Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites

AUTOR(ES)

Souza, Nicolli Bellotti de, Aguiar, Anna Caroline Campos, Oliveira, Alane Cabral de, Top, Siden, Pigeon, Pascal, Jaouen, Gérard, Goulart, Marilia Oliveira Fonseca, Krettli, Antoniana Ursine

FONTE

Mem. Inst. Oswaldo Cruz

DATA DE PUBLICAÇÃO

24/11/2015

RESUMO

This work reports the in vitro activity against Plasmodium falciparumblood forms (W2 clone, chloroquine-resistant) of tamoxifen-based compounds and their ferrocenyl (ferrocifens) and ruthenocenyl (ruthenocifens) derivatives, as well as their cytotoxicity against HepG2 human hepatoma cells. Surprisingly with these series, results indicate that the biological activity of ruthenocifens is better than that of ferrocifens and other tamoxifen-like compounds. The synthesis of a new metal-based compound is also described. It was shown, for the first time, that ruthenocifens are good antiplasmodial prototypes. Further studies will be conducted aiming at a better understanding of their mechanism of action and at obtaining new compounds with better therapeutic profile.

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