Prototypes
Mostrando 25-36 de 322 artigos, teses e dissertações.
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25. Study on Experimental Leishmanicidal Activity and in silico of Cytochalasin B
Leishmaniasis is a neglected infectious disease caused by different species of the Leishmania parasite and is one of the major public health problems in developing countries. Despite the progress in fundamental knowledge about the Leishmania parasite, current therapy against leishmaniasis is still unsatisfactory due to limited efficacy, prolonged treatment,
J. Braz. Chem. Soc.. Publicado em: 2019-03
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26. A New Phe-Free Protein Substitute Engineered to Allow a Physiological Absorption of Free Amino Acids for Phenylketonuria
Abstract An innovative technology (Physiomimic Technology) has been applied to amino acids (AAs) formulated for patients with phenylketonuria, with the objective of masking AA taste and odor and prolonging AA release in the gut, allowing a physiological absorption. This technology entails that the AAs are processed with functional additives that are able to
J. inborn errors metab. screen.. Publicado em: 28/02/2019
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27. Lupeol and its esters: NMR, powder XRD data and in vitro evaluation of cancer cell growth
ABSTRACT The triterpene lupeol (1) and some of its esters are secondary metabolites produced by species of Celastraceae family, which have being associated with cytotoxic activity. We report herein the isolation of 1, the semi-synthesis of eight lupeol esters and the evaluation of their in vitro activity against nine strains of cancer cells. The reaction of
Braz. J. Pharm. Sci.. Publicado em: 01/02/2018
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28. SIMILITUDE AND THERMAL PERFORMANCE ON NON-CONVENTIONAL ROOFS
ABSTRACT The objectives of this study were to evaluate the thermal comfort and the similitude between prototypes and reduced models, using non-conventional coverage with green roof and expanded clay aggregate, supported on wood frame structure. For this, were determined the Black Globe Temperature and Humidity Index (BGHI), the Human Discomfort Index (HDI),
Eng. Agríc.. Publicado em: 2018-01
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29. BIOGAS PRODUCTION FROM DAIRY CATTLE MANURE, UNDER ORGANIC AND CONVENTIONAL PRODUCTION SYSTEMS
ABSTRACT The purpose of this study was to evaluate the production of biogas, as well as the biogas production potential resulting from the anaerobic biodigestion of dairy cattle manure under organic (CMOS) and conventional (CMCS) production system. Also, the concentration of thermotolerant coliforms was evaluated after the biodigestion process. Therefore, be
Eng. Agríc.. Publicado em: 2017-12
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30. How 3D printing technologies can contribute into an iterative design process? Case study to hit a drum for Disabled Children
Abstract In the Assistive Technology area and design for disability, users must be taken into account during the design process. Multidisciplinary design team is constituted and an adapted design methodology used. In this design case study, this team has to develop an electromechanical drumstick dedicated to percussion instruments. Objective is to allow Disa
Prod.. Publicado em: 26/10/2017
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31. Impact Analysis of PM magnetization level on motor performance: simulations and experimental results
Abstract This paper addresses the impact of magnetization level tolerances in ferrite-based permanent magnets (PM) on the performance of brushless DC motors. A case study is prepared using three motor prototypes assembled with controlled samples of ferrite arc segments, in terms of magnetization. The investigation is performed both experimentally and through
J. Microw. Optoelectron. Electromagn. Appl.. Publicado em: 2017-03
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32. The Magnetic Tracker with Improved Properties for the Helmet-Mounted Cueing System
ABSTRACT This article highlights both theoretical and experimental experiences in the field of helmet-mounted cueing systems. The current state of these systems is described as optical and hybrid. The adventures of the positioning under local magnetic field are considered, and the directions for further improvement of magnetic technology are identified. A ne
J. Aerosp. Technol. Manag.. Publicado em: 2016-12
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33. Heat pump for thermal power production in dairy farm
ABSTRACT Besides cold for milk cooling, dairy facilities need to produce hot water for cleaning of tools and equipment. Overall, ohmic heating has been used in dairy farms, increasing power consumption and manufacturing costs. Therefore, as an alternative to reduce power consumption, this paper proposed a water-water heat pumping for simultaneous cold and he
Eng. Agríc.. Publicado em: 2016-10
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34. Preparation of Derivatives of Betulinic Acid, Steviol and Isosteviol and Evaluation of Antitrypanosomal and Antimalarial Activities
Derivatives of steviol, isosteviol and betulinic acid were prepared and tested in vitro against Plasmodium falciparum W2 (chloroquine-resistant) and Trypanosoma cruzi. The best results against P. falciparum were found for the betulinic acid derivatives 3-[(2,4-dinitrophenyl)hydrazono]lup-20(29)-en-28-oic acid and 3-hydroxy-20-[(2,4-dinitrophenyl)hydrazono]-2
J. Braz. Chem. Soc.. Publicado em: 2016-06
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35. Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites
This work reports the in vitro activity against Plasmodium falciparumblood forms (W2 clone, chloroquine-resistant) of tamoxifen-based compounds and their ferrocenyl (ferrocifens) and ruthenocenyl (ruthenocifens) derivatives, as well as their cytotoxicity against HepG2 human hepatoma cells. Surprisingly with these series, results indicate that the biological
Mem. Inst. Oswaldo Cruz. Publicado em: 24/11/2015
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36. DESENVOLVIMENTO DE FÁRMACOS POR HIBRIDAÇÃO MOLECULAR: UMA AULA PRÁTICA DE QUÍMICA MEDICINAL USANDO COMPRIMIDOS DE PARACETAMOL E SULFADIAZINA E A FERRAMENTA VIRTUAL
SciFinder ®Medicinal Chemistry is a multidisciplinary discipline and the discovery of new bioactive molecules is one of its objectives. Molecular Hybridization (MH) is a strategy of rational design of new prototypes, where the lead compound is produced through an adequate fusion of pharmacophoric sub-unities. Undergraduate laboratory experiments for Medicinal Chemis
Quím. Nova. Publicado em: 2015-07