Dna Cleavage
Mostrando 13-24 de 3515 artigos, teses e dissertações.
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13. Investigação da reação de Morita-Baylis-Hillman em reator de micro-ondas usando aldeídos aromáticos e isatina como eletrófilos: avaliação da atividade citotóxica em linhagem de células de leucemia promielocítica humanas (HL-60). / Investigation of Morita-Baylis-Hillman Reaction on Microwave Reactor using Aromatic Aldehydes and Isatin as Eletrophiles: Evaluation of Cytotoxic Activity in cell line human promyelocytic leukemia (HL-60).
In this work, we describe the investigation of the Morita-Baylis-Hillman reaction in microwave reactor, under closed vessel conditions to prepare 40 adducts, six novel, using 30 aromatic aldehydes and isatin as electrophiles and acrylonitrile (62a) , methyl acrylate (2), hydroxyethyl acrylate (62b), 2,2-dimethyl-1 ,3-dioxalyl acrylate (62c) and 2,3-dihydroxy
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/11/2012
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14. Avaliação do valor de predição de clivagem química de radicais hidroxila em regiões promotoras de genes ligados ao desenvolvimento craniofacial / Evaluation of predictive value for chemical cleavage of hydroxy radicals in the promoter regions of genes related to craniofacial developmentl
The initiation of the gene transcription is a very complex phenomenon, probably the principal stage where the control of the gene expression takes place. In general terms the transcription takes place with the connection of proteins called "transcription factors" with specific sequences of the DNA, called of regions or sequences "cis ". The interaction DNA -
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/02/2012
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15. CARACTERIZAÇÃO MOLECULAR DOS COMPONENTES DO SISTEMA ANGIOTENSINA-(1-7) DURANTE A DIVERGÊNCIA FOLICULAR E EXPRESSÃO DE GENES DE REPARO DA FITA DUPLA DE DNA EM EMBRIÕES BOVINOS / MOLECULAR CHARACTERIZATION OF THE ANGIOTENSIN-(1-7) SYSTEM COMPONENTS DURING FOLLICULAR DEVIATION AND EXPRESSION OF DNA DOUBLE-STRANDED REPAIR GENES IN BOVINE EMBRYOS
The first study characterized the expression of MAS receptor and key enzymes for Ang-(1-7) production, such as, ACE2, NEP and PEP during follicular development. Furthermore, the regulation of local Ang1-7 system was evaluated after the intrafollicular injection of fulvestrant (an estradiolreceptor inhibitor) in the dominant follicle. Cows were ovariectomized
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/02/2012
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16. Avaliação do swim-up e do gradiente descontinuo de densidade na pré-seleção do sexo de espermatozoides na produção de embriões bovinos
The purpose of this work was to associate the modified swim-up method with centrifugation in density gradient for the separation of X-bearing spermatozoa. Sperm viability and integrity were evaluated through the Trypan Blue/Giemsa staining method. Quality control of centrifuged spermatozoa was performed in in vitro produced embryos. The results were validate
Arquivo Brasileiro de Medicina Veterinária e Zootecnia. Publicado em: 2012-06
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17. Genotype analysis of the human endostatin variant p.D104N in benign and malignant adrenocortical tumors
OBJECTIVE: Endostatin is a potent endogenous inhibitor of angiogenesis. It is derived from the proteolytic cleavage of collagen XVIII, which is encoded by the COL18A1 gene. A polymorphic COL18A1 allele encoding the functional polymorphism p.D104N impairs the activity of endostatin, resulting in a decreased ability to inhibit angiogenesis. This polymorphism h
Clinics. Publicado em: 2012
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18. Atividade antioxidante de extratos e compostos isolados de Eugenia umbelliflora e Rapanea ferrugínea / ANTIOXIDANT ACTIVITY OF ISOLATED COMPOUNDS AND EXTRACTS OF Eugenia umbelliflora and Rapanea ferruginea
Eugenia umbeliflora is popularly known as baguaçu, guapê or guaramirim in Portuguese and Brazilian Cherry in English. This species is used in popular medicine to treat diseases such as arthritis, rheumatism and diabetes, although there have been few biological studies to verify the effectiveness of these extracts. Rapanea ferruginea is popularly known as c
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/09/2011
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19. SYNTHESIS AND CHARACTERIZATION OF BINUCLEATING LIGANDS DERIVED FROM THE ISONIAZID AND THEIR DINUCLEAR COPPER(II) COMPLEXES / SÍNTESE E CARACTERIZAÇÃO DE LIGANTES BINUCLEANTES DERIVADOS DA ISONIAZIDA E SEUS COMPLEXOS BINUCLEARES DE COBRE (II)
Considering the limitations and undesirable side effects observed in cancer therapy with platinum derivatives, many efforts have been made with the aim of obtaining new drugs more effective and less toxic, able to promote the hydrolytic cleavage or oxidative DNA chain other subcellular structures critical. Until now, some copper complexes have been developed
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2011
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20. In vitro evaluation of triazenes: DNA cleavage, antibacterial activity and cytotoxicity against acute myeloid leukemia cells
As diazoaminas assimétricas 1-(2-clorofenil)-3-(4-carboxifenil)triazeno (1), 1-(2-fluorofenil)-3-(4-carboxifenil)triazeno (2) e 1-(2-fluorofenil)-3-(4-amidofenil)triazeno (3) foram avaliadas quanto à capacidade de clivagem do DNA plasmidial pUC18 e pBSKII, atividade antibacteriana e citotoxicidade in vitro frente a células de leucemia mielóide aguda e le
Journal of the Brazilian Chemical Society. Publicado em: 2010-12
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21. Distribution of recombination rates across the chromosome 4 of Arabidopsis thaliana and its association with genomic features / Distribuição de taxas de recombinação ao longo do cromossomo 4 de Arabidopsis thaliana e sua associação com elementos genômicos
Recombination is one of the most important factors in the evolution of genome organization. It provides the links between homologous chromosomes that ensure their proper segregation during the first meiotic division. It is responsible for the creation of novel allele combinations and yields genetic diversity on which evolutionary selection can act. Double-st
Publicado em: 2010
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22. Catalytic promiscuity: catecholase-like activity and hydrolytic DNA cleavage promoted by a mixed-valence FeIII FeII complex
Os estudos sobre enzimas têm mostrado que existe uma relação clara entre a evolução enzimática e a propriedade de promiscuidade catalítica que elas podem apresentar. Com isto, o desenvolvimento de sistemas biomiméticos capazes de atuar de modo promíscuo, de forma similar a algumas enzimas, mostrou-se um novo desafio para os químicos bioinorgânicos
Journal of the Brazilian Chemical Society. Publicado em: 2010
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23. Evaluation of beta-carotene microencapsulated antimutagenic activity in cells of rats treated with antitumor doxorubicin using micronucleus test and comet assay / Avaliação da atividade antimutagênica do beta-caroteno microencapsulado em células de ratos tratados com o antitumoral doxorrubicina empregando os ensaios de micronúcleo e cometa
Colorants are commonly used in the food industry. From natural or synthetic origin, these colorants are used in food production in order to recompense the loss of color during manufacturing and stowage processes, guarantee color uniformity and also attribute color to those colorless ones. Among natural pigments, beta-carotene (BC) has been one of the most ad
Publicado em: 2010
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24. Association of eosinophil cationic protein gene polymorphism with tumor-associated tissue eosinophilia in oral squamous cell carcinomas / Associação do polimorfismo do gene da proteína catiônica eosinofílica com a eosinofilia tecidual associada aos tumores em carcinomas espinocelulares de boca
Eosinophil cationic protein (ECP), found in secretory granules of human eosinophils, presents cytotoxic activity, particularly against cancer cells. The specific functional role of eosinophils in solid malignant tumors remains unclear. The aim of this study was to investigate the prevalence of the ECP-gene polymorphism 434(G>C) in oral squamous cell carcinom
Publicado em: 2008