Immunoglobulin Isotype
Mostrando 1-12 de 401 artigos, teses e dissertações.
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1. Utility of immunoglobulin isotypes against LID-1 and NDO-LID for, particularly IgG1, confirming the diagnosis of multibacillary leprosy
BACKGROUND Leprosy remains a health problem in many countries, with difficulties in diagnosis resulting in delayed treatment and more severe disabilities. Antibodies against several Mycobacterium leprae antigens have, however, shown value as diagnostic and/or prognostic markers. OBJECTIVES The objective of this study was to evaluate serum immunoglobulin
Mem. Inst. Oswaldo Cruz. Publicado em: 26/02/2018
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2. Frequency of Wra antigen and anti-Wra in Brazilian blood donors
BACKGROUND: Wra is a low-incidence antigen, which is antithetical to the high prevalence red blood cell antigen, Wrb. Anti-Wra is a naturally occurring antibody that is found in approximately 1-2% of blood donors. The aim of this study was to determine the frequency of Wra and anti-Wra in Brazilian blood donors.METHODS: A total of 1662 Brazilian blood donors
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-10
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3. Immunohistochemical evaluation of CD20 expression in patients with multiple myeloma
Objective: CD20 expression was reported at different rates in patients with multiple myeloma. The importance of this B-cell antigen for plasma cells is still unknown. This study aimed to investigate CD20 expression of myeloma cells in bone marrow, and any relationship between the stage of disease, isotype and clinical features. Methods: Sixty-one patients w
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-02
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4. Aspectos clínico-laboratoriais na evolução de pacientes com deficiência de imunoglobulina A diagnosticados na infância e de seus familiares / Clinical and laboratorial features from patients with IgA deficiency diagnosed in childhood and from their relatives
A deficiência de imunoglobulina A (DIgA) é a imunodeficiência primária mais comum com prevalência de 1: 223 a 1:1000 em estudos epidemiológcos, sendo menos freqüente em populações asiáticas. As manifestações clínicas variam desde indivíduos assintomáticos até aqueles com manifestações atópicas, auto-imunes ou infecciosas. Entre estas últi
Publicado em: 2008
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5. Avaliação dos níveis séricos de anticorpos IgG e subclasses e IgA, reativos a Porphyromonas gingivalis em indivíduos com periodontites crônica e agressiva.
Periodontitis is an inflammatory oral disease caused by multifactorial intrinsic and extrinsic agents including Gram-negative bacteria, like Porphyromonas gingivalis. This study was undertaken to evaluate immunoglobulin A, Immunoglobulin G and immunoglobulin G isotype serum antibodies against Porphyromonas gingivalis ATCC33277. This study included 89 patient
Publicado em: 2005
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6. Comparison of different monoclonal antibodies against immunosuppressive proteins of Ascaris suum
The extract of Ascaris suum suppresses the humoral and cellular immune responses to unrelated antigens in the mouse. In order to further characterize the suppressive components of A. suum, we produced specific monoclonal antibodies which can provide an important tool for the identification of these proteins. The A. suum immunosuppressive fractions isolated b
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-02
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7. Resposta imune de bovinos vacinados com peptídeo sintético SBm7462 com vistas ao controle do Boophilus microplus (Canestrini, 1887) / Immune response of vaccinated bovine with synthetic peptide SBm7462 to the control of the Boophilus microplus (Canestrini, 1887)
Bovines of three and four month of old age received monthly and subcutaneously, three immunizations of synthetic peptide SBm7462 emulsified in saponin. The development both cellular and humoral immune response were evaluated. Its was achieved identifying the IgG1 and IgG2 antigen specific isotypes, determining of the profile of circulating lymphocytes (CD4+,
Publicado em: 2003
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8. Isotype switching by a microinjected mu immunoglobulin heavy chain gene in transgenic mice.
Immunization of transgenic mice carrying an immunoglobulin mu heavy chain resulted in a response dominated by expression of the transgene variable region. Unexpectedly, in a large proportion of the antibody produced by immunized mice, the transgene variable region was associated with IgG rather than IgM. This demonstrates that the transgene can undergo an is
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9. Two distinct immunoglobulin heavy chain isotypes in a primitive, cartilaginous fish, Raja erinacea.
Immunoglobulin heavy chain genes in Raja erinacea (little skate) are organized in clusters consisting of VH, DH, JH segments and CH exons (1). An immunoglobulin heavy chain mu-like isotype that exhibits 61-91% nucleotide sequence identity in coding segments to the Heterodontus francisci (horned shark) mu-type immunoglobulin is described. The overall length o
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10. Isotype regulation of antibody production: T-cell hybrids can be selectively induced to produce IgG1 and IgG2 subclass-specific suppressive immunoglobulin-binding factors.
T2D4, a T-cell hybrid, spontaneously secretes suppressive immunoglobulin factor(s); when incubated with purified monoclonal mouse immunoglobulins, this hybrid produces high levels of immunoglobulin-binding factors specific for the subclass of the inducing immunoglobulin. Thus, we were able to induce the production of IgG1- or IgG2-specific inhibitory factors
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11. Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse.
We have studied immunoglobulin double-isotype expression in a transgenic mouse (TG.SA) in which expression of the endogenous immunoglobulin heavy chain locus is almost completely excluded by a nonallelic rearranged human mu transgene. By flow-cytometric analyses, we have shown that a small, but significant, portion (about 4%) of transgenic spleen cells expre
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12. A second Xenopus immunoglobulin heavy chain constant region isotype gene