Phenobarbital
Mostrando 13-24 de 169 artigos, teses e dissertações.
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13. Avaliação farmacológica de extratos e sustâncias obtidas de Plinia glomerata (berg.) / Pharmacological studies of extracts and compounds from Plinia glomerata (Berg.)
Plinia glomerata Berg. (Myrtaceae) is popularly known as cabeludinha. The plant has several synonyms, including Myrciaria glomerata Berg., Eugenia cabelluda Kiaersk, and Eugenia tomentosa Berg. In a bibliographical review of synonyms of the plant, no pharmacological and/or phytochemical studies were found. The plant cabeludinha is acknowledged for its therap
Publicado em: 2008
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14. Metalloporphyrins and salen complexes as a P450 biomimetic model for the metabolism of antiepileptic and antidepressant drugs / Metaloporfirinas e compostos salen como modelos biomiméticos do citocromo P450 no metabolismo de fármacos anticonvulsivante e antidepressivo
In this work, the catalytic activities of metalloporphyrins and the salen complex (Jacobsen catalyst) in solution and immobilized on different supports were studied in the oxidation of hydrocarbons, anticonvulsivant drugs (carbamazepine and primidone) and antidepressives (fluoxetine) by the following oxygen donors: hydrogen peroxide, terc-butyl hydroperoxide
Publicado em: 2008
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15. Efeitos neuromusculares do atracurio e do rocuronio em ratos pre-tratados com carbamazepina e fenobarbital : estudo in vitro e in vivo / Neuromuscular effects of atracurium and rocuronium in pre treated rats with carbamazepine and phenobarbital : study in vitro e in vivo
Atracurium (ATC) and rocuronium (ROC) are neuromuscular blockers of intermediate action. In this study, the neuromuscular effects had been investigated in vitro and in vivo in treated rats, by gavage (7d), with the anticonvulsantes (AC) carbamazepine (CBZ, 40 mg/kg) and phenobarbital (FB, 20 mg/kg) and sacrificed on the eight day, under anesthesia with ureth
Publicado em: 2007
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16. Malformações fetais, defeitos de desenvolvimento e sinais dismorficos em filhos de mães com epilepsia / Fetal malformations, development defects and dysmorphic signs in outcomes of women with epilepsy
Rationale: The majority of women with epilepsy do not experience significant changes during pregnancy; however the persistence of seizures and the effect of antiepileptic drugs (AED) may affect the fetus. These effects include lower intrauterine growth, dysmorphisms, fetal malformation and neuropsicomotor developmental delay. Most studies report that the ris
Publicado em: 2007
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17. Evaluation of the mutagenic potential and in vitro metabolization of three anti-inflammatory parsalmide analogues / Avaliação do potencial mutagenico e metabolização in vitro de tres analogos do antiinflamatorio parsalmide
In this study, the mutagenicity of the anti-inflammatory parsaJmide [5-amino-N-butyl-2-(2-propynyloxy)-benzamide] analogues PA7 [5-anuno-N-butyl-2-cyclohexyloxy-benzamide], PA10 [5-amino-N-butyl-2-phenoxy-benzamide] and PA31 [5-arnino-N-butyl-2-(p-tolyloxy)-benzamide] was determined by an Ames Salmonella assay. The experiments were performed by preincubating
Publicado em: 2006
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18. Alterações morfologicas e atividades e expressão de citocromos P450 no figado de ratos tratados com L-NAME / Hepatic morphological alterations and cytochrome P450 activities and expression in rats treated with L-NAME
Nitric oxide (NO), a co-product of the metabolism of L-arginine to L-citrulline by NO synthases (NOS), has an important role in regulating vascular tone, inflammatory responses, and the gene expression and enzymatic activity of various proteins, including cytochrome P450 and NOS. The chronic inhibition of NOS by Nffi-nitro-L-arginine methyl ester (L-NAME) pr
Publicado em: 2006
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19. Avaliação epidemiológica de doentes mentais em casas de acolhimento de idosos na região sudoeste mineiro-Brasil / Epidemiological evaluation of mentally ill persons residing in Elderly Homes in the Southwest of Minas Gerais State, Brazil
Aims The authors tried to identify de-hospitalized mentally ill patients living in shelters or homes and then quantify and stratify them as to their destinations residence and behavior specially towards other residents in Elderly Homes The de-hospitalizations took place by the end of the 80s with changes to the Mental Health policy the creation of Paulo Delg
Publicado em: 2006
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20. Urolithiasis associated with topiramate
OBJECTIVE: Topiramate is a sulfamate-substituted monosaccharide anticonvulsant used as adjunctive therapy for intractable refractory seizures. It is report a case of topiramate-induced urolithiasis. CASE REPORT: A 35-year-old man presented with acute, right-sided, colicky flank pain. He denied hematuria or dysuria. He was in use of phenytoin, risperidone, ph
International braz j urol. Publicado em: 2004-02
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21. Effect of phenobarbital on inducing insecticide tolerance and esterase changes in Aedes aegypti (Diptera: Culicidae)
The effect of phenobarbital (PB) on the induction of tolerance to the organophosphorous insecticide temephos (TE) was investigated in Aedes aegypti L4 larvae submitted to two different PB-treatments:(1) continuous treatment from the egg to the larval L4 stage and (2) discontinuous treatment in which L4 larvae were exposed for 30 h. Mosquitoes from two Brazil
Genetics and Molecular Biology. Publicado em: 2004
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22. Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors
The aim of the present study was to determine if phenobarbital affects the nociception threshold. Systemic (1-20 mg/kg) phenobarbital administration dose dependently induced hyperalgesia in the tail-flick, hot-plate and formalin tests in rats and in the abdominal constriction test in mice. Formalin and abdominal constriction tests were the most sensitive pro
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-03
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23. Estudo da migração de neutrofilos in vitro em coelhos hepatopatas
The aim of this study was to investigate neutrophil chemotaxis during the induction of liver cirrhosis in rabbits. The study had three expérimentai arms: Group A (n=16) served as controls and received only normal rabbit chow. All animals were sacrificed at 16 weeks. Group B (n=19) was sacrificed 48 h after the chemotaxis assay, which was performed 24 h afte
Publicado em: 2001
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24. Stimulation of hepatic sodium and potassium-activated adenosine triphosphatase activity by phenobarbital. Its possible role in regulation of bile flow.
Since phenobarbital administration produces a profound increase in bile flow without changing bile acid secretion, we examined whether this drug increases the activity of hepatic sodium-potassium-activated ATPase [Na+-K+)-ATPase], the postulated regulating enzyme in the secretion of bile salt independent bile flow. After freeze-thawing to increase substrate