Primaquine
Mostrando 13-24 de 74 artigos, teses e dissertações.
-
13. Optimization of controlled release primaquine diphosphate tablets / Otimização da liberação de difosfato de primaquina em comprimidos de liberação controlada
The objective of the present work was to produce primaquine diphosphate controlled release tablets based on hydrophilic polymers and use the mixture statistical experimental design (DOE) to optimize drug release. In selecting the components of the formulations, differential scanning calorimetry (DSC) were carried out to verify the compatibility between drug/
Publicado em: 2009
-
14. Interactions of Anti-malaria Drugs with Model Membranes / Interações de fármacos anti-malária com modelos de membrana
Primaquina e cloroquina são agentes antimaláricos amplamente utilizados profilática e terapeuticamente contra esta enfermidade. A interação destes fármacos com sistemas modelo podem fornecer informações úteis no entendimento dos mecanismos envolvidos em sistemas biológicos reais. Neste sentido, através das técnicas de calorimetria diferencial de
Publicado em: 2009
-
15. Deficiencia de glucosa 6-fostato deshidrogenasa en hombres sanos y en pacientes maláricos; Turbo (Antioquia, Colombia)
INTRODUCTION: Glucose-6-phosphate dehydrogenase (G6PD) deficiency in Latin America has not been fully studied and in Colombia only three outdated publications are known. Recent information on the prevalence of G6PD deficiency is required now, because the recommended treatment of vivax malaria requires higher daily or total doses of primaquine. OBJECTIVE: To
Revista Brasileira de Epidemiologia. Publicado em: 2008-06
-
16. Malaria during pregnancy in a reference centre from the Brazilian Amazon: unexpected increase in the frequency of Plasmodium falciparum infections
Malaria remains globally the most important parasitic disease of man. Data on its deleterious effects during pregnancy have been extensively documented in hyperendemic, holoendemic, and mesoendemic areas from Africa and Asia where Plasmodium falciparum is responsible for almost all infections. However, knowledge about malaria during pregnancy in areas where
Memórias do Instituto Oswaldo Cruz. Publicado em: 2004-02
-
17. DESENVOLVIMENTO E COMPARAÇÃO DE MÉTODOS VOLTAMÉTRICOS PARA A DETERMINAÇÃO DE CICLOFENIL E PRIMAQUINA EM MEDICAMENTOS E EM URINA / DEVELOPMENT AND COMPARISON OF VOLTAMMETRIC METHODS FOR THE DETERMINATION OF CYCLOFENIL AND PRIMAQUINE IN PHARMACEUTICAL FORMULATIONS AND IN URINE
Neste trabalho foram desenvolvidas metodologias eletroanalíticas baseadas na voltametria adsortiva de redissolução catódica com varredura de potencial de onda quadrada e de pulso diferencial para a determinação do ciclofenil em urina e em formulações farmacêuticas, e na voltametria anódica com varredura de potencial de onda quadrada e de pulso dife
Publicado em: 2004
-
18. Correlation between Plasmodium vivax variants in Belém, Pará State, Brazil and symptoms and clearance of parasitaemia
The aim of this study was to determine how different types of P. vivax affect clinical symptoms and parasitaemia clearance. Blood was collected from individuals from Pará State, Brazil. The patients were treated as chloroquine plus primaquine. P. vivax were typed daily till D7 and again on D30. Now we can confirm a previously reported correlation between P.
Brazilian Journal of Infectious Diseases. Publicado em: 2003-06
-
19. Effect of Antimalarial Drugs on Plasmodia Cell-Free Protein Synthesis
A cell-free system from Plasmodium falciparum able to translate endogenous mRNA was used to determine the effect of artemisinin, chloroquine and primaquine on the protein synthesis mechanism of the parasite. The antimalarial drugs did not inhibit the incorporation of [³H] methionine into parasite proteins even at concentrations higher than the ones found to
Memórias do Instituto Oswaldo Cruz. Publicado em: 2002-04
-
20. Comparison of the Curative Antimalarial Activities and Toxicities of Primaquine and Its d and l Isomers
This investigation was undertaken to determine whether either d-primaquine or l-primaquine has sufficient advantage over primaquine to warrant evaluation for curative activity in human volunteers infected with Plasmodium vivax. It was found: (i) that the capacities of the isomers and the racemate to cure infections with Plasmodium cynomolgi in rhesus monkeys
-
21. Activity of clindamycin with primaquine against Pneumocystis carinii in vitro and in vivo.
The combination of primaquine with clindamycin is effective in both in vitro and in vivo models of Pneumocystis infection. Primaquine alone at concentrations from 10 to 300 micrograms/ml reduced the numbers of organisms in cultures to less than 7% of control. Significant inhibition was observed down to 0.1 microgram/ml. Clindamycin at 5 micrograms/ml was ine
-
22. Activities of Artesunate and Primaquine against Asexual- and Sexual-Stage Parasites in Falciparum Malaria
The activities of primaquine in combination with quinine or artesunate against asexual- and sexual-stage parasites were assessed in 176 adult Thai patients with uncomplicated Plasmodium falciparum malaria. Patients were randomized to one of the six following 7-day oral treatment regimens: (i) quinine alone, (ii) quinine with tetracycline, (iii) quinine with
American Society for Microbiology.
-
23. Primaquine Diphosphate: Inhibition of Newcastle Disease Virus Replication
The response of Newcastle disease virus replication to primaquine, an antimalarial drug, was examined in chicken embryo cells (CEC). Virus-induced hemadsorption was completely inhibited by 250 μg of primaquine per ml. At lower concentrations, hemadsorption inhibition was dose dependent. Primaquine retarded virus-induced redistribution of receptor sites on t
-
24. Primaquine: metabolism by microorganisms and 13C nuclear magnetic resonance assignments.
Primaquine (I), a 6-methoxy-8-aminoquinoline derivatives used for the treatment of malaria, has been subjected to metabolic studies using microorganisms. A total of 77 microorganisms (fungi and Streptomyces spp.) were evaluated for their ability to metabolize primaquine. Of these, 23 were found to convert primaquine to one or more metabolites (thin-layer chr