Chemical Terminal
Mostrando 13-24 de 610 artigos, teses e dissertações.
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13. Estudo do metabolismo, quimica e farmacocinetica do principal metabolito da diidroergocristina / Metabolic, chemical and pharmacokinetics of the main diidroergocristine metabolite
Dihydroergocristine (DHEC) is a semi-synthetic drug mainly used for migraine and studied in age-related cognitive impairment. In this study, its major metabolite 8´-hydroxy-dihydroergocristine (8´-OH-DHEC) was produced in incubates of a bovine liver preparation using dihydroergocristine mesylate (DHECM) as substrate. An evaluation of the best enzymatic pre
Publicado em: 2009
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14. Efeitos farmacologicos e morfologicos do polietilenoglicol (PEG 400) em preparações neuromusculares / The influence of polyethylene glycol 400 (PEG) on the neuromuscular junction
Polyethyleneglycol has been widely used in several areas such as cosmetic, odontology and pharmaceutical (even as drugs carrier) due to its chemical properties. Thus, it is considered a bioactive molecule being its internal consumption approved by the Food and Drug Administration (FDA). The aim of this study was to analyze the pharmacological effects of PEG
Publicado em: 2009
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15. Biochemical and biophysical studies of metalloproteinases/disintegrins from snake venom / Estudos bioquímicos e biofísicos de metaloproteinases/desintegrinas de venenos de serpentes
Metalloproteinases/disintegrin (MD) isolated from snake venom are potent inhibitors of platelet aggregation and cell adhesion, processes involved in illnesses as cancer and thrombosis. MD belong to the PIII class of the metalloproteinase/disintegrin gene family and they are constituted by three domains: the catalytic domain, metalloprotease; disintegrin-like
Publicado em: 2008
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16. Macozoobenthic community structure in the region influenced by Almirante Barroso Terminal (TEBAR) in the São Sebastião Channel (SP, Brasil) / Estrutura da comunidade macrozoobentônica na região de influência do Terminal Almirante Barroso (TEBAR) no Canal de São Sebastião (SP, Brasil)
A study of benthic macrofauna was carried out along the São Sebastião Channel (SSC) during summer and winter of 2005. Sediment samples were undertaken (van Veen grab 0.03 m2) to chemical and biological analysis, in an area influenced by anthropogenic activities. The stations nearby the Terminal Almirante Barroso (TEBAR) oil terminal, Araçá sewage system
Publicado em: 2007
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17. A model for the RecA protein of Mycoplasma synoviae
In this work, we predict a structural model for the RecA protein from M. synoviae (MsRecA) by theoretical homology modeling and evaluate the occurrence of polymorphisms in this protein within several isolates of this species. The structural model suggested for MsRecA conserves the main domains present in MtRecA and EcRecA. The L1 and L2 regions showed six an
Genetics and Molecular Biology. Publicado em: 2007
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18. Purificação e caracterização de uma nova fosfolipase A2 ácida da peçonha de Bothrops pauloensis
Phospholipases A2 (PLA2) is small enzymes that present molecular mass around 15kDa and are found in a variety of biological and cellular fluids as fluid sinovial, macrophages, platelet, pancreatic tissue, among others. The present work describes the purification and chemical, biological and enzymatic characterization of an acidic phospholipase A2 of Bothrops
Publicado em: 2006
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19. PurificaÃÃo e caracterizaÃÃo de uma nova fosfolipase A2 Ãcida da peÃonha de Bothrops pauloensis
Phospholipases A2 (PLA2) is small enzymes that present molecular mass around 15kDa and are found in a variety of biological and cellular fluids as fluid sinovial, macrophages, platelet, pancreatic tissue, among others. The present work describes the purification and chemical, biological and enzymatic characterization of an acidic phospholipase A2 of Bothrops
Publicado em: 2006
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20. Purification and investigation of the physical-chemical protease inhibitors properties from acacia plumosa lowe seeds. / Purificação e investigação de propriedades físico-químicas de inibidores de proteases extraídos das sementes de aácia plumosa Lowe.
Seeds of plants belonging to Leguminosae family are rich sources of protease inhibitors. The Acacia genus is one of the most important members of this group. In this work, novel protease inhibitors from Acacia plumose Lowe seeds have been described. From the saline extract of mature seeds, the inhibitors were purified by size exclusion chromatography on Supe
Publicado em: 2006
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21. The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review
The modern approach to the development of new chemical entities against complex diseases, especially the neglected endemic diseases such as tuberculosis and malaria, is based on the use of defined molecular targets. Among the advantages, this approach allows (i) the search and identification of lead compounds with defined molecular mechanisms against a defin
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-10
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22. Confinamento lateral de portadores e fotons e o comportamento espectral de laser em tres terminais
The availability of semiconductor quantum-well structures increased the interest in the development of systems for optical computing and optical interconnection using semiconductor lasers as the basic component in optoelectronic integrated circuits. Therefore, there is a great interest in searching for novel materials and structures as well as fabrication te
Publicado em: 2001
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23. Participação do oxido nitrico no desenvolvimento da encefalomielite alergica experimental em ratos
Nitric oxide (NO) is a free radical endogenously synthetised by oxidation of one of the guanidinum nitrogen atoms of the aminoacid L-arginine by molecular oxygen. This biosynthesis is catalised by a family of enzimes generically known as nitric oxide synthases (NOS), which can be inhibited by structural analogs of L-arginine having substituent groups at the
Publicado em: 2001
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24. Miotoxinas PLA2 "like" de Bothrops pirajai : caracterização molecular e funcional
The genus Bothrops comprises severaI species, which are widely distributed in South and North America. Among the bioactive proteins from Bothrops venoms, the phospholipase A2(PLA2,E.C.3.1.14) and PLA2-likemyotoxin are outstanding as their major components. Phospholipase A2Sare calcium-dependent enzymes which hydrolyze the 2 ester bonds of 1,2 diacyl-3sn phos
Publicado em: 2000