Encapsulation Systems
Mostrando 1-12 de 42 artigos, teses e dissertações.
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1. Preparation and characterization of novel, mucoadhesive ofloxacin nanoparticles for ocular drug delivery
The efficacy of conventional ocular formulations is limited by poor corneal retention and permeation, resulting in low ocular bioavailability. Mucoadhesive chitosan (CS)/ tripolyphosphatesodium (TPP) and chitosan (CS)/ tripolyphosphatesodium (TPP)-alginate (ALG) nanoparticles were investigated for the prolonged topical ophthalmic delivery of ofloxacin. A mod
Braz. J. Pharm. Sci.. Publicado em: 15/08/2019
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2. SYNTHESIS, CHARACTERIZATION AND in vitro CYTOTOXICITY OF Acacia mearnsii PROANTHOCYANIDIN LOADED PLGA MICROPARTICLES
ABSTRACT One of the highlighted areas in the development of new materials is the generation of micro- and nanoparticles as drug carriers which allow the progress in formulations with the ability to release active agents in a controlled way. The proanthocyanidins (PAC) extracted from the bark of the Black Wattle have stood out for their biological activities.
Braz. J. Chem. Eng.. Publicado em: 15/07/2019
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3. Stability of Nanocomposite Edible Films Based on Polysaccharides and Vitamin C from Agroindustrial Residue
The agroindustrial residue from the production of acerola pulp is rich in residual vitamin C. Thus, aiming its extraction and stabilization, this work proposed the nanoparticle (NP) encapsulation via ionic gelation with subsequent preparation of nanocomposites (NC) film based on galactomannan matrix. NP were characterized and their stabilities were evaluated
Mat. Res.. Publicado em: 18/04/2019
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4. Development and Validation of a Stability-Indicating Method for Perillyl Alcohol Incorporated in Poly(lactide-co-glycolide) Nanoparticles and Stress Degradation Studies
Perillyl alcohol has been studied in the treatment of cancer disease. However, its high toxicity is a drawback, which can be overcome by its incorporation in nanostructured systems. The aim of this work was to develop and validate a chromatographic method for determination of perillyl alcohol encapsulation efficiency in a polymeric nanoparticles formulation
J. Braz. Chem. Soc.. Publicado em: 2017-12
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5. Coencapsulation of trans-Dehydrocrotonin and trans-Dehydrocrotonin:hydroxypropyl-β-cyclodextrin into Microparticles
The aim of this study was to develop and characterize poly-ε-caprolactone (PCL) and poly(D,L-lactic-co-glycolic)-acid (PLGA) microparticles containing coencapsulated trans-dehydrocrotonin (t-DCTN) and t-DCTN:hydroxypropyl-β-cyclodextrin inclusion complex (t-DCTN:HP-β-CD), with t-DCTN loaded at concentrations ranging from 11.25 to 45.00 mg. A preformulatio
J. Braz. Chem. Soc.. Publicado em: 2017-08
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6. Development and Characterization of Synthetic Chalcones-Loaded Eudragit RS 100 Microparticles for Oral Delivery
Eudragit® RS100 microspheres of two chalcones were prepared by solvent evaporation technique. A simple and rapid high-performance liquid chromatography (HPLC) method was developed and validated to determine the encapsulation efficiency, drug loading and release profiles of these chalcones in a microparticulate system. The mean EE values for the two chalcone
J. Braz. Chem. Soc.. Publicado em: 2017-06
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7. Floating ability and drug release evaluation of gastroretentive microparticles system containing metronidazole obtained by spray drying
Abstract Gastroretentive floating microparticles were developed and evaluated for the controlled metronidazole delivery for treatment of gastric disease. Floating microparticles, varying in proportions of chitosan and hydroxypropyl methylcellulose or ethylcellulose, were obtained by spray drying. Floating microparticles were characterized by physicochemical
Braz. J. Pharm. Sci.. Publicado em: 20/04/2017
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8. Validation of a Chromatographic Analytical Method for Quantification of Benznidazole Incorporated in Nanostructured Lipid Formulations
Benznidazole (BNZ) has been employed in the treatment of Chagas disease; however, its low water solubility is a drawback, which can be overcome by incorporating BZN within nanostructured systems. The aim of this work was to validate a chromatographic method for determination of BZN incorporated in nanoemulsions (NE) and nanostructured lipid carriers (NLC). T
J. Braz. Chem. Soc.. Publicado em: 2017-02
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9. Pullulan as a stabilizer agent of polymeric nanocapsules for drug delivery
ABSTRACT Polymeric stabilizers have received attention in the preparation of nanostructured systems due to their ability to enhance formulation stability. Considering this, the objective of this work was to prepare poly(ε-caprolactone) nanocapsules using the pullulan as a polymeric stabilizer. The nanocapsules were prepared using the interfacial deposition
Braz. J. Pharm. Sci.. Publicado em: 2016-12
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10. SISTEMAS CARREADORES LIPÍDICOS NANOESTRUTURADOS PARA IVERMECTINA E METOPRENO VISANDO CONTROLE DE PARASITAS
The study of characteristics of nanoscale structures and applications now has great interest of researchers from different areas. In this regard, lipid carriers can improve the bioavailability of drugs and the reduction of possible toxicological effects. Thus, the development of nanostructured systems for the agricultural sector, aimed at combating parasites
Quím. Nova. Publicado em: 2016-11
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11. Preparation and characterization of paclitaxel-loaded PLDLA microspheres
Paclitaxel (Taxol®), is a drug used to treat ovarian, breast, lung and bladder cancer. However, the low solubility of this drug in water is a major limitation in its clinical use. One strategy to overcome this limitation would be to encapsulate paclitaxel in polymeric microspheres that are biocompatible and can be used as drug carriers. The aim of this stud
Mat. Res.. Publicado em: 18/03/2014
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12. Mangiferin: microencapsulation in pectin/chitosan systems, in vitro intestinal metabolism and anticancer activity. / MANGIFERINA: MICROENCAPSULAMENTO EM SISTEMAS PECTINA/QUITOSANA, METABOLISMO INTESTINAL IN VITRO E ATIVIDADE ANTICANCER
MANGIFERIN: MICROENCAPSULATION IN PECTIN/CHITOSAN SYSTEMS, IN VITRO INTESTINAL METABOLISM AND ANTICANCER ACTIVITY This work was performed in four parts: The first part refers to the isolation of pectin from a regional pumpkin in order to be used as matrix for drug encapsulation: Pumpkin (Cucurbita moschata) is an excellent and low cost source of carotenoids,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/08/2012