Poly L Lactic Acid
Mostrando 13-24 de 60 artigos, teses e dissertações.
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13. Biological Evaluation of PLDLA Polymer Synthesized as Construct on Bone Tissue Engineering Application
In bone tissue engineering, cell-scaffold constructs are used to stimulate complete, functional tissue replacement that does not occur naturally in critical-size defects. In this report, we describe the application potential of poly (L-co-D,L lactic acid)-PLDLA 70/30, synthesized in house as constructs loaded with osteoblast-like cells on bone tissue enginee
Mat. Res.. Publicado em: 23/02/2016
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14. CARACTERIZAÇÃO E AVALIAÇÃO IN VITRO DE NANOCOMPÓSITOS DE POLI (L-ÁCIDO LÁTICO) E NANOTUBOS DE CARBONO DE PAREDES MÚLTIPLAS PURIFICADOS
Carbon nanotubes (CNT) have been studied for biomedical applications due to their unique properties. However, pristine CNT have structural features and impurities that can cause toxicity to biological systems. In this work, we describe a method to purify multiwalled carbon nanotubes (MWCNT) by chemical modification and subsequent attachment of hydroxyl and c
Quím. Nova. Publicado em: 2015-11
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15. Biodegradable Copolymers Obtained by Solution Polymerization
This study aims the synthesis of copolymers of poly (l-lactic acid) and polycaprolactone by ring opening polymerization. The reactions between l-lactide (LLA) and ε-caprolactone (CL) monomers, in 100/0, 95/5, 90/10 and 80/20 LLA/CL mass ratios, were conducted in refluxing toluene, using Stannous octoate as iniciator, methanol as co-iniciator and inert atmos
Mat. Res.. Publicado em: 23/10/2015
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16. HPLC-DAD and UV-Vis Spectrophotometric Methods for Methotrexate Assay in Different Biodegradable Microparticles
The challenge of the present work concerned the development and validation of high performance liquid chromatography (HPLC) and UV-Vis spectrophotometric methods for quantitation of methotrexate (MTX) loaded on biodegradable microparticles, composed of copolymers with different solubilities such as chitosan and poly (lactic-co-glycolic acid) (PLGA). The line
J. Braz. Chem. Soc.. Publicado em: 2015-04
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17. Influence of Poly-L-Lactic Acid Scaffold's Pore Size on the Proliferation and Differentiation of Dental Pulp Stem Cells
O objetivo desse estudo foi avaliar a influência do tamanho dos poros de um scaffold à base de poli ácido láctico (PLLA) sobre a proliferação e diferenciação de células tronco da polpa dental (dental pulp stem cells - DPSC). Os scaffolds foram preparados dentro da câmara pulpar de discos de terceiros molares (1 mm), utilizando sal como porógeno (1
Braz. Dent. J.. Publicado em: 2015-04
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18. Surface characterization and osteoblast-like Cells culture on collagen modified PLDLA scaffolds
Surface modification techniques based on the grafting of chemical functional groups and immobilization of bioactive molecules have been used to improve biocompatibility and clinical performance of bioabsorbable scaffolds in tissue engineering and medicine regenerative applications. This study aimed at developing and characterizing a biomimetic surface to sti
Mat. Res.. Publicado em: 2014-12
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19. HPLC-FLD method for itraconazole quantification in poly lactic-co-glycolic acid nanoparticles, plasma and tissue
Itraconazol, um antifúngico de amplo espectro, possui muitos efeitos colaterais e o uso de nanossistemas para a entrega de fármacos tem sido proposto como um método para otimizar a farmacocinética da droga e reduzir os efeitos colaterais. Um procedimento de cromatografia líquida de alta performance (HPLC) utilizando detecção fluorimétrica foi desenvo
J. Braz. Chem. Soc.. Publicado em: 2014-04
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20. Preparation and characterization of paclitaxel-loaded PLDLA microspheres
Paclitaxel (Taxol®), is a drug used to treat ovarian, breast, lung and bladder cancer. However, the low solubility of this drug in water is a major limitation in its clinical use. One strategy to overcome this limitation would be to encapsulate paclitaxel in polymeric microspheres that are biocompatible and can be used as drug carriers. The aim of this stud
Mat. Res.. Publicado em: 18/03/2014
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21. In vitro degradation of poly (L-co-D,L lactic acid) containing PCL-T
The application of polymer-based bioresorbable temporary devices in the medical field grows continuously, and professionals from several areas act to solve problems related to body functions lost due to diseases, accidents or natural wear. Here we study the influence from poly(caprolactonetriol) (PCL-T) on the degeneration process in the copolymer poly(L-co-
Polímeros. Publicado em: 2014
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22. In vitro degradation of Poly-L-co-D, L-lactic acid membranes
Poly-L-co-D.L-lactic (PLDLA) is a bioresorbable polymer whose properties have been studied for degradation sensitivity and its application in medicine. In this study, the potential of PLDLA membranes for temporary implantation was evaluated. PLDLA membranes were prepared with the solvent evaporation technique and characterized by differential scanning calori
Mat. Res.. Publicado em: 13/11/2012
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23. Characterization of poly (L-co-D,L Lactic Acid) and a study of polymer-tissue interaction in subcutaneous implants in wistar rats
Poly (L-co-D,L lactic acid) (PLDLA) is an important biomaterial because of its biocompatibility properties that promote cellular regeneration and growth. The aim of this study was to evaluate the polymer-tissue interaction of PLDLA implants in the dorsal subcutaneous tissue of male Wistar rats at various intervals (2, 7, 15, 30, 60 and 90 days) after implant
Mat. Res.. Publicado em: 26/10/2012
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24. The use of vancomycin-loaded poly-l-lactic acid and poly-ethylene oxide microspheres for bone repair: an in vivo study
OBJECTIVE: The aim of this study was to investigate bone repair after the implantation of vancomycin-loaded poly-L-lactic acid/poly-ethylene oxide microspheres compared with vancomycin-unloaded poly-L-lactic acid/poly-ethylene oxide microspheres. METHODS: Poly-L-lactic acid/poly-ethylene oxide microspheres were implanted in rat tibiae and evaluated for perio
Clinics. Publicado em: 2012-07