Histones
Mostrando 1-12 de 1103 artigos, teses e dissertações.
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1. How to prevent the malignant progression of bipolar disorder
There is increasing recognition that, in a high percentage of cases, bipolar disorder is a progressive illness. Multiple types of sensitization (or increased reactivity to repetition of the same stimulus) drive illness progression. One of the clearest is that of episode sensitization, where increased numbers of prior episodes are associated with: faster recu
Braz. J. Psychiatry. Publicado em: 2020-10
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2. Dispersion of transposable elements and multigene families: Microstructural variation in Characidium (Characiformes: Crenuchidae) genomes
Abstract Eukaryotic genomes consist of several repetitive DNAs, including dispersed DNA sequences that move between chromosome sites, tandem repeats of DNA sequences, and multigene families. In this study, repeated sequences isolated from the genome of Characidium gomesi were analyzed and mapped to chromosomes in Characidium zebra and specimens from two popu
Genet. Mol. Biol.. Publicado em: 16/07/2018
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3. The histone genes cluster in Rhynchosciara americana and its transcription profile in salivary glands during larval development
Abstract In this work we report the characterization of the Rhynchosciara americana histone genes cluster nucleotide sequence. It spans 5,131 bp and contains the four core histones and the linker histone H1. Putative control elements were detected. We also determined the copy number of the tandem repeat unit through quantitative PCR, as well as the unequivoc
Genet. Mol. Biol.. Publicado em: 10/10/2016
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4. Nucleolus Organizer Regions chromatin architecture and its role in ribosomal genes expression / Arquitetura da cromatina na região organizadora do nucléolo e o seu papel no controle da expressão dos genes ribossomais
O nucléolo é uma organela nuclear responsável pela produção dos ribossomos, através das Regiões Organizadoras do Nucléolo (NORs). Espécies que possuem mais de um par de cromossomos contendo NORs terão, obrigatoriamente, pelo menos um par ativo, sendo as demais NORs funcionais de acordo com a demanda celular. O mecanismo de compensação de dose é
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/09/2011
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5. Chromatin regulation in schistosomes and histone modifying enzymes as drug targets
Only one drug is currently available for the treatment and control of schistosomiasis and the increasing risk of selecting strains of schistosome that are resistant to praziquantel means that the development of new drugs is urgent. With this objective we have chosen to target the enzymes modifying histones and in particular the histone acetyltransferases and
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-11
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6. Retinol-induced changes in the phosphorylation levels of histones and high mobility group proteins from sertoli cells
Chromatin proteins play a role in the organization and functions of DNA. Covalent modifications of nuclear proteins modulate their interactions with DNA sequences and are probably one of the multiple factors involved in the process of switch on/off transcriptionally active regions of DNA. Histones and high mobility group proteins (HMG) are subject to many co
Publicado em: 2010
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7. Modulation of thyroid hormone receptor transactivation by the early region 1A (E1A)-like inhibitor of differentiation 1 (EID1)
Transcriptional activation (TA) mediated by the effect of thyroid hormones on target genes requires co-activator proteins such as the early region 1A (E1A) associated 300 kDa binding protein (p300) and the cAMP response element binding protein (CREB) binding protein (CBP), known as the p300/CBP complex, which acetylate histones 3 and 4 to allow transcription
Genetics and Molecular Biology. Publicado em: 2008
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8. Estudo da expressão dos genes de classe I das histonas desacetilases (HDACs 1,2,3 e 8) em Leucemia Linfóide Aguda de crianças e adolescentes / Class 1 Histone Deacetylases Gene Expression in Childhood Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia (ALL) is a heterogeneous disease with distinct biologic and prognostic groups. In addition to genetic alterations, epigenetic processes play an important role in carcinogenesis, among which histone acetylation/deacetylation is crucial for chromatin modulation structure and transcriptional activity. Histone acetylation is regulate
Publicado em: 2008
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9. Characterization of the RNA Polymerase B Transcricional Factor 3 (btf3) of Trichoderma reesei and the effect of its knockout on gene expression in stress by heat shock / Caracterização do gene do Fator Transcricional 3 da RNA Polimerase B (btf3) de Trichoderma reesei e o efeito de seu nocaute sobre a expressão gênica no estresse por choque térmico
Transcription by RNA polymerase II (RNA polymerase B) and protein synthesis are the most important metabolic processes in eukaryotic cells, and they are involved in the control of gene expression. Trichoderma reesei was used as model of study for the development of this study. This filamentous fungus is a microorganism that has been used by some laboratories
Publicado em: 2007
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10. AnÃlise da regulaÃÃo transcricional de genes de Yersinia em Escherichia coli
Yersiniae possess a type III secretion system, responsible for the translocation of proteins known as Yops, to the interior of the eukaryotic cells of the host. The YopH protein is a tyrosine phosphatase that desphosphorylates signalling molecules and impairs phagocytosis in macrophages. For its efficient secretion it needs the presence of the chaperone SycH
Publicado em: 2005
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11. Caracterização de frações antigênicas de Leishmania braziliensis e avaliação da resposta imune em pacientes com leishmaniose tegumentar. / Characterization of Leishmania braziliensis antigenic fractions and their immune response in patients with tegumentary leishmaniasis.
Leishmania braziliensis is one of the most important causative agents of American tegumentary leishmaniasis (ATL), an endemic disease in Corte de Pedra, Bahia, Brazil, and in almost 88 other subtropical and tropical countries. Many studies about antigen characterization have been done with soluble leishmania antigens (SLA), but few of them involved native or
Publicado em: 2004
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12. Centromere domain organization and histone modifications
Centromere function requires the proper coordination of several subfunctions, such as kinetochore assembly, sister chromatid cohesion, binding of kinetochore microtubules, orientation of sister kinetochores to opposite spindle poles, and their movement towards the spindle poles. Centromere structure appears to be organized in different, separable domains in
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-05