Complement C1q
Mostrando 1-12 de 155 artigos, teses e dissertações.
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1. Resposta à carta ‘‘TyG na predição da resistência à insulina’’
ABSTRACT Castor bean is a very important crop, however, in Brazil it still has relatively low productivity, 0.47 Mg ha-1 as a mean. Besides that the Country has significant castor oil demand and depends on international commerce to complement its production. The solution of these problems goes through the development of genotypes highly productive and adapte
J. Pediatr. (Rio J.). Publicado em: 2020-02
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2. Melanin particles isolated from the fungus Fonsecaea pedrosoi activates the human complement system
BACKGROUND Melanin production has been associated with virulence in various pathogenic fungi, including Fonsecaea pedrosoi, the major etiological agent for chromoblastomycosis, a subcutaneous fungal disease that occurs in South America. OBJECTIVE The aim of this study was to evaluate the effects of acid-basic extracted F. pedrosoi melanin particles and fun
Mem. Inst. Oswaldo Cruz. Publicado em: 25/06/2018
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3. Molecular characterization of the complement C1q, C2 and C4 genes in Brazilian patients with juvenile systemic lupus erythematosus
OBJECTIVE: To perform a molecular characterization of the C1q, C2 and C4 genes in patients with juvenile systemic lupus erythematosus. METHODS: Patient 1 (P1) had undetectable C1q, patient 2 (P2) and patient 3 (P3) had decreased C2 and patient 4 (P4) had decreased C4 levels. All exons and non-coding regions of the C1q and C2 genes were sequenced. Mononuclea
Clinics. Publicado em: 2015-03
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4. Investigação de imunodeficiências primárias em pacientes com lúpus eritematoso sistêmico juvenil / Primary immunodeficiencies in juvenile systemic lupus erythematosus patients
Objetivos: Os objetivos deste estudo foram: avaliar a frequência de imunodeficiências primárias de anticorpos e Complemento em pacientes com lupus eritematoso sistêmico juvenil (LESJ); avaliar possíveis associações entre a presença de imunodeficiência primária (IDP) e dados demográficos, ocorrência de infecções, manifestações clínicas, ativi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/05/2011
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5. Níveis séricos e polimorfismos gênicos da Lectina Ligadora de Manose (MBL) e da Serino Protease Associada à MBP (MASP)-2 em uma amostra da população brasileira / Mannose-binding lectin (MBL) and MBL Associated Serine Protease (MASP)-2 serum levels and genetic polymorphisms in a Brazilian population sample
A Lectina Ligadora de Manose (MBL) é uma proteína que reconhece carboidratos na superfície microbiana levando à ativação do sistema complemento. Este processo é mediado por Serino Proteases tal como a MASP-2. O complexo MBL/MASP-2 é responsável pela formação da C3 convertase C4bC2b. Os níveis séricos de MBL e a MASP-2 (genes MBL2 e MASP-2, respe
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/04/2011
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6. The role of apoptosis proteins and complement components in the etiopathogenesis of systemic lupus erythematosus
Systemic lupus erythematosus is a prototypical autoimmune disease characterized by the deregulation of T and B cells, tissue infiltration by mononuclear cells, tissue damage and the production of autoantibodies. There is a consensus that accelerated apoptosis of circulating lymphocytes and/or impaired clearance of apoptotic bodies may increase the amount of
Clinics. Publicado em: 2010
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7. Mecanismos inflamatórios e imunológicos na síndrome de Down / Inflammatory and immunological mechanism in Downs syndrome
In recent years there has been an increase in life expectancy of individuals with Down´s syndrome (DS), with death causes differ from the general population. Some studies have shown that the immune response differs throughout life with changes related to aging. The RCAN1 gene (regulator of calcineurin type 1), located in the q22.12 region of chromosome 21 i
Publicado em: 2009
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8. Influence of point variants of pattern recognition receptors in the susceptibility to human malaria / Influência de variantes de receptores de reconhecimento padrão na suscetibilidade à malária
Malaria is one of the major causes of disease and death worldwide, mainly of children. It is also the strongest known force for evolutionary selection in the recent history of the human genome. Besides environmental and parasite factors, host genetic factors play a major role in determining both susceptibility to malaria and the course of infection. Innate i
Publicado em: 2008
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9. Isolation and biochemical characterization of components from Tityus serrulatus venom with action on the complement system / Isolamento e caracterização bioquímica de componentes do veneno de Tityus serrulatuscom ação sobre o sistema complemento
Este trabalho relata o isolamento e caracterização bioquímica parcial de componentes do veneno de Tityus serrulatus (VTs) com ação sobre o sistema complemento (SC). O procedimento de purificação envolveu uma cromatografia de troca iônica do VTs em CM-celulose-52, em pH 7,8 e doze frações foram obtidas, denominadas de I a XIII. A fração I, que apr
Publicado em: 2007
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10. Caracterização da calreticulina do Rhipicephalus (Boophilus) microplus (Acari:ixodidae) na interação parasita hospedeiro
O carrapato Riphicephalus (Boophilus) microplus é um ectoparasito hematófago que infesta os rebanhos bovinos de regiões tropicais e subtropicais, causando grandes prejuízos à pecuária. O principal método de controle baseia-se nos acaricidas. No entanto, o uso de vacinas tem sido estudado como um método de controle alternativo. A calreticulina (CRT) �
Publicado em: 2007
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11. Caracterização molecular da deficiencia de proteina S
Human protein S is a plasmatic vitamin-K dependent glicoprotein that acts as a non-enzimatic cofactor of activated protein C in the protein C anticoagulant pathway. In addition to this protein S has an independent role that activated protein C, which is to inactivate factors Va and Xa. The plasmatic concentration of protein S is regulated by a C4b binding pr
Publicado em: 1998
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12. Antibody-independent binding of complement component C1q by Legionella pneumophila.
Incubation of Legionella pneumophila Philadelphia 1 in normal human serum depleted of either classical-pathway component C1q or alternative-pathway component factor B resulted in activation of the complement system. Experiments focused on the role of the classical pathway in complement activation revealed that legionellae bound C1q independently of antibody.