Casr
Mostrando 1-12 de 27 artigos, teses e dissertações.
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1. Nova mutação no gene CASR em uma família com hipercalcemia hipocalciúrica familiar (HHF) e hiperparatireoidismo neonatal grave (HPTNG)
Mutações inativadoras no gene do sensor do cálcio (CASR) podem causar hipercalcemia hipocalciúrica familiar (HHF) ou hiperparatireoidismo neonatal grave (HPTNSG). A HPTNS representa a forma mais grave da HHF cursando com risco de vida. O objetivo deste estudo foi identificar e caracterizar uma mutação no gene CASR de uma criança do sexo feminino levad
Arquivos Brasileiros de Endocrinologia & Metabologia. Publicado em: 2011-02
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2. Avaliação dos polimorfismos do receptor de vitamina D (VDR) e do receptor sensor de cálcio (CaSR) em pacientes portadores de litíase renal
Alguns estudos identificaram uma associação entre nefrolitíase e os polimorfismos do Receptor de Vitamina D (VDR) ou do Receptor Sensor de Cálcio (CaSR). O objetivo deste estudo foi avaliar uma possível associação destes polimorfismos com a excreção de cálcio urinário (CaU) em pacientes litiásicos. O polimorfismo do VDR, detectado através da dig
Publicado em: 2009
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3. INVESTIGANDO O ESPORTE COMO MEIO DE INCLUSÃO SOCIAL DE CRIANÇAS E ADOLESCENTES EM SITUAÇÕES DE RISCO
This study aimed to investigate whether the sport provided by Children and dolescents in Situations of Risk (CASR) promote social inclusion. We, in a Pelotensian entity, did a qualitative research whose purpose is to develop sports activities as a form of social inclusion. To that end, we used two different techniques, the focus group and semi-structured. Th
Publicado em: 2008
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4. O receptor sensor de cálcio e doenças associadas
O receptor sensor de cálcio (CASR) ajusta o set point do cálcio extracelular através da regulação da secreção de PTH e da excreção renal de cálcio. O receptor é expresso em diversos tecidos e também está envolvido em outras funções celulares como proliferação, diferenciação e secreção de outros hormônios. Concentrações altas de cálci
Arquivos Brasileiros de Endocrinologia & Metabologia. Publicado em: 2006-08
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5. Expressão do receptor sensor de calcio com mutações e deleção no dominio extracelular
The calcium sensing receptor (CASR) is a member of the family III of G protein coupled receptors and plays an essential role in calcium homeostasis. The extracellular domain (ECD) of the receptor is the most important site for Ca/+-binding and the majority of the naturally occurring mutations in the ECD affects only the affinity of the receptor for Cao2+. Ot
Publicado em: 2004
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6. Expressão do receptor sensor de calcio com mutações no dominio transmembrana
Introdução: O receptor sensor de cálcio (CASR)pertence à famíliados receptores que acoplam à proteínaG e possui homologiacom a subfamíliados receptores metabotrópicos do glutamato.Ele é importante no processo de homeostase do cálcio,e quando a concentração de cálcio se eleva,ele inibe a secreção de paratonnônio pelas paratireóidese a reabso
Publicado em: 2004
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7. Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background
To understand the role of the calcium-sensing receptor (CasR) in the skeleton, we used a genetic approach to ablate parathyroid glands and remove the confounding effects of elevated parathyroid hormone (PTH) in CasR-deficient mice. CasR deficiency was transferred onto the glial cells missing 2–deficient (Gcm2-deficient) background by intercrossing CasR- an
American Society for Clinical Investigation.
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8. Pharmacochaperone-Mediated Rescue of Calcium-Sensing Receptor Loss-of-Function Mutants
The calcium sensing receptor (CaSR) is a Family C/3 G protein-coupled receptor that translates changes in extracellular Ca2+ into diverse intracellular signals. Loss-of-function mutations in human CaSR cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. CaSR must navigate a number of endoplasmic reticulum quality control check
The Endocrine Society.
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9. Regulation of murine fetal-placental calcium metabolism by the calcium-sensing receptor.
The calcium-sensing receptor (CaSR) regulates PTH secretion to control the extracellular calcium concentration in adults, but its role in fetal life is unknown. We used CaSR gene knockout mice to investigate the role of the CaSR in regulating fetal calcium metabolism. The normal calcium concentration in fetal blood is raised above the maternal level, an incr
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10. The Corpuscles of Stannius, Calcium-Sensing Receptor, and Stanniocalcin: Responses to Calcimimetics and Physiological Challenges
This study has examined whether the calcium-sensing receptor (CaSR) plays a role in control of stanniocalcin-1 (STC-1), the dominant calcium regulatory hormone of fish, comparable with that demonstrated for CaSR in the mediation of ionized calcium regulation of PTH secretion in mammals. In a previous study, we have cloned flounder STC-1 from the corpuscles o
The Endocrine Society.
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11. Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification
The extracellular calcium-sensing receptor (CaSR) plays a pivotal role in the regulation of extracellular calcium such that abnormalities, which result in a loss or gain of function, lead to hypercalcemia or hypocalcemia, respectively, in patients. Mice carrying CaSR knockout alleles develop hypercalcemia that mimics the disorders observed in humans. To date
National Academy of Sciences.
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12. Calcium sensing receptor: molecular cloning in rat and localization to nerve terminals.
We have molecularly cloned a calcium sensing receptor (CaSR) from a rat striatal cDNA library. Rat CaSR displays 92% overall homology to its bovine counterpart with seven putative transmembrane domains characteristic of the superfamily of guanine nucleotide-binding proteins and significant homology with the metabotropic glutamate receptors. Northern blot ana