Indels
Mostrando 13-24 de 55 artigos, teses e dissertações.
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13. Diversificação dos genes do antígeno B de Echinococcus multiocularis em camundongos proficientes e não proficientes quanto à resposta imune mediada por células T
O antígeno B (AgB) é uma proteína polimérica de aproximadamente 160 kDa secretada durante a fase larval dos parasitos do gênero Echinococcus. Sua função provavelmente está relacionada com a evasão da resposta imune do hospedeiro, e tem sido relatado que seus genes apresentam alta diversidade de seqüências, mesmo dentro de um único metacestóide d
Publicado em: 2008
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14. Desenvolvimento e aplicação de polimorfismos de inserção: deleção do cromossomo x em genética forense
Nowadays the human genetic identification its based on the utilization of a set of autosomal markers, the microsatellites, which fulfils the majority of the forensic genetic labs requirements. However, there are some situations when that the usual autosomal microsatellites dont always offer good results. Those situations include cases where the genetic sampl
Publicado em: 2007
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15. Caracterização de loci com variação alélica no genoma de Leishmania braziliensis passíveis de uso em testes diagnósticos e em estudos epidemiológicos. / Characterization of loci with allelic variation in the Leishmania braziliensis genome that could be useful in diagnostics tests and epidemiological studies.
American tegumentary leishmaniasis (ATL) in Bahia, Brazil is an infectious disease caused by L. braziliensis. This species has a high degree of genetic variability, as well as a large spectrum of clinical manifestations of illness. A previous study of parasites isolated from patients from an endemic area demonstrated that the population of L. braziliensis wa
Publicado em: 2006
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16. Neurogenesis and schizophrenia: molecular association study / Neurogênese e esquizofrenia: estudo molecular de associação
A esquizofrenia (EZ) é uma das doenças neuropsiquiátricas mais prevalentes, afetando cerca de 1% da população ao redor do mundo, sendo caracterizada pela presença de delírios, alucinações, disfunção cognitiva e apatia, entre outros. Dentre as hipóteses que procuram explicar as bases biológicas da EZ, a que tem tido um maior embasamento e credibi
Publicado em: 2006
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17. Majority of divergence between closely related DNA samples is due to indels
It was recently shown that indels are responsible for more than twice as many unmatched nucleotides as are base substitutions between samples of chimpanzee and human DNA. A larger sample has now been examined and the result is similar. The number of indels is ≈1/12th of the number of base substitutions and the average length of the indels is 36 nt, includi
The National Academy of Sciences.
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18. Human Diallelic Insertion/Deletion Polymorphisms
We report the identification and characterization of 2,000 human diallelic insertion/deletion polymorphisms (indels) distributed throughout the human genome. Candidate indels were identified by comparison of overlapping genomic or cDNA sequences. Average confirmation rate for indels with a ⩾2-nt allele-length difference was 58%, but the confirmation rate f
The American Society of Human Genetics.
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19. Indel-Based Evolutionary Distance and Mouse–Human Divergence
We propose a method for estimating the evolutionary distance between DNA sequences in terms of insertions and deletions (indels), defined as the per site number of indels accumulated in the course of divergence of the two sequences. We derive a maximal likelihood estimate of this distance from differences between lengths of orthologous introns or other segme
Cold Spring Harbor Laboratory Press.
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20. Occurrence and Consequences of Coding Sequence Insertions and Deletions in Mammalian Genomes
Nucleotide insertion and deletion (indel) events, together with substitutions, represent the major mutational processes of gene evolution. Through the alignment of 8148 orthologous genes from human, mouse, and rat, we have identified 1743 indel events within rodent protein-coding sequences. Using human as an out-group, we reconstructed the mutational event u
Cold Spring Harbor Laboratory Press.
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21. Positive selection on protein-length in the evolution of a primate sperm ion channel
Positive Darwinian selection on advantageous point substitutions has been demonstrated in many genes. We here provide empirical evidence, for the first time, that positive selection can also act on insertion/deletion (indel) substitutions in the evolution of a protein. CATSPER1 is a voltage-gated calcium channel found exclusively in the plasma membrane of th
National Academy of Sciences.
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22. Development of Genome-Wide DNA Polymorphism Database for Map-Based Cloning of Rice Genes1[w]
DNA polymorphism is the basis to develop molecular markers that are widely used in genetic mapping today. A genome-wide rice (Oryza sativa) DNA polymorphism database has been constructed in this work using the genomes of Nipponbare, a cultivar of japonica, and 93-11, a cultivar of indica. This database contains 1,703,176 single nucleotide polymorphisms (SNPs
American Society of Plant Biologists.
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23. Insertions and Deletions Are Male Biased Too: A Whole-Genome Analysis in Rodents
It is presently accepted that, in mammals, due to the greater number of cell divisions in the male germline than in the female germline, nucleotide substitutions occur more frequently in males. The data on mutation bias in insertions and deletions (indels) are contradictory, with some studies indicating no sex bias and others indicating either female or male
Cold Spring Harbor Laboratory Press.
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24. Protein Phylogenies and Signature Sequences: A Reappraisal of Evolutionary Relationships among Archaebacteria, Eubacteria, and Eukaryotes
The presence of shared conserved insertion or deletions (indels) in protein sequences is a special type of signature sequence that shows considerable promise for phylogenetic inference. An alternative model of microbial evolution based on the use of indels of conserved proteins and the morphological features of prokaryotic organisms is proposed. In this mode
American Society for Microbiology.