Carbon Tetrachloride
Mostrando 13-24 de 135 artigos, teses e dissertações.
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13. The influence of organic solvents on estimates of genotoxicity and antigenotoxicity in the SOS chromotest
In this work, the toxicity and genotoxicity of organic solvents (acetone, carbon tetrachloride, dichloromethane, dimethylsulfoxide, ethanol, ether and methanol) were studied using the SOS chromotest. The influence of these solvents on the direct genotoxicity induced by the mutagens mitomycin C (MMC) and 4-nitroquinoline-1-oxide (4-NQO) were also investigated
Genetics and Molecular Biology. Publicado em: 2012
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14. Dispersive liquid-liquid microextraction for the simultaneous separation of trace amounts of zinc and cadmium ions in water samples prior to flame atomic absorption spectrometry determination
In the proposed method, carbon tetrachloride and ethanol were used as extraction and dispersive solvents. Several factors that may be affected on the extraction process, such as extraction solvent, disperser solvent, the volume of extraction and disperser solvent, pH of the aqueous solution and extraction time were optimized. Under the optimal conditions, li
Química Nova. Publicado em: 2012
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15. The effect of down-regulation of Smad3 by RNAi on hepatic stellate cells and a carbon tetrachloride-induced rat model of hepatic fibrosis
Searching for effective Smad3 gene-based gene therapies for hepatic fibrosis, we constructed siRNA expression plasmids targeting the rat Smad3 gene and then delivered these plasmids into hepatic stellate cells (HSCs). The effect of siRNAs on the mRNA levels of Smad2, Smad3, Smad4, and collagens I-α1, III-α1 and IV-α1 (Colα1, Col3α1, Col4α1, respectivel
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-02
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16. Angiogenesis and experimental hepatic fibrosis
Angiogenesis is a basic change occurring during repair by granulation tissue. This process seems to precede fibrosis formation in most types of chronic liver disease. To examine its presence and significance in different types of hepatic insults, this paper sought to identify the presence, evolution and peculiarities of angiogenesis in the most common experi
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-08
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17. Estudo da eficiência de degradação de tetracloreto de carbono por plasma térmico e caracterização dos produtos formados
Decomposition of carbon tetrachloride in a DC thermal plasma reactor was investigated in argon atmosphere. The operational parameters such as plasma torch power and argon flow rate versus CCl4 conversion were examined. The CCl4 net degradation was determined by GC-FID, the chlorine produced was quantified by iodometric titration, the solid carbon was charact
Química Nova. Publicado em: 2010
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18. Potentiation of carbon tetrachloride hepatotoxicity by pentosan polysulfate in rats
Few data are available in the literature regarding the effect of pentosan polysulfate (PPS) on normal and fibrotic rat livers. In addition, the combination of PPS and carbon tetrachloride (CCl4) has not been studied so far. The objective of this study was to assess the effect of PPS on rat livers treated or not with CCl4 for the induction of liver fibrosis.
Publicado em: 2010
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19. Proteção antioxidante da quercetina em fígado de ratos cirróticos
O uso de tetracloreto de carbono (CCl4) em ratos é um modelo experimental de dano ao tecido hepático, desencadeando fibrose e, a longo prazo, cirrose. Seu metabolismo ocorre no fígado pelo citocromo P450, resultando na produção de radicais livres e estimulação da lipoperoxidação, que induz um processo de necrose, inflamação e maior progressão da
Publicado em: 2010
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20. SIMULTANEOUS DETERMINATION OF ORGANIC COMPOUND RESIDUES IN WATER SAMPLES BY DISPERSIVE LIQUIDLIQUID MICROEXTRACTION (DLLME) AND GC-(TQ)MS/MS / DETERMINAÇÃO DE RESÍDUOS DE COMPOSTOS ORGÂNICOS EM ÁGUA POR MICROEXTRAÇÃO LÍQUIDO-LÍQUIDO DISPERSIVA (DLLME) E GC-(TQ)MS/MS
The use of chemicals, which generates a lot off benefits, is responsible for the contamination of soil, water and foods. The concern about contamination of surface and ground water systems by pesticides has grown in scientific circles, especially by the presence of pesticides and other compounds in water sources. Thus, rapid analytical methods, sensitive and
Publicado em: 2010
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21. An ultrasound and histomorphological analysis of experimental liver cirrhosis in rats
We investigated whether liver injury by dual exposure to ethanol and carbon tetrachloride (EtOH + CCl4) for 15 weeks would persist after hepatotoxic agents were removed (EtOH + CCl4/8wR). After 15 weeks of hepatic injury with ethanol (5.5%, m/v) and carbon tetrachloride (0.05, mL/kg, ip), 5 of 11 female Wistar rats were sacrificed. The other 6 rats were main
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-11
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22. Efeito da descafeinaÃÃo do cafà sobre a atividade antioxidante e prevenÃÃo de lesÃo hepÃtica em ratos / Effect of decaffeination of coffee on the antioxidant activity and prevention of liver injury in rats
The present study aimed at evaluating the effect of the coffee decaffeination on the antioxidant activity in vitro and in vivo and on the prevention of liver injury in rats. In all experiments the beverages was prepared according to a same methodology. There were certain the content of phenolic compounds, chlorogenic acids, caffeine, trigonelline and soluble
Publicado em: 2008
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23. EFFECTS OF DIPHENYL DISELENIDE ADMINISTRATION ON LIVER DAMAGE INDUCED BY 2-NITROPROPANE, CADMIUM AND CARBON TETRACHLORIDE / EFEITOS DA ADMINISTRAÇÃO DO DISSELENETO DE DIFENILA SOBRE O DANO HEPÁTICO INDUZIDO POR 2-NITROPROPANO, CÁDMIO E TETRACLORETO DE CARBONO
O fígado apresenta extraordinária pluralidade funcional, destacando-se no controle de produção de energia, defesa imunológica e reserva volêmica. No meio ambiente e ocupacionalmente, o ser humano está exposto a uma variedade de compostos hepatotóxicos, como por exemplo, no uso de tintas e seus derivados (2-nitropropano), reagentes químicos (tetraclo
Publicado em: 2008
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24. Male gonadal function, prolactin secretion and lactotroph population in an experimental model of cirrhosis
Liver cirrhosis, a highly prevalent chronic disease, is frequently associated with endocrine dysfunctions, notably in the gonadal axis. We evaluated lactotroph population by immunohistochemistry, gonadotropins and prolactin by immunoradiometric assay and testosterone and estradiol by radioimmunoassay in adult male Wistar rats with cirrhosis induced by carbon
Brazilian Journal of Medical and Biological Research. Publicado em: 31/07/2007