Early Alzheimer Disease
Mostrando 1-12 de 154 artigos, teses e dissertações.
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1. Evaluation of 10-minute post-injection 11C-PiB PET and its correlation with 18F-FDG PET in older adults who are cognitively healthy, mildly impaired, or with probable Alzheimer’s disease
Objective: Positron emission tomography (PET) allows in vivo evaluation of molecular targets in neurodegenerative diseases, such as Alzheimer’s disease. Mild cognitive impairment is an intermediate stage between normal cognition and Alzheimer-type dementia. In vivo fibrillar amyloid-beta can be detected in PET using [11C]-labeled Pittsburgh compound B (11C
Brazilian Journal of Psychiatry. Publicado em: 2022
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2. Early diagnosis and treatment of Alzheimer’s disease: new definitions and challenges
The prevalence of Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is expected to more than double by 2050. Studies on the pathophysiology of AD have been changing our understanding of this disorder and setting a new scenario for drug development and other therapies. Concepts like the “amyloid cascade” and the “continuum of AD,”
Braz. J. Psychiatry. Publicado em: 2020-08
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3. Posturographic analysis of older adults without dementia and patients with Alzheimer’s disease: A cross-sectional study
RESUMO. Ferramentas clínicas adicionais devem ser investigadas para facilitar e auxiliar o diagnóstico prévio do declínio cognitivo. O controle postural piora com o envelhecimento e este fato pode estar relacionado com o comprometimento cognitivo patológico. Objetivo: comparar o equilíbrio de adultos idosos sem demência no grupo controle (GC) e com d
Dement. neuropsychol.. Publicado em: 18/06/2019
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4. Combined association of Presenilin-1 and Apolipoprotein E polymorphisms with maternal meiosis II error in Down syndrome births
Abstract Alzheimer's disease and Down syndrome often exhibit close association and predictively share common genetic risk-factors. Presenilin-1 (PSEN-1) and Apolipoprotein E (APOE) genes are associated with early and late onset of Alzheimer's disease, respectively. Presenilin −1 is involved in faithful chromosomal segregation. A higher frequency of the APO
Genet. Mol. Biol.. Publicado em: 31/07/2017
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5. Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders
The impact of neurological disorders in society is growing with alarming estimations for an incidence increase in the next decades. These disorders are generally chronic and can affect individuals early during productive life, imposing real limitations on the performance of their social roles. Patients can have their independence, autonomy, freedom, self-ima
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 29/09/2015
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6. Mild cognitive impairment (part 2): biological markers for diagnosis and prediction of dementia in Alzheimer's disease
Objective: To present a critical review of publications reporting on the rationale and clinical implications of the use of biomarkers for the early diagnosis of Alzheimer's disease (AD). Methods: We conducted a systematic search of the PubMed and Web of Science electronic databases, limited to articles published in English between 1999 and 2012, and based
Rev. Bras. Psiquiatr.. Publicado em: 2013-09
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7. Associação dos níveis de BDNF (brain derived neurotrophic factor) no comprometimento cognitivo leve e na doença de Alzheimer
Background: It has been suggested that there is an association between brain-derived neurotrophic factor (BDNF) and the neuropathology of Alzheimer¿s disease (AD). However, little is known about the role of BDNF in subjects with mild cognitive impairment (MCI). In the present study, we investigated BDNF serum levels in healthy elderly, amnestic MCI, and mil
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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8. Alterações metabólicas cerebrais associadas aos fatores de risco cardiovascular: um estudo de tomografia por emissão de pósitron (PET) / Abnormalities on brain metabolism associated to cardiovascular risk factors: a positron emission tomography (PET) study
INTRODUCTION: Cardiovascular risk factors (CVRF) are known to affect cerebral blood flow, possibly contributing to cognitive decline and to the emergence of Alzheimers disease (AD), the commonest form of dementia. Positron emission tomography (PET) with 18-fluoro-2-deoxyglucose (18FFDG) has been widely used to demonstrate specific patterns of reduced brain g
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/12/2011
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9. Funções Visuoespaciais na Doença de Alzheimer de Intensidade Leve Uso da Bateria VOSP (Visual Object and Space Perception) em nosso meio / Visuospatial function in early Alzheimers Disease The use of the VOSP (Visual Object and Space Perception) battery in a brazilian sample
A Doença de Alzheimer é a causa mais frequente de demência. Os sintomas clínicos da doença se iniciam com um comprometimento da memória e da função executiva, gradativamente há um envolvimento de outras funções como a linguagem, conhecimento semântico, pensamento abstrato, atenção e habilidades visuoespaciais. A função visuoespacial consiste
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/11/2011
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10. Interpretação de provérbios por sujeitos com Doença de Alzheimer em fase inicial / Interpretation of proverbs by subjects with Alzheimer s disease at an early stage
Esta pesquisa teve como objetivo estudar os processos de significação na interpretação de provérbios por sujeitos com provável doença de Alzheimer (DA) leve. Participaram da pesquisa qualitativa 10 sujeitos com idade igual ou superior a 60 anos com DA de ambos os sexos, que foram selecionados no Ambulatório de Psiquiatria Geriátrica do HC da UNICAMP
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/08/2011
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11. Alterações sistêmicas e comportamentais de interesse odontológico em pacientes com síndrome de Down / Dental implications of systemic and behavior alterations in Downs syndrome patients
Downs syndrome (DS) is the most common genetic disorder and it is caused by the trissomy of 21 chromosome. It is characterized by mental retardation, physical alterations and several systemic co morbidities. The aim of this study was to evaluate behavior and systemic alterations with dental implications in DS patients and discuss the dental management of the
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2011
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12. Neuropsychological and neurobiological markers of the preclinical stage of Alzheimer's disease
Dementia, especially Alzheimer's disease, has a high prevalence in the elderly population. Therefore, identifying individuals who are at a high risk for early diagnosis is crucial to allow both pharmacological and behavioral therapeutic interventions, which in some cases can delay the progression of dementia. This paper describes neuropsychological and neuro
Psychology & Neuroscience. Publicado em: 2011