Drug Plasma Monitoring
Mostrando 13-24 de 66 artigos, teses e dissertações.
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13. Fluconazole plasma concentration measurement by liquid chromatography for drug monitoring of burn patients
Clinics. Publicado em: 2010
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14. Desenvolvimento das barras imunosorventes de agitação e avaliação das técnicas extração sortiva em barra de agitação, microextração em sorvente empacotado e cromatografia líquida para análise de antidepressivos em amostras de plasma / Development of immunosorbent stir bars and evaluation of stir bar sorptive extraction, microextraction by packed sorbent and liquid chromatography for the analysis of antidepressants in plasma samples
In this work, polyclonal and monoclonal anti-fluoxetine antibodies were developed in rabbits and mice by immunization with fluoxetine-bovine albumin conjugate, respectively. The developed antibodies were characterized on the basis of the specificity against the drug by ELISA (enzyme linked immunosorbent assay) and, subsequently they were purified by labmade
Publicado em: 2010
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15. Development and validation of methodology for HPLC-PDA for therapeutic monitoring of plasma levels of zidovudine and efavirenz / Desenvolvimento e validação de metodologia por HPLC-PDA para monitoração terapêutica dos níveis plasmáticos de zidovudina e efavirenz
The therapeutic drug monitoring is an important tool to predict the therapeutic efficacy and possible toxicity of antirretroviral agents used to treat infection by human immunodeficiency virus (HIV). The goals of this study was to develop and validate a method of analysis and extraction to quantify the antirretrovirals efavirenz and zidovudine in human plasm
Publicado em: 2009
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16. Monitorização terapêutica da olanzapina em pacientes esquizofrênicos / Therapeutic monitoring of olanzapina in schizophrenic patients
The olanzapine is an atypical antipsychotic drug used to treat schizophrenia. How adverse effects related to its use, are obesity, hyperlipidemia, diabetes mellitus type II and hypertension, may result in the development of metabolic syndrome. This study aims to carry out monitoring therapy in patients in treatment with olanzapine, establishing a possible co
Publicado em: 2009
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17. Biodisponibilidade comparativa de duas formulações de losartan em voluntarios humanos sadios apos administração de dose unica / Comparative bioavailability of two losartan formulations in healthy human volunteers after a single dose administration
This dissertation focus in the evaluation of the bioavailability of two formulations of potassium losartan immediate release tablet 50mg (Losartan from Laboratórios Cristália Ltd., Brazil, as a test formulation and Cozaar® from Merck Sharp &Dohme Farmacêutica Ltd., Brazil as a reference formulation). The bioequivalence study was conducted using an open,
Publicado em: 2009
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18. Motorização terapêutica do metotrexato sob altas doses, em pacientes portadores de leucemia linfoblástica aguda / Therapeutical drug monitoring of methotrexate under high dosages in pacients with acute lymphoblastic leukemia
O metotrexato (MTX) é um fármaco de elevada toxicidade utilizado em doses geralmente elevadas, no tratamento de neoplasias. Concentrações terapêuticas preservam a eficácia, porém valores acima elevam o risco de intoxicação. Assim o presente trabalho objetivou desenvolver e validar uma técnica analítica em HPLCPDA para dosagem do metotrexato em pla
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/09/2008
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19. Molecular characterisation of newly identified HIV-1 infections in Curitiba, Brazil: preponderance of clade C among males with recent infections
As in many areas of Brazil, the AIDS epidemic in Curitiba is relatively stable, but surveillance is important to support public policy. The molecular characteristics of HIV may be instrumental for monitoring epidemic trends. We evaluated plasma HIV-1 RNA (n = 37) from 38 cases presenting with positive serology, who were among 820 consenting volunteers visiti
Memórias do Instituto Oswaldo Cruz. Publicado em: 2008-12
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20. Prevalence of resistance-associated mutations in Human Immunodeficiency Virus type 1-positive individuals failing HAART in Rio de Janeiro, Brazil
We investigated the occurrence of HIV-1 antiretroviral resistance in individuals failing to respond to highly active antiretroviral therapy (HAART) attended by RENAGENO from 2001-2004. One hundred and seventeen patients were selected for this study; their plasma viral RNA was extracted and the PR and RT genes sequenced to examine subtype, genetic polymorphis
Brazilian Journal of Infectious Diseases. Publicado em: 2008-10
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21. Determining plasma morphine levels using GC-MS after solid phase extraction to monitor drug levels in the postoperative period
OBJECTIVE: To implement a selective and sensitive analytical method to quantify morphine in small volumes of plasma by gas-liquid chromatography-mass spectrometry (GC-MS), aimed at post-operatively monitoring the drug. METHOD: A gas-liquid chromatographic method with mass detection has been developed to determine morphine concentration in plasma after solid
Clinics. Publicado em: 2008
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22. Estudo da estabilidade e do perfil de liberação de comprimidos de maleato de enalapril e determinação da concentração plasmática em pacientes
The stability of a pharmaceutical formulation can be a major factor in assuring the quality of a drug product and, as a consequence, the efficacy of the treatment. Enalapril is an anti-hypertensive pro-drug that, after being absorbed, is hydrolised into enalaprilat, an agent responsible for blocking the conversion of angiotensin I into angiotensin II. Stabil
Publicado em: 2008
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23. Motorização terapêutica do metotrexato sob altas doses, em pacientes portadores de leucemia linfoblástica aguda / Therapeutical drug monitoring of methotrexate under high dosages in pacients with acute lymphoblastic leukemia
O metotrexato (MTX) é um fármaco de elevada toxicidade utilizado em doses geralmente elevadas, no tratamento de neoplasias. Concentrações terapêuticas preservam a eficácia, porém valores acima elevam o risco de intoxicação. Assim o presente trabalho objetivou desenvolver e validar uma técnica analítica em HPLCPDA para dosagem do metotrexato em pla
Publicado em: 2008
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24. Cromatografia líquida multidimensional e espectrometria de massas em tandem para análise direta de fármacos em fluidos biológicos: da escala convencional à miniaturizada / Multidimensional liquid chromatography and tandem mass spectrometry for the direct analysis of grugs in biofluids: from the conventional to the miniaturized scale
Analysis of drugs and other related molecules in biofluids is essential in the pharmaceutical field. Nowadays, the development of innovative solutions in analytical chemistry has been pushed by the needs for speed and more complex analysis. Lately, multidimensional liquid chromatography using column switching for direct injection of biofluids has gained atte
Publicado em: 2007