Development and Characterization of Synthetic Chalcones-Loaded Eudragit RS 100 Microparticles for Oral Delivery

AUTOR(ES)

Kleemann, Cristian R., Santos, Talitha C. dos, Tavares, Luciana C., Pizzolatti, Moacir G., Campos, Angela M. de

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2017-06

RESUMO

Eudragit® RS100 microspheres of two chalcones were prepared by solvent evaporation technique. A simple and rapid high-performance liquid chromatography (HPLC) method was developed and validated to determine the encapsulation efficiency, drug loading and release profiles of these chalcones in a microparticulate system. The mean EE values for the two chalcones-loaded microparticles were 98.8 ± 1.3% and 99.5 ± 0.9%. Scanning electron microscope (SEM) studies showed that one chalcone-loaded microspheres are spherical and smooth appearance whereas the other chalcone-loaded microspheres showed irregular particles and a rough surface. The analysis of the second chalcone by thermogravimetric analysis (TGA) showed a higher thermal stability compared to the first chalcone. Drug release profiles were determined at pH 7.4 phosphate buffered saline (100 mmol L-1) with sodium lauryl sulfate (0.5%). The systems prepared with Eudragit® showed 78 and 95% of the two chalcones were released after 24 hours. The experimental results indicated that the prepared polymeric microspheres may be useful for potential applications.

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