Acute genotoxicity analysis in vivo of the aqueous extract of Maytenus guyanensis Amazonian chichuá

AUTOR(ES)

Meneguetti, Dionatas Ulises de Oliveira, Lima, Renato Abreu, Silva, Francisco Carlos da, Passarini, Guilherme Matos, Facundo, João Bezerra, Pagotto, Rubiani de Cassia, Militão, Júlio Sancho Linhares Teixeira, Facundo, Valdir Alves

FONTE

Rev. bras. farmacogn.

DATA DE PUBLICAÇÃO

2015-04

RESUMO

Abstract The species Maytenus guyanensis Klotzsch ex Reissek, Celastraceae, present a wide variety of possible pharmacological activities and its roots and stems are used by popular medicine in the western Amazon rainforest. Few studies have demonstrated the genotoxic safety of the popular use of this species, and owing to this, the present study aimed to perform an analysis of the acute genotoxicity in vivo of the aqueous extract of M. guyanensis. Male and female mice from Mus musculus species, of weights ranging from 20 to 40 g, organized in eight groups with different treatments were used. The aqueous extracts of the bark of M. guyanensis were administered orally by gavage with 0.1 ml of the test substance per 10 g of the animal, followed by performance of comet assay in peripheral blood, PCE/NCE correlation and occurrence of micronuclei in the bone marrow. It was found that the aqueous extract of M. guyanensis, with ten times higher concentration than those used in ethnopharmacology, did not present genotoxic effect and, moreover, it has antigenotoxic action in mice treated acutely. Further studies regarding bioaccumulation and chronic effects of this species are suggested, in order to improve the understanding of its mechanism of action, ensuring the efficacy and safety of its utilization and developing phytotherapics and drugs.

Documentos Relacionados

• In vivo and in vitro genotoxicity studies of aqueous extract of Xanthium spinosum
• ASPECTS ANATOMICAL AND ETHNOPHARMACOLOGICAL OF STEM AND ROOT OF Maytenus guyanensis Klotzsch ex Reissek (CELASTRACEAE)
• Screening of the in vitro antileishmanial activities of compounds and secondary metabolites isolated from Maytenus guianensis Klotzsch ex Reissek (Celastraceae) chichuá Amazon
• Genotoxicity and acute and subchronic toxicity studies of a standardized methanolic extract of Ficus deltoidea leaves
• Genotoxicity test of Maytenus rigida and Aristolochia birostris in the radicular meristem of the onion, Allium cepa