Oral Carcinogenesis
Mostrando 25-36 de 38 artigos, teses e dissertações.
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25. AVALIAÇÃO IN VITRO DA LIBERAÇÃO DE ÍONS E DAS ALTERAÇÕES DE SUPERFÍCIE DE MINI-IMPLANTES ORTODÔNTICOS / AVALIAÇÃO IN VITRO DA LIBERAÇÃO DE ÍONS E DAS ALTERAÇÕES DE SUPERFÍCIE DE MINI-IMPLANTES ORTODÔNTICOS
Mini-implants are successfully used as anchorage devices in orthodontics. The miniimplants alloys are subject to corrosion process in the oral environment. The metallic ions release may lead to adverse physiological effects, including citotoxicity,genotoxicity, carcinogenesis and allergic reactions. The aim of this study was to evaluate the ions release and
Publicado em: 2007
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26. Analysis of presence of HOXA7, HOC6 and TGIF transcripts in oral squamous cell carcinoma. / "Análise da presença de transcritos dos genes HOXA7, HOXC6 e TGIF em carcinomas epidermóides de boca"
Homeobox genes comprise a family of developmental regulators that are vital for several aspects of growth and differentiation. Recently HOXA7, HOXC6 and TGIF genes have been implicated with carcinogenesis and tumoral progression. However their involvement with oral squamous cell carcinomas (OSCC) has not been demonstrated yet. The possible presence of HOXA7,
Publicado em: 2006
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27. Análise molecular do gene WWOX no carcinoma de células escamosas da cavidade bucal
Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral cavity, representing approximately 90% of all oral carcinomas. It is acknowledged that oral carcinogenesis is a multi-step process of accumulated genetic damage, such as activation of oncogenes, tumor suppressor genes inactivation, and loss of heterozygosity at numerous chr
Publicado em: 2005
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28. Espectroscopia de fluorescência na detecção de lesões quimicamente induzidas por agente carcinogênico na borda lateral da língua-estudo in vivo / Fluorescence spectroscopy to detection of chemically induced lesion at the lateral vorder of the tongue - in vivo study.
The diagnostic validity of the fluorescence spectroscopy in the discrimination of induced lesions at lateral border of the tongue of hamsters was investigated in this study. The animal model using chemical induction with DMBA (dimethylbenzanthracene) was chosen for the carcinogenesis phases comparable to the ones observed at oral cancer development in humans
Publicado em: 2005
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29. "Análise da expressão e mecanismos de ação da proteína AKt em células cultivadas de carcinoma epidermóide bucal humano" / Analysis of the expression and pathways of Akt protein in human squamous cell carcinoma cultured cells
Como neoplasia maligna que mais acomete a cavidade oral, o carcinoma epidermóide gera infinidade de estudos acerca de sua gênese e progressão. O variado perfil genético e protéico observado leva a freqüente insucesso nas terapias adotadas, contribuindo para pobres prognósticos. Este estudo visa compreender melhor o papel da proteína Akt, tida como ch
Publicado em: 2005
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30. Efeito da imunossupressão pela ciclosporina A (CsA) sobre a carcinogenese pelo 4NQO nos tecidos bucais de ratos
Cyclosporin A (CsA) is an imunossupressive agent extensively used for the treatment and prevention of allograft rejection in transplanted recipients. Malignant disease are related between the side effects of CsA treatment. The aim of this investigation was to avaliate oral carcinogenesis in rats receiving CsA treatment (10 mg/Kg weightlday), and topic applic
Publicado em: 2002
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31. Biological activities of Curcuma longa L.
There are several data in the literature indicating a great variety of pharmacological activities of Curcuma longa L. (Zingiberaceae), which exhibit anti-inflammatory, anti-human immunodeficiency virus, anti-bacteria, antioxidant effects and nematocidal activities. Curcumin is a major component in Curcuma longa L., being responsible for its biological action
Memórias do Instituto Oswaldo Cruz. Publicado em: 2001-07
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32. Cyclin D1 overexpression and p53 inactivation immortalize primary oral keratinocytes by a telomerase-independent mechanism
The immortalization of human cells is a critical step in multistep carcinogenesis. Oral-esophageal carcinomas, a model system to investigate molecular mechanisms underlying squamous carcinogenesis, frequently involve cyclin D1 overexpression and inactivation of the p53 tumor suppressor. Therefore, our goal was to establish the functional role of cyclin D1 ov
American Society for Clinical Investigation.
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33. Skp2 is oncogenic and overexpressed in human cancers
Skp2 is a member of the F-box family of substrate-recognition subunits of SCF ubiquitin–protein ligase complexes that has been implicated in the ubiquitin-mediated degradation of several key regulators of mammalian G1 progression, including the cyclin-dependent kinase inhibitor p27, a dosage-dependent tumor suppressor protein. In this study, we examin
The National Academy of Sciences.
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34. Sequential expression and cooperative interaction of c-Ha-ras and c-erbB genes in in vivo chemical carcinogenesis.
The level of expression of several cellular protooncogenes is examined at different stages of 7,12-dimethylbenzanthracene (DMBA)-induced tumor development in hamster buccal pouch epithelium (HBPE). Results presented demonstrate overexpression of c-Ha-ras gene at a very early stage of tumor development, and this elevated level of expression of the gene persis
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35. Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols
Development of effective chemopreventive agents against prostate cancer (CaP) for humans requires conclusive evidence of their efficacy in animal models that closely emulates human disease. The autochthonous transgenic adenocarcinoma of the mouse prostate (TRAMP) model, which spontaneously develops metastatic CaP, is one such model that mimics progressive fo
The National Academy of Sciences.
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36. Aromatic hydrocarbon responsiveness-receptor agonists generated from indole-3-carbinol in vitro and in vivo: comparisons with 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Indole-3-carbinol (I3C) is a secondary plant metabolite produced in vegetables of the Brassica genus, including cabbage, cauliflower, and brussels sprouts. I3C is both an anti-initiator and a promoter of carcinogenesis. Consumption of I3C by humans and rodents can lead to marked increases in activities of cytochrome P-450-dependent monooxygenases and in a va