M Tor
Mostrando 1-12 de 313 artigos, teses e dissertações.
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1. Long non-coding RNA HOTAIR induces the PI3K/AKT/mTOR signaling pathway in breast cancer cells
SUMMARY OBJECTIVE: The phosphoinositide 3-kinase/protein kinase AKT/mammalian target of rapamycin signaling pathway is essential for proper cellular metabolism and cell growth. However, aberrant activation of this pathway has been linked to the progression and metastasis of breast cancer. Recently, the role of long non-coding RNAs in interfering with the ce
Revista da Associação Médica Brasileira. Publicado em: 2022
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2. SARS-CoV-2 infection in kidney transplant recipients: clinical impact and outcomes - a single center experience
RESUMO Introdução: Receptores de transplante renal são um subgrupo de doentes com maior risco de apresentar formas críticas de infecção por Síndrome Respiratória Aguda Grave pelo Coronavirus-2 (SARS-CoV-2) e piores outcomes devido ao tratamento imunossupressor. Aqui, apresentamos dados de uma coorte de um único centro de receptores de transplante r
Brazilian Journal of Nephrology. Publicado em: 2022
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3. Polydatin protects H9c2 cells from hypoxia-induced injury via up-regulating long non-coding RNA DGCR5
Polydatin (PD), a monocrystalline polyphenolic drug mainly found in the roots of Polygonum cuspidatum, has various pharmacological activities. Long non-coding RNAs (lncRNA) DiGeorge syndrome critical region gene 5 (DGCR5) was found to participate in the suppression of multiple cancers. Here, we proposed to study the effect of PD on myocardial infarction (MI)
Braz J Med Biol Res. Publicado em: 05/12/2019
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4. Oxiracetam ameliorates cognitive deficits in vascular dementia rats by regulating the expression of neuronal apoptosis/autophagy-related genes associated with the activation of the Akt/mTOR signaling pathway
Oxiracetam (ORC) is a commonly used nootropic drug for improving cognition and memory impairments. The therapeutic effect and underlying mechanism of ORC in vascular dementia (VaD) treatment remain unknown. In this study, 3-month-old male Sprague-Dawley rats with permanent bilateral common carotid artery occlusion-induced VaD were treated orally with low (10
Braz J Med Biol Res. Publicado em: 07/11/2019
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5. Short-term creatine supplementation changes protein metabolism signaling in hindlimb suspension
The effect of a short-term creatine supplementation on hindlimb suspension (HS)-induced muscle atrophy was investigated. Creatine monohydrate (5 g/kg b.w. per day) or placebo, divided in 2 daily doses, was given by oral gavage for 5 days. Rats were maintained in HS with dietary supplementation concomitantly for 5 days. Body weight, soleus and EDL muscle mass
Braz J Med Biol Res. Publicado em: 07/10/2019
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6. Mechanisms by Which Metabolic Reprogramming in GSD1 Liver Generates a Favorable Tumorigenic Environment
Abstract Glycogen storage disease type 1 (GSD1) is an inherited disorder caused by impaired glucose 6-phosphatase activity. This impairment translates into the inhibition of endogenous glucose production and the subsequent accumulation of cellular glucose 6-phosphate. Excess glucose 6-phosphate enhances glycolysis, increases the production of fatty acids, ur
J. inborn errors metab. screen.. Publicado em: 30/05/2019
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7. EFFECTS OF PILOT HOLE DIAMETER ON SCREW-DRIVING TORQUES IN MEDIUM DENSITY FIBERBOARD
ABSTRACT This study investigated the effects of pilot-hole diameter in medium density fiberboard (MDF) on the characterization of screw-driving torques. The factors investigated were the embedded screw orientation and pilot hole diameter. Based on the curves obtained from screw-driving process, the measurements of the seating torque (SET) and stripping torqu
CERNE. Publicado em: 20/05/2019
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8. Effect of lncRNA HULC knockdown on rat secreting pituitary adenoma GH3 cells
Pituitary adenoma is one of the most common tumors in the neuroendocrine system. This study investigated the effects of long non-coding RNAs (lncRNAs) highly up-regulated in liver cancer (HULC) on rat secreting pituitary adenoma GH3 cell viability, migration, invasion, apoptosis, and hormone secretion, as well as the underlying potential mechanisms. Cell tra
Braz J Med Biol Res. Publicado em: 15/04/2019
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9. SUSCEPTIBILIDADE DE Staphylococcus aureus ISOLADOS DE LEITE CRU A ANTIBIÓTICOS COMERCIAIS
Resumo O leite possui extremo valor na dieta humana e constitui um excelente substrato para o crescimento de grande diversidade de microrganismos, dentre eles o Staphylococcus aureus, frequentemente encontrado no leite cru, e que se destaca como um dos microrganismos mais prevalentes em casos de mastite bovina no mundo. Objetivou-se avaliar a sensibilidade d
Ciênc. anim. bras.. Publicado em: 18/10/2018
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10. Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis
The insulin receptor substrate (IRS) proteins are a family of cytoplasmic proteins that integrate and coordinate the transmission of signals from the extracellular to the intracellular environment via transmembrane receptors, thus regulating cell growth, metabolism, survival and proliferation. The PI3K/AKT/mTOR and MAPK signaling pathways are the best-charac
Clinics. Publicado em: 11/10/2018
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11. Pioglitazona Induz Apoptose e Inibe Hipertrofia de Cardiomiócitos pela Via de Sinalização do VEGFR-2
Resumo Fundamento: A pioglitazona tem sido amplamente utilizada como droga sensibilizadora da insulina para melhorar o controle glicêmico em pacientes com diabetes mellitus tipo 2. No entanto, o risco cardiovascular bem como os efeitos protetores da pioglitazona ainda são controversos. Objetivos: Neste estudo, investigamos se os efeitos da pioglitazona s
Arq. Bras. Cardiol.. Publicado em: 02/07/2018
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12. Avaliação dos 1000 transplantes renais realizados no Hospital das Clínicas da Faculdade de Medicina de Botucatu (HCFMB) da UNESP e a sua evolução ao longo dos anos
RESUMO Introdução: O progresso no transplante renal tem sido evidente ao longo dos anos, assim como seus benefícios para os pacientes. Objetivos: Avaliar os 1000 transplantes renais realizados no Hospital das Clínicas da Faculdade de Medicina de Botucatu, subdividindo os pacientes em diferentes períodos, de acordo com a imunossupressão vigente, e ava
J. Bras. Nefrol.. Publicado em: 04/06/2018