genome. Besides environmental and parasite factors, host genetic factors play a major role in determining both susceptibility to malaria and the course of infection. Innate i
Publicado em: 2008
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4. The role of complement in the modulation by fluid-phase IgG of the production of reactive oxygen species by polymorphonuclear leukocytes stimulated with IgG immune complexes
The production of reactive oxygen species (ROS) by polymorphonuclear leukocytes (PMN) can be induced by immune complexes and is an important component of phagocytosis in the killing of microorganisms, but can also be involved in inflammatory reactions when immune complexes are deposited in tissues. We have observed that fluid-phase IgG can inhibit the genera
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-12
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5. Interaction of human monocytes, macrophages, and polymorphonuclear leukocytes with zymosan in vitro. Role of type 3 complement receptors and macrophage-derived complement.
Macrophages take up zymosan in the absence of exogenous complement via receptors for iC3b (type 3 complement receptors) acting with or without lectin-like receptors for mannosyl-fucosyl-terminated glycoconjugates. We previously provided evidence that macrophages themselves secrete complement-alternative pathway components able to opsonize zymosan locally (Ez
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6. Phagocytosis of leprosy bacilli is mediated by complement receptors CR1 and CR3 on human monocytes and complement component C3 in serum.
Mycobacterium leprae, an obligate intracellular pathogen, invades and multiplies within host mononuclear phagocytes. To understand M. leprae invasion better, we have investigated the role of phagocyte receptors and bacterium-bound ligands in phagocytosis of M. leprae by human monocytes. Complement receptors CR1 and CR3 mediate adherence and phagocytosis of M
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7. Leishmania major-human macrophage interactions: cooperation between Mac-1 (CD11b/CD18) and complement receptor type 1 (CD35) in promastigote adhesion.
It has been suggested that the developmental maturation of Leishmania major promastigotes can affect their interaction with human complement receptors. To study this, we measured the adhesion of metacyclic and logarithmic-phase L. major promastigotes to complement receptors expressed on primary macrophages, to recombinant receptors expressed on transfected c
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8. The role of complement component C3b and its receptors in sperm-oocyte interaction.
Previous studies have shown that human sperm that have undergone the acrosome reaction express a unique tissue-specific variant of the complement component 3 (C3)-binding molecule membrane cofactor protein (MCP, CD46) and that damaged or dead sperm activate the alternative pathway of complement and bind C3 catabolites. In this study we provide evidence that
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9. Capsular polysaccharide regulates neutrophil complement receptor interactions with type III group B streptococci.
The capsular polysaccharide of type III group B streptococci contributes substantially to the virulence of this organism. We explored the extent to which capsular polysaccharide influences neutrophil complement receptor interactions by using a poorly encapsulated strain (COH 31r/s), two well-encapsulated strains (M732 and M912), and strains produced from COH
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10. Complement-dependent cellular cytotoxicity: lymphoblastoid lines that activate complement component 3 (C3) and express C3 receptors have increased sensitivity to lymphocyte-mediated lysis in the presence of fresh human serum.
Lymphocyte-mediated lysis of cells of the Raji, Daudi, Jijoye, and Bjab lines was elevated when fresh human serum was added to the assay. A higher proportion of effector-target conjugates was observed in the presence of human serum. In similar experiments lysis of 1301, Rael, and P3HR-1 cells was unaltered. All cell lines activated the alternative pathway of
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11. Binding of Cryptococcus neoformans to heterologously expressed human complement receptors.
Previously, we demonstrated that monoclonal antibodies (MAb) directed against any of the three defined complement receptors (CR) for the third component of complement (CR1, CR3, and CR4) profoundly inhibited the binding of serum-opsonized Cryptococcus neoformans to monocyte-derived macrophages. These studies suggested either that a synergistic interaction be
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12. Roles of macrophage Fc and C3b receptors in phagocytosis of immunologically coated Cryptococcus neoformans.
I have studied the roles of macrophage Fc and C3b receptors in the cell's interaction with encapsulated Cryptococcus neoformans and have defined the effects of a lymphokine that enhances macrophage complement receptor function, the effects of ingestion of soluble immune complexes, and the effects of corticosteroid treatment upon the ability of macrophages to