Myotoxins
Mostrando 1-11 de 11 artigos, teses e dissertações.
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1. Alpha-type phospholipase A2 inhibitors from snake blood
Abstract It is of popular and scientific knowledge that toxins from snake venom (among them the PLA2 and myotoxins) are neutralized by various compounds, such as antibodies and proteins purified from animal blood. Venomous and nonvenomous snakes have PLA2 inhibitory proteins, called PLIs, in their blood serum. One hypothesis that could explain the presence o
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 27/04/2017
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2. General characterization of venom from the Moroccan snakes Macrovipera mauritanica and Cerastes cerastes
Ophidian envenomation accidents constitute a serious public health problem in many countries around the globe. Over 5 million such accident cases occur each year causing more than 100,000 deaths. In Africa, more than 20,000 deaths per year are registered while 400,000 envenomation victims retain severe and permanent functional sequelae. In Morocco, snakebite
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 2012
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3. Neutralization of pharmacological and toxic activities of Bothrops jararacussu snake venom and isolated myotoxins by Serjania erecta methanolic extract and its fractions
Most of the snakebites recorded in Brazil are caused by the Bothrops genus. Given that the local tissue damage caused by this genus cannot be treated by antivenom therapy, numerous studies are focusing on supplementary alternatives, such as the use of medicinal plants. Serjania erecta has already demonstrated anti-inflammatory, antiseptic and healing propert
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2011
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4. Evaluation of Antiophidian Activity from Anacardium humile Plant Extract: Isolation and Phytochemical Characterization of the Gallic Acid with Antimyotoxic Potential / Avaliação da atividade antiofídica do extrato vegetal de Anacardium humile:Isolamento e caracterização fitoquímica do ácido gálico com potencial antimiotóxico
Os envenenamentos ofídicos constituem um problema relevante de saúde pública em diversas regiões do mundo, particularmente em países da zona tropical e neotropical. A fisiopatologia do acidente ofídico é constituída por uma série de eventos complexos tanto a nível local quanto sistêmico, e o soro antiofídico é o único tratamento utilizado. No e
Publicado em: 2011
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5. Low-level laser therapy decreases local effects induced by myotoxins isolated from Bothrops jararacussu snake venom
The prominent myotoxic effects induced by Bothrops jararacussu crude venom are due, in part, to its polycationic myotoxins, BthTX-I and BthTX-II. Both myotoxins have a phospholipase A2 structure: BthTX-II is an active enzyme Asp-49 PLA2, while BthTX-I is a Lys-49 PLA2 devoid of enzymatic activity. In this study, the effect of low-level laser therapy (LLLT),
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2010
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6. Anti-inflammatory activity of Blutaparon portulacoides ethanolic extract against the inflammatory reaction induced by Bothrops jararacussu venom and isolated myotoxins BthTX-I and II
This article reports the anti-inflammatory effect of Blutaparon portulacoides (B. portulacoides), specifically the ethanolic extract of its aerial parts, on the edema formation and leukocyte influx caused by Bothrops jararacussu (B. jararacussu) snake venom and Bothropstoxin-I and II (BthTX-I and II) isolated from this venom as an alternative treatment for B
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2009
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7. Functional and structural characterization of phospholipase A2 inhibitors from Bothrops jararacussu snake plasma / Caracterização funcional e estrutural de inibidores de fosfolipases A2 isolados do plasma de serpente Bothrops jararacussu
As fosfolipases A2 (PLA2s) de peçonhas de serpentes compreendem um grupo de enzimas de massas moleculares variáveis entre 14.000 e 18.000, e são responsáveis por vários efeitos tóxicos induzidos pela peçonha destes animais, tornando-se necessária a busca por inibidores naturais de PLA2¬s. O presente trabalho propôs a caracterização bioquímica, f
Publicado em: 2009
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8. Renal effects promoted by myotoxins and lectins isolated from the snake venoms of Bothrops jararacusu and Bothrops moojeni. The role of cyclooxigenase and endothelin / Efeitos renais de miotoxinas e lectinas purificadas dos venenos das serpentes Bothrops jararacussu e Bothrops moojeni. Papel da ciclooxigenase e endotelina
Acute renal failure is one of the most common systemic complications after snakebite. However, its pathogenesis remains obscure. In this study, we evaluated the renal effects of Bothrops jararacussu myotoxins I and II (Bthtx-I Lys 49 and BthtxII, Asp 49), Bothrops moojeni myotoxin I and the lectins from Bothrops moojeni and Bothrops jararacussu. Attempting t
Publicado em: 2006
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9. Efeito citotÃxico e antitumoral da Bothropstoxina-I e da Crotamina
BthTX-I and Crotamine are non enzymatic myotoxins isolated from Bothrops jararacussu venom and Crotalus durissus terrificus respectively. The aims of this work were to evaluate the action of BthTX-I (native or modified) and crotamine (in vitro) on cells lines and on the bacterial proliferation; and the native and modified BthTX-I on the growth of the tumor i
Publicado em: 2005
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10. Miotoxinas PLA2 "like" de Bothrops pirajai : caracterização molecular e funcional
The genus Bothrops comprises severaI species, which are widely distributed in South and North America. Among the bioactive proteins from Bothrops venoms, the phospholipase A2(PLA2,E.C.3.1.14) and PLA2-likemyotoxin are outstanding as their major components. Phospholipase A2Sare calcium-dependent enzymes which hydrolyze the 2 ester bonds of 1,2 diacyl-3sn phos
Publicado em: 2000
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11. Mitochondria and sarcoplasmic reticulum as model targets for neurotoxic and myotoxic phospholipases A2
Certain neurotoxins and myotoxins from snake venoms have phospholipase A2 activity (phosphatide 2-acylhydrolase, EC 3.1.1.4), which appears to be necessary for their toxicity. Several of these toxins inhibit the net uptake of Ca2+ into sarcoplasmic reticulum vesicles and brain mitochondria. We have obtained evidence that the ability to inhibit this Ca2+ upta