Drug Plasma Monitoring
Mostrando 25-36 de 66 artigos, teses e dissertações.
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25. Avaliação técnica SPME/LC na análise de antidepressivos em amostra de plasma para fins de monitorização terapêutica / Evaluation of SPME/LC technique in the antidepressants analysis in plasma sample for ends of therapeutic monitoring
As recentes técnicas miniaturizadas de preparo de amostra, microextração em fase sólida (SPME) e in tube SPME, apresentam uma série de vantagens em relação aos métodos clássicos de extração (extração líquido-líquido e extração em fase sólida), tais como: não requer instrumentação analítica sofisticada, utilização de pequenas quantidad
Publicado em: 2007
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26. Determination of chlorpropamide in plasma, using high-performance liquid chromatography coupled to tandem mass spectrometry (LC/MS/MS) and their application in a study of bioequivalence / Determinação de clorpropamida em plasma empregando empregando cromatografia liquida de alta eficiencia acoplada a espectrometria de massa sequencial (LC/MS/MS) e sua aplicação em um estudo de bioequivalencia
The relative bioavailability between two formulations of chlorpropamide was assessed on the dosage form tablet 250 mg, in healthy volunteers of both sexes. The study was conducted using an open, randomized, two-period crossover design with the 3-week washout interval. Thirty-six subjects were selected. The blood samples were collected at the time prior to do
Publicado em: 2007
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27. Metho of quantification of nucleotides by HPLC-MS/MS and evaluation of the activity of sildenafil analoges in phosphodiesterase / Metodo de quantificação de nucleotideos por HPLC-MS/MS e avaliação da atividade de analogos de sildenafil sobre fosfodiesterase
In the present work a new method for the dosage of the activity of phosphodiesterase was standardized in vitro, for HPLC-MS/MS. This new method obtained to present exactness, precision, sensitivity, and rapidity in the analyses; monitoring the nucleotides (AMP, GMP, cAMP and cGMP). The development of new drug derived from an archetype points with respect to
Publicado em: 2007
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28. Uso da vancomicina nas infecções por Staphylococcus aureuse epidermides em pacientes queimados: monitoramento das concentrações plasmáticas após infusão intermitente / Use of vancomycin in staphylococcus aureus and epidermides infection on burns patients: therapeutic drug monitoring in plasma after intermitent infusion
O paciente grande queimado está entre os de maior risco de contrair infecção hospitalar, sendo que, aproximadamente 80% dos óbitos nestes pacientes são decorrentes de infecção. Devido à prevalência de S. aureus meticilina resistente (MRSA) nas unidades de queimados prescreve-se a vancomicina como fármaco de 1ª linha. Entretanto como a farmacociné
Publicado em: 2007
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29. DESENVOLVIMENTO E VALIDAÇÃO DE METODOLOGIAS PARA AVALIAÇÃO DE ETORICOXIBE POR CROMATOGRAFIA LÍQUIDA E ESPECTROMETRIA DE MASSAS / DEVELOPMENT AND VALIDATION OF METHODOLOGIES FOR THE EVALUATION OF ETORICOXIB BY LIQUID CHROMATOGRAPHY AND MASS SPECTROMETRY
Etoricoxib is a non-steroidal anti-inflammatory drug, from the coxibs group, that represents a second-generation of COX-2 inhibitors, used for the treatment of arthritis and pain. The methodologies for the evaluation of etoricoxib in pharmaceutical products and plasma were developed and validated in the present work. The reversed-phase liquid chromatography
Publicado em: 2006
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30. Estudo de bioequivalencia entre duas formulações de azitromicina utilizando a cromatografia liquida de alta eficiencia acoplada ao espectrometro de massa (LC-MS-MS)
Objective: To assess the bioequivalence of two azithromycin tablet formulations (Azitromicina 500 mg tablet fromEMS Indústria Farmacêutica, Brazil as test formulation and Zitromax@500 mg tablet from Laboratórios Pfizer, Brazil as reference formulation) in 25 healthy volunteers of both sexes. The study was conducted using an open, randomized two-period cro
Publicado em: 2005
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31. A simple HPLC-fluorescence method for the measurement of R,S-sotalol in the plasma of patients with life-threatening cardiac arrhythmias
R,S-sotalol, a ß-blocker drug with class III antiarrhythmic properties, is prescribed to patients with ventricular, atrial and supraventricular arrhythmias. A simple and sensitive method based on HPLC-fluorescence is described for the quantification of R,S-sotalol racemate in 500 µl of plasma. R,S-sotalol and its internal standard (atenolol) were eluted af
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-02
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32. Estudo de bioequivalencia de duas formulações comerciais de comprimidos de sertralina em voluntarios sadios
Objective: to compare the bioavailability of 2 sertraline tablets formulations (Tolrest@ from Laboratórios Biosintética, and Zoloft@ from Laboratórios Pfizer, Brazil) in 24 healthy volunteers of both sexes (12 male and 12 female) who received a single 50 mg dose of each sertraline formulation. Material and methods: the study was conducted open with random
Publicado em: 1999
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33. Influence of hemodialysis on plasma concentration-time profiles of mefloquine in two patients with end-stage renal disease: a prophylactic drug monitoring study.
Prophylactic drug monitoring of mefloquine and its carboxylic acid metabolite were studied in two patients with end-stage renal disease undergoing long-term hemodialysis treatment. The patients, short-term travellers to areas where malaria is endemic, took 250 mg of mefloquine (Lariam) once weekly for 2 weeks before and during their 3-week stay abroad and fo
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34. Elevation of plasma phenytoin by viloxazine in epileptic patients: a clinically significant drug interaction.
The effect of viloxazine (150-300 mg daily for 21 days) on plasma phenytoin levels at steady state was examined in 10 epileptic patients stabilised on a fixed phenytoin dosage. After starting viloxazine treatment, plasma phenytoin concentrations increased by 37% on average (range 7-94%) from a mean value of 18.8 micrograms/ml at baseline to a mean value of 2
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35. Therapeutic Drug Monitoring of Posaconazole: a Monocentric Study with 54 Adults▿
Posaconazole is a potent broad-spectrum triazole antifungal. Little is known about the prevalence and risk factors for low plasma posaconazole concentrations (PPCs). We retrospectively reviewed all adult patients whose PPCs were measured after at least 5 days of treatment between April 2006 and July 2008 at the Hôpital Necker Enfants Malades. A low PPC was
American Society for Microbiology (ASM).
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36. Diabetogenic effect of cyclosporin.
A young woman given a renal allograft for polycystic kidney disease developed insulin dependent diabetes mellitus 25 days after transplantation. There was no family history of diabetes, plasma glucose concentrations had been normal at presentation and on five subsequent occasions, and at no time were islet cell antibodies detectable. Plasma C peptide concent