Carbon Tetrachloride
Mostrando 1-12 de 135 artigos, teses e dissertações.
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1. Micellar propolis nanoformulation of high antioxidant and hepatoprotective activity
ABSTRACT The present study reports a promising antioxidant protection by a recently developed micellar propolis formulation, against oxidative stress in in vitro and in vivo models of toxicity. The formulation, based on poplar propolis encapsulated in poly(ethylene oxide)–β-poly(propylene oxide)–β-poly(ethylene oxide) triblock copolymer (PEO26–PPO40�
Rev. bras. farmacogn.. Publicado em: 26/08/2019
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2. Alcesefoliside protects against oxidative brain injury in rats
ABSTRACT This study investigated the possible antioxidant and neuroprotective effects of alcesefoliside, isolated from Astragalus monspessulanus L., Fabaceae, against carbon tetrachloride (CCl4)-induced brain injury in Wistar rats. Iron sulphate/ascorbic acid lipid peroxidation was induced in rat brain microsomes and pre-incubated with alcesefoliside and sil
Rev. bras. farmacogn.. Publicado em: 27/05/2019
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3. Swertiamarin attenuates carbon tetrachloride (CCl4)-induced liver injury and inflammation in rats by regulating the TLR4 signaling pathway
The aim of the present study is to illustrate the effects of swertiamarin (STM), a natural iridoid from herbal medicines, on hepatic inflammation induced by carbon tetrachloride (CCl4) in rats. Male Sprague Dawley rats were exposed to CCl4 with or without STM co-administration for 8 weeks. Our results revealed that STM administration (100 and 200 mg/kg b.w.
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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4. Feasibility of DLLME for the Extraction and Preconcentration of As and Cd in Sugar for Further Determination by ICP-MS
A method for determining low levels of As and Cd by dispersive liquid-liquid microextraction (DLLME) and inductively coupled plasma mass spectrometry (ICP-MS) was proposed. The following parameters that affect extraction efficiency were investigated: type and volume of extraction solvent (1000 µL acetone), type and volume of dispersive solvent (75 µL carbo
J. Braz. Chem. Soc.. Publicado em: 2017-09
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5. Hepatic Osteodystrophy: The Mechanism of Bone Loss in Hepatocellular Disease and the Effects of Pamidronate Treatment
OBJECTIVES: The present study was designed to evaluate the bone phenotypes and mechanisms involved in bone disorders associated with hepatic osteodystrophy. Hepatocellular disease was induced by carbon tetrachloride (CCl4). In addition, the effects of disodium pamidronate on bone tissue were evaluated. METHODS: The study included 4 groups of 15 mice: a) C
Clinics. Publicado em: 2017-04
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6. Down-Regulation of NFkB, Bax,TGF-β, Smad-2mRNA expression in the Livers of Carbon Tetrachloride Treated Rats using Different Natural Antioxidants
The objective of this study is to examine whether silymarin alone or in combination with chlorogenic acid and/ or melatonin plays a modulatory role against apoptotic damage in rats liver induced by of CCl4. The present work revealed that CCl4 induced elevation of in Bax, Smad, TGF-β and NFkBhepatic mRNA expression, administration of silymarin alone down reg
Braz. arch. biol. technol.. Publicado em: 22/03/2016
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7. Assessment of the Potential Role of Silymarin Alone or in Combination with Vitamin E and/ or Curcumin on the Carbon Tetrachloride Induced Liver Injury in Rat
ABSTRACT The aim of this study was to investigate the effective role of silymarin either alone or in a combination with vitamin E and/or curcumin against the toxic impact of carbon tetrachloride (CCl4) induced liver injury The results revealed that administration of silymarin alone or in a combination with vitamin E and/or curcumin for 21 consecutive days, 2
Braz. arch. biol. technol.. Publicado em: 2015-12
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8. Bark Extract of Bathysa cuspidata in the Treatment of Liver Injury Induced by Carbon Tetrachloride in Rats
The aim of this study was to investigate the effect of bark extract Bathysa cuspidata (BCE) in the reconstitution of hepatic parenchyma and stroma after dysfunction induced by the CCl4. Liver lesions were induced by intraperitoneal administration of CCl4 (1 mL/kg) every 48 h for 12 days. The animals were treated with B. cuspidata extract (BCE) administered b
Braz. arch. biol. technol.. Publicado em: 2014-08
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9. Spectrophotometric determination of Sudan Blue II in environmental samples after dispersive liquid-liquid microextraction
A dispersive liquid-liquid microextraction procedure coupled to spectrophotometry is described for the determination of the trace levels of Sudan Blue II. Analytical parameters, such as pH, volume of extraction solvent (carbon tetrachloride), volume of dispersant (ethanol), volume of sample, and extraction time, were optimized. Matrix effects were also inves
Quím. Nova. Publicado em: 2014
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10. Effect of decaffeination of green and roasted coffees on the in vivo antioxidant activity and prevention of liver injury in rats
Decaffeination and roasting affects the composition of the chlorogenic acids in coffee, which have antioxidant potential. The aim of this study was to evaluate the effects of coffee decaffeination on the in vivo antioxidant activity and the prevention of liver damage. The Wistar rats received intraperitoneal doses of carbon tetrachloride and daily doses of A
Rev. bras. farmacogn.. Publicado em: 14/05/2013
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11. Efeito do Ácido Gálico sobre a fibrogênese hepática murina / Effect of Gallic Acid in murine hepatic fibrogenesis
The fibrogenic processes activate by mechanisms such as oxidative stress can lead to a picture of liver cirrhosis, which represents a major cause of death in West. However, in some studies, phenolic substances, such as Gallic Acid (GA) shown to inhibit and even regress theses processes. The aim of this study was to investigate the effects of the phenolic com
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/04/2012
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12. Hepatoprotective efficacy of Hypnea muciformis ethanolic extract on CCl4 induced toxicity in rats
The ethanolic extract of Hypnea muciformis (red algae) was tested for hepatoprotective activity against experimentally induced liver damage by Carbon tetrachloride (CCl4) in male albino rats. The levels of serum enzymatic and biochemical parameters such as serum glutamate oxaloacetate transaminase (SGOT), Serum glutamate pyruvate transaminase (SGPT), alkalin
Braz. arch. biol. technol.. Publicado em: 2012-12