Myotoxin
Mostrando 1-12 de 17 artigos, teses e dissertações.
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1. Alpha-type phospholipase A2 inhibitors from snake blood
Abstract It is of popular and scientific knowledge that toxins from snake venom (among them the PLA2 and myotoxins) are neutralized by various compounds, such as antibodies and proteins purified from animal blood. Venomous and nonvenomous snakes have PLA2 inhibitory proteins, called PLIs, in their blood serum. One hypothesis that could explain the presence o
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 27/04/2017
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2. Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect
Abstract Background Arthritis is a set of inflammatory conditions that induce aching, stiffness, swelling, pain and may cause functional disability with severe consequences to the patient’s lives. These are multi-mediated pathologies that cannot be effectively protected and/or treated. Therefore, the aim of this study was to establish a new model of acut
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 27/04/2017
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3. Endogenous phospholipase A2 inhibitors in snakes: a brief overview
Abstract The blood plasma of numerous snake species naturally comprises endogenous phospholipase A2 inhibitors, which primarily neutralize toxic phospholipases A2 that may eventually reach their circulation. This inhibitor type is generally known as snake blood phospholipase A2 inhibitors (sbPLIs). Most, if not all sbPLIs are oligomeric glycosylated proteins
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 19/01/2017
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4. Antitumor potential of the myotoxin BthTX-I from Bothrops jararacussu snake venom: evaluation of cell cycle alterations and death mechanisms induced in tumor cell lines
Abstract Background Phospholipases A 2 (PLA 2 s) are abundant components of snake venoms that have been extensively studied due to their pharmacological and pathophysiological effects on living organisms. This study aimed to assess the antitumor potential of BthTX-I, a basic myotoxic PLA 2isolated from Bothrops jararacussu venom, by evaluating in vitro pro
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 22/12/2015
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5. Biological characterization of a myotoxin phosphoplipase A2 homologue purified from the venom of the snake Bothrops moojeni
A myotoxin phospholipase A2 homologue, BmooMtx, was isolated from the venom of Bothrops moojeni by a combination of ion-exchange chromatography on DEAE-Sephacel column and gel filtration on Sephadex G-75. SDS-PAGE showed the enzyme to be a monomer with a molecular weight of 16,500. BmooMtx induced release of creatine kinase and morphological analyses indicat
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2011
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6. Caracterização da inflamação articular induzida por fosfolipase A2 - grupo II A: determinação das alterações histopatológicas, comportamentais e mediação química. / Characterization of joint inflammation induced by phospholipase A2 - group II: determination of the histopathological changes, behavioral and chemical mediation.
As fosfolipases A2 secretadas, particularmente do grupo II são abundantes nos venenos de serpentes, incluindo o gênero Bothrops e estão envolvidas em diversos processos fisiológicos e fisiopatológicos, como inflamação e dor, incluindo artrite. Contudo, não está totalmente caracterizado o papel da FLA2 para a gênese e manutenção dos quadros de inf
Publicado em: 2010
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7. PLA2 D49 and K49 mitoxins from the venom of Bothrops brazili snake : purification and structural and funcional characterization / Miotoxinas PLA 2 D49 e K49 do veneno total de Bothrops brazili : purificação e caracterização estruturação e funcional
As enzimas PLA2 provenientes de veneno de serpentes são intensamente estudadas devido a que os envenenamentos constituem um dos principais problemas de saúde em muitos paises. Por outro lado, estas toxinas ajudam a revelar aspectos desconhecidos da fisiologia celular e tisular. Neste trabalho, apresentamos a purificação e a caracterização bioquímica e
Publicado em: 2009
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8. Insights of local tissue damage and regeneration induced by BnSP-7, a myotoxin isolated from Bothrops pauloensis snake venom: A study of release of pro-inflammatory cytokines and expression of Matrix Metalloproteinases (MMP2 and MMP9). / Aspectos da lesão tecidual local e da regeneração induzidas pela BnSP-7, uma miotoxina isolada da peçonha da serpente Bothrops pauloensis: um estudo da liberação de citocinas pró-inflamatórias e da expressão de metaloproteases de matriz (MMP-9 e MMP-2)
Envenenamentos causados por serpentes do gênero Bothrops São caracterizados por lesão tecidual local proeminente devido à mionecrose, hemorragia e edema. A lesão tecidual aguda induzida por essas peçonhas ocorre devido à ação de diferentes toxinas presentes nas peçonhas, entre elas as fosfolipases A2 (PLA2) miotóxicas possuem um importante papel.
Publicado em: 2008
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9. Isolation, purification and pharmalogical and biochemical characterization of a new PLA2 (Bp12) from Bothrops pauloensis venom / Isolamento, purificação e caracterização bioquimica e farmacologica de uma nova fosfolipase A2 (Bp12) do veneno de Bothrops pauloensis
The myotoxic effects caused by bothropics venoms are unquestionable by their exuberant clinic manifestation and are extensively related in literature, since the neurotoxic effects have been described in vitro conditions, in nerve-muscle preparations, with little or neither clinic evidence. The aim of this study was to contribute for the knowledge about the p
Publicado em: 2008
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10. Pharmacological characterization of ASP49 PLA2 isolated from Bothrops pauloensis venom / Caracterização farmacologica de uma fosfolipase A2 ASP49 isolada do veneno de Bothrops pauloensis
Bothropic venom has several substances necessary to serpent survival, among them, one of the most widely studied are phospholipase A2 enzymes, that hydrolise sn-2 from membrane phospholipids, releasing lysophospholipids and fatty acids, which beyond playing a biological action in the lipid digestion process, also exhibit a wide variety of pharmacological eff
Publicado em: 2008
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11. The influence of heparin at a low concentration agaist the myotoxicity of Bothrops jararacussu and bothropstoxin-I / A influencia da heparina em baixa concentração sobre a miotoxicidade do veneno de Bothrops jararacussu e bothropstoxina da heparina -I
Bothrops jararacussu venom (Bjssu) and its myotoxin bothropstoxin-I (BthTX-I) induce neurotoxicity and myotoxicity. Since the treatment with the antivenom is weakly efficient against the myotoxicity, many reports concentrate on studies utilizing substances that neutralize the myotixicity activity induced by the venom, including heparin. The objectives of thi
Publicado em: 2007
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12. Renal effects promoted by myotoxins and lectins isolated from the snake venoms of Bothrops jararacusu and Bothrops moojeni. The role of cyclooxigenase and endothelin / Efeitos renais de miotoxinas e lectinas purificadas dos venenos das serpentes Bothrops jararacussu e Bothrops moojeni. Papel da ciclooxigenase e endotelina
Acute renal failure is one of the most common systemic complications after snakebite. However, its pathogenesis remains obscure. In this study, we evaluated the renal effects of Bothrops jararacussu myotoxins I and II (Bthtx-I Lys 49 and BthtxII, Asp 49), Bothrops moojeni myotoxin I and the lectins from Bothrops moojeni and Bothrops jararacussu. Attempting t
Publicado em: 2006