Primaquine
Mostrando 1-12 de 74 artigos, teses e dissertações.
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1. Molecular genotyping of G6PD mutations and Duffy blood group in Afro-descendant communities from Brazilian Amazon
Abstract Glucose-6-phosphate dehydrogenase deficiency (G6PDd) and Duffy-negative blood group are two red blood cells variants that confer protection against malaria. In this study, the distribution of the most common G6PD variants (G6PD*A-, GGPD*A and G6PD Mediterranean) and the major alleles of the Duffy blood group (FY*A, FY*B and FY*BES) were investigated
Genet. Mol. Biol.. Publicado em: 29/11/2018
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2. Levels of primaquine and carboxyprimaquine in patients with malaria vivax from the Brazilian Amazon basin
ABSTRACT In the last two years, a substantial increase in the number of malaria vivax cases has occurred in the Brazilian Amazon basin. The adequate exposure of hypnozoites to primaquine is a matter of interest as these dormant forms are responsible for the maintenance or even the increase of malaria burden in endemic areas. The aim of this study was to esti
Rev. Inst. Med. trop. S. Paulo. Publicado em: 25/10/2018
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3. A newly validated high-performance liquid chromatography method with diode array ultraviolet detection for analysis of the antimalarial drug primaquine in the blood plasma
Abstract INTRODUCTION: Primaquine (PQ) diphosphate is an 8-aminoquinoline antimalarial drug with unique therapeutic properties. It is the only drug that prevents relapses of Plasmodium vivax or Plasmodium ovale infections. In this study, a fast, sensitive, cost-effective, and robust method for the extraction and high-performance liquid chromatography with
Rev. Soc. Bras. Med. Trop.. Publicado em: 2017-08
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4. Ultrastructural alterations in Schistosoma mansoni juvenile and adult male worms after in vitro incubation with primaquine
BACKGROUND Praziquantel has been cited as the only drug for treating schistosomiasis. However, concerns over drug resistance have encouraged the search for novel drug leads. The antimalarial drug primaquine possesses interesting anti-schistosmal properties. OBJECTIVES This study is the first to document the potential role of primaquine as a schistosomici
Mem. Inst. Oswaldo Cruz. Publicado em: 02/03/2017
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5. Validation of the rapid test Carestart(tm) G6PD among malaria vivax-infected subjects in the Brazilian Amazon
Abstract: INTRODUCTION: In the Brazilian Amazon, malaria infections are primarily caused by Plasmodium vivax. The only drug that kills the hypnozoite form of P. vivax is primaquine, thereby preventing relapse. However, treating glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals with primaquine can lead to severe hemolysis. G6PD deficiency (G6PDd
Rev. Soc. Bras. Med. Trop.. Publicado em: 2016-08
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6. Effects of primaquine and chloroquine on oxidative stress parameters in rats
A primaquina e cloroquina são utilizadas para o tratamento da malária; evidências da literatura sugerem que estes fármacos podem induzir o estresse oxidativo. Neste estudo investigou-se os efeitos da primaquina e cloroquina sobre danos oxidativo e ao DNA no cérebro, fígado e rim de ratos após 7, 14 e 21 dias de administração. Nossos resultados demon
An. Acad. Bras. Ciênc.. Publicado em: 25/08/2015
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7. Primaquina y recurrencias de malaria por Plasmodium vivax. Metanálisis de estudios clínicos controlados
BACKGROUND: Primaquine (PQ) is used against relapses of vivax malaria (RVM) but several aspects about dosage are unknown, as the total effective dose (TD) in a number of days. OBJECTIVE: To compare PQ regimens against RVM in randomized or non randomized controlled clinical trials (CCTs). METHODOLOGY: Meta analysis. Information was sought until 31 Decem
Rev. bras. epidemiol.. Publicado em: 2015-03
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8. G6PD deficiency in Latin America: systematic review on prevalence and variants
Plasmodium vivax radical cure requires the use of primaquine (PQ), a drug that induces haemolysis in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals, which further hampers malaria control efforts. The aim of this work was to study the G6PDd prevalence and variants in Latin America (LA) and the Caribbean region. A systematic search of the pub
Mem. Inst. Oswaldo Cruz. Publicado em: 19/08/2014
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9. Development and validation of a dissolution test for primaquine/polyethylene oxide matrix tablets
A simple, precise, specific, repeatable and discriminating dissolution test for primaquine (PQ) matrix tablets was developed and validated according to ICH and FDA guidelines. Two UV assaying methods were validated for determination of PQ released in 0.1 M hydrochloric acid and water media. Both methods were linear (R²>0.999), precise (R.S.D.<1.87%) and acc
Quím. Nova. Publicado em: 2013
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10. Recurrencias de malaria por Plasmodium vivax según el uso de primaquina: análisis de estudios descriptivos longitudinales
BACKGROUND: primaquine (PQ) is the only drug available in the market to prevent Plasmodium vivax malaria recurrence, but several aspects are still unknown. OBJECTIVE: To compare PQ regimens to prevent recurrence of vivax malaria. METHODS: systematic review and meta-analysis of data. RESULTS: 1. According to descriptive studies, is PQ effective in preventing
Rev. bras. epidemiol.. Publicado em: 2012-09
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11. Clinical aspects of hemolysis in patients with P. vivax malaria treated with primaquine, in the Brazilian Amazon
This report describes the development of hemolysis in eighteen glucose-6-phosphate dehydrogenase deficient patients treated for Plasmodium vivax malaria with chloroquine and primaquine. The most frequent findings accompanying hemolysis were fever and leukocytosis, in addition to anemia requiring red blood cell transfusion, and development of acute renal fail
Brazilian Journal of Infectious Diseases. Publicado em: 2010-08
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12. Eletrophoretic and spectrometric characterization of Cinchona extracts of use phytoterapic and cosmetic / Caracterização eletroforética e espectrométrica de extratos de Cinchona de uso fitoterápico e cosmético
Every year, malaria kills about one million people. According to OMS, 3.3 billion people, half of the world population, are exposed to the disease, mostly in underdeveloped countries. The pharmaceuticals used in the treatment of malaria include: chloroquine, primaquine, quinine, mefloquine, doxyclyne, clindamicina and artemisin. The increased resistance of t
Publicado em: 2010