M Tor
Mostrando 13-24 de 313 artigos, teses e dissertações.
-
13. Laser de baixa intensidade favorece a regeneração muscular em modelo experimental desnutrido e recuperado
RESUMO A terapia por laser de baixa intensidade (Low-Level Laser Therapy - LLLT) é utilizada com frequência nas lesões musculares, mas precisa ser investigada em modelo de desnutrição. O objetivo desse estudo foi analisar os efeitos da LLLT na regeneração muscular de ratos submetidos à desnutrição e recuperação proteica. Foram utilizados 40 ratos
Fisioter. Pesqui.. Publicado em: 2018-06
-
14. LncRNA HULC mediates radioresistance via autophagy in prostate cancer cells
Prostate cancer (PCa) is the second leading cause of cancer death in men. Irradiation is one of the available options for treatment of PCa, however, approximately 10–45% of PCa are resistant to irradiation. We aimed to explore the role of long non-coding RNA highly upregulated in liver cancer (HULC) in the sensitivity of PCa cells to irradiation. Survival
Braz J Med Biol Res. Publicado em: 23/04/2018
-
15. Efficacy of targeted therapy for advanced renal cell carcinoma: A systematic review and meta-analysis of randomized controlled trials
ABSTRACT We conducted a systematic review and meta-analysis of the literature on the efficacy of the targeted therapies in the treatment of advanced RCC and, via an indirect comparison, to provide an optimal treatment among these agents. A systematic search of Medline, Scopus, Cochrane Library and Clinical Trials unpublished was performed up to Jan 1, 2015 t
Int. braz j urol.. Publicado em: 2018-04
-
16. Interleukin-27 augments the inhibitory effects of sorafenib on bladder cancer cells
Both sorafenib and interleukin-27 (IL-27) are antineoplastic drugs. This study aimed to investigate the synergistic effect of these two drugs on bladder cancer cells. HTB-9 and T24 cells were stimulated with IL-27 (50 ng/mL), sorafenib (2 μM) or the synergistic action of these two drugs. The cells without treatment acted as control. Cell proliferation, apop
Braz J Med Biol Res. Publicado em: 20/07/2017
-
17. microRNA-142-3p inhibits apoptosis and inflammation induced by bleomycin through down-regulation of Cox-2 in MLE-12 cells
microRNA (miR)-142-3p is implicated in malignancy and has been identified as a biomarker for aggressive and recurrent lung adenocarcinomas. This study aimed to evaluate the inhibitory effect of miR-142-3p on apoptosis and inflammation induced by bleomycin in MLE-12 cells. MLE-12 cells were first transfected either with miR-142-3p mimic or miR-142-3p inhibito
Braz J Med Biol Res. Publicado em: 03/07/2017
-
18. Análise crítica da perda do enxerto e óbito em receptores de transplante renal tratados com inibidores da mTOR
Resumo Estudos de registro e revisões sistemáticas mostraram um aumento de mortalidade e perda do enxerto nos pacientes em uso dos inibidores da mTOR (imTOR) em comparação a regimes baseados nos inibidores de calcineurina (iCN). A maioria destes estudos reuniu dados de ensaios clínicos iniciais utilizando diferentes estratégias, tais como a combinaçã
J. Bras. Nefrol.. Publicado em: 2017-03
-
19. EXPRESSÃO DOS TRANSPORTADORES DE AMINOÁCIDOS ASCT2 (SLC1A5) E LAT1 (SLC7A5) EM ASTROCITOMAS
OBJETIVO: ASCT2 e LAT1 são transportadores de aminoácidos envolvidos no transporte de glutamina e desempenham um papel no crescimento tumoral. Estudos prévios mostraram uma associação de ASCT2 com proliferação celular através da maquinaria de tradução do mTOR; tem sido mostrado que o LAT1 é um marcador prognóstico devido à sua relação com inv
MedicalExpress (São Paulo, online). Publicado em: 2016-12
-
20. Insulin Promotes the Expression of the Gluconeogenic Rate-Limiting Enzymes Phosphoenolpyruvate Carboxykinase (Pepck) and Glucose 6-Phosphatase (G6pase) through PI3k/Akt/mTOR Signaling Pathway in Goose Hepatocytes
ABSTRACT To identify what makes insulin have an activating or inhibiting role in gluconeogenesis in goose hepatocytes and whether insulin regulates PEPCK and G6Pase through the PI3k/Akt/mTOR pathway or not, goose primary hepatocytes were isolated and cultured in vitro. After 12h cultured in serum-free medium, hepatocytes were incubated for 24 h in the medium
Rev. Bras. Cienc. Avic.. Publicado em: 2016-09
-
21. Six1 induces protein synthesis signaling expression in duck myoblasts mainly via up-regulation of mTOR
Abstract As a critical transcription factor, Six1 plays an important role in the regulation of myogenesis and muscle development. However, little is known about its regulatory mechanism associated with muscular protein synthesis. The objective of this study was to investigate the effects of overexpression ofSix1 on the expression of key protein metabolism-re
Genet. Mol. Biol.. Publicado em: 2016-03
-
22. CHANGE OF THE MTOR PATHWAY IN TISSUES OF OVERFED GEESE
ABSTRACTThis study aimed at examining the effect of overfeeding on the activity of the mTOR pathway in the liver and muscle tissues of Gang geese. Eighty healthy male Gang geese were reared under the same feeding conditions, and were divided at 14 weeks of age into a control group and an overfed group. All birds were slaughtered after three weeks of over fee
Rev. Bras. Cienc. Avic.. Publicado em: 2015-09
-
23. Uso de sirolimo no tratamento de linfangioleiomiomatose: resposta favorável em pacientes com diferentes manifestações extrapulmonares
OBJETIVO: A linfangioleiomiomatose (LAM) é uma doença rara que é atualmente considerada uma neoplasia de baixo grau com potencial metastático e evolução variável. Os inibidores de mammalian target of rapamycin (mTOR), como o sirolimo e o everolimo, recentemente se tornaram uma opção para o tratamento de pacientes com LAM, especialmente daqueles com
J. bras. pneumol.. Publicado em: 2015-06
-
24. Tuberculose da coluna vertebral no oeste do méxico, 2008-2013
Objetivo: Identificar a prevalência, as características clínicas e a evolução pós-cirúrgica de pacientes com tuberculose vertebral do Instituto Mexicano del Seguro Social, em Jalisco, México, no período de 2008 a 2013.
Coluna/Columna. Publicado em: 2014-12