Micronuclei Assay
Mostrando 1-12 de 35 artigos, teses e dissertações.
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1. Evaluation of hydroxyurea genotoxicity in patients with sickle cell disease
RESUMO Objetivo Avaliar o efeito da indução de danos ao DNA em células monocelulares do sangue periférico de pacientes com doença falciforme, genótipos SS e SC, tratados com hidroxiureia. Métodos Os sujeitos da pesquisa foram divididos em dois grupos: um de 22 pacientes com doença falciforme genótipos SS e SC tratados com hidroxiureia, e o outro c
Einstein (São Paulo). Publicado em: 09/09/2019
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2. CYTOTOXIC EFFECTS OF ARIPIPRAZOLE ON MKN45 AND NIH3T3 CELL LINES AND GENOTOXIC EFFECTS ON HUMAN PERIPHERAL BLOOD LYMPHOCYTES
RESUMO CONTEXTO: O câncer gástrico é conhecido como o quarto câncer mais comum. Os tratamentos atuais para o câncer danificaram os tecidos sensíveis do corpo saudável e, em muitos casos, o cancro será recorrente. Portanto, a necessidade de tratamentos que são mais eficazes é desejada. Recentemente, os pesquisadores mudaram sua atenção para os a
Arq. Gastroenterol.. Publicado em: 26/08/2019
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3. RESISTANCE EXERCISE PROTOCOL DOES NOT CAUSE ACUTE GENOTOXIC EFFECTS IN TRAINED INDIVIDUALS
RESUMO Introdução: O treinamento resistido, principalmente a musculação, vem progressivamente ganhando novos adeptos em todo o mundo. Apesar de haver um significativo aumento no número de pesquisas e na literatura disponível sobre o assunto, o treinamento resistido vem passando por um importante processo de evolução. O metabolismo anaeróbico, que c
Rev Bras Med Esporte. Publicado em: 2019-04
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4. Mycobacterium tuberculosis promotes genomic instability in macrophages
BACKGROUND Mycobacterium tuberculosis is an intracellular pathogen, which may either block cellular defensive mechanisms and survive inside the host cell or induce cell death. Several studies are still exploring the mechanisms involved in these processes. OBJECTIVES To evaluate the genomic instability of M. tuberculosis-infected macrophages and compare it
Mem. Inst. Oswaldo Cruz. Publicado em: 2018-03
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5. Genotoxicity Evaluation of Dipotassium -Trioxohydroxytetrafluorotriborate, K2(B3O3F4OH), in Human Lymphocyte Cultures and Mice Reticulocytes
ABSTRACT Genotoxic effects of inorganic molecule dipotassium-trioxohydroxytetrafluorotriborate, K2(B3O3F4OH), a promising new therapeutic for the epidermal changes treatment, have been evaluated. In vitro analysis included evaluation of genotoxic and cytotoxic potential of K2(B3O3F4OH) in concentrations of 0.01, 0.02, 0.05 and 0.06 mg/mL applying cytokinesis
Braz. arch. biol. technol.. Publicado em: 31/10/2016
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6. Genotoxic and mutagenic effects of polluted surface water in the midwestern region of Brazil using animal and plant bioassays
Abstract This study aimed to evaluate DNA damage in animal and plant cells exposed to water from the Água Boa stream (Dourados, Mato Grosso do Sul, Brazil) by using bioassays, and to identify the chemical compounds in the water to determine the water quality in the area. Through the cytotoxicity bioassay with Allium cepa, using micronucleus test, and comet
Genet. Mol. Biol.. Publicado em: 31/10/2016
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7. Evaluation of the genotoxicity and mutagenicity of Ca3SiO5-based cement
Abstract Ca3SiO5 is new cement based on the composition of Portland that has been developed to have superior physicochemical and biological properties. In a clinical evaluation, the cement did not appear to have cytotoxic properties and allowed for the proliferation of pulp cells and gingival fibroblasts. However, no previous studies have evaluated the genot
Braz. oral res.. Publicado em: 18/08/2016
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8. Comparative study of curcumin and curcumin formulated in a solid dispersion: Evaluation of their antigenotoxic effects
Abstract Curcumin (CMN) is the principal active component derived from the rhizome of Curcuma longa (Curcuma longa L.). It is a liposoluble polyphenolic compound that possesses great therapeutic potential. Its clinical application is, however, limited by the low concentrations detected following oral administration. One key strategy for improving the solubil
Genet. Mol. Biol.. Publicado em: 03/11/2015
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9. Occupational exposure of workers to pesticides: Toxicogenetics and susceptibility gene polymorphisms
Farm workers are often exposed to pesticides, which are products belonging to a specific chemical group that affects the health of agricultural workers and is mostly recognized as genotoxic and carcinogenic. The exposure of workers from Piauí, Brazil, to these hazardous chemicals was assessed and cytogenetic alterations were evaluated using the buccal micro
Genet. Mol. Biol.. Publicado em: 2015-09
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10. Acute genotoxicity analysis in vivo of the aqueous extract of Maytenus guyanensis Amazonian chichuá
Abstract The species Maytenus guyanensis Klotzsch ex Reissek, Celastraceae, present a wide variety of possible pharmacological activities and its roots and stems are used by popular medicine in the western Amazon rainforest. Few studies have demonstrated the genotoxic safety of the popular use of this species, and owing to this, the present study aimed to pe
Rev. bras. farmacogn.. Publicado em: 2015-04
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11. Avaliação da mutagenicidade dos corantes Sudan III, Vat Green 3, Reactive Orange 16 e Reactive Black 5 por meio do ensaio de micronúcleos em células HepG2 / Evaluation of the mutagenicity of the dyes Sudan III, Vat Green 3, Reactive Orange 16, and Reactive Black 5 by using the micronucleus asay in HepG2 cells
The colors have always caused fascination in mankind. Throughout history, colored compounds have always been considered attractive tools in industrial activities. The synthetic dyes are widely used in textile industry, paper and photography printing, in pharmaceutical, food, and cosmetic industries. These compounds are considered important environmental cont
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/03/2012
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12. Genomic instability in patients with type 2 diabetes mellitus on hemodialysis
OBJECTIVE: A previous study by our research group evaluated the levels of DNA damage using the comet assay in hemodialysis patients with type 2 diabetes mellitus. The same blood samples were also evaluated using the cytochalasin B micronucleus assay. A comparison of the results of the two assays is presented here. METHODS: Whole blood samples were collected
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2012