Bmal1
Mostrando 1-12 de 28 artigos, teses e dissertações.
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1. The expression of melanopsin and clock genes in Xenopus laevis melanophores and their modulation by melatonin
Vertebrates have a central clock and also several peripheral clocks. Light responses might result from the integration of light signals by these clocks. The dermal melanophores of Xenopus laevis have a photoreceptor molecule denominated melanopsin (OPN4x). The mechanisms of the circadian clock involve positive and negative feedback. We hypothesize that these
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-08
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2. Relógios biológicos e padrões de alimentação em camundongos normais e com sobrepeso / Biological clocks and feeding patterns in normal mice and overweight
A saudável interação entre o indivíduo e o meio depende do alinhamento entre a dinâmica fisiológica do primeiro e os periódicos movimentos da natureza. A interação entre tais ritmos por sua vez constitui-se em base e derivação do processo de evolução. O comprometimento de tal alinhamento representa um risco para a sobrevivência das espécies. N
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/06/2011
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3. Interactions of polymorphisms in different clock genes associated with circadian phenotypes in humans
Several studies have shown that mutations and polymorphisms in clock genes are associated with abnormal circadian parameters in humans and also with more subtle non-pathological phenotypes like chronotypes. However, there have been conflicting results, and none of these studies analyzed the combined effects of more than one clock gene. Up to date, associatio
Genetics and Molecular Biology. Publicado em: 12/11/2010
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4. Modulação da expressão dos genes para melanopsina, clock, per1, per2 e bmal1 por melatonina em melanóforos dérmicos do anfíbio Xenopus laevis / Modulation of the expression of melanopsin, clock, per1, per2 e bmal1 , and by melatonin in dermal melanophores of Xenopus laevis
O ritmo diário de atividade é uma característica de todos os organismos vivos, que tem a capacidade de se orientar no tempo e no espaço, e distinguir entre tempo linear e tempo cíclico. O ciclo claro:escuro é um importante indicador circadiano para todos os organismos. O trabalho do relógio circadiano envolve mecanismos de retroalimentação positiva
Publicado em: 2008
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5. Serotonergic system - Interactions with the circadian timing system. / Sistema serotonérgico - relações com o sistema de temporização circadiano.
Componente essencial do sistema de temporização circadiano, o núcleo supraquiasmático (NSQ) possui três aferências principais: o trato retinohipotalâmico (TRH), o trato geniculohipotalâmico (TGH) e as terminações serotonérgicas da rafe. Suas células possuem oscilação circadiana autônoma que resultam na expressão rítmica dos chamados genes do
Publicado em: 2007
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6. Modulação dos genes de relógio Per1, Cry1b, Clock e da melanopsina por endotelina-1 em células embrionárias de Danio rerio / Modulation of clock genes Per1, Cry1b, Clock and of melanopsin by endothelin-1 in Danio rerio embryonic cells
Biological clocks are endogenous timekeepers that are present both in eukaryotic as in prokaryotic organisms. Different clocks have different periods, and those that have about 24h of oscillation are called circadian clocks. In mammals, the first identified circadian clock is located in the suprachiasmatic nucleus, in the hipothalamus. It is now well known t
Publicado em: 2007
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7. Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis
Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. Here, we established its involvement in the control of adipogenesis and lipid metabolism activity in mature adipocytes. During adipose differentiation in 3T3-L1 cells, the level of BMAL1 mRNA began to increase 4 days after i
National Academy of Sciences.
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8. Preferential Inhibition of BMAL2-CLOCK Activity by PER2 Reemphasizes Its Negative Role and a Positive Role of BMAL2 in the Circadian Transcription*
In the molecular oscillatory mechanism governing circadian rhythms, positive regulators, including CLOCK and BMAL1, transactivate Per and Cry genes through E-box elements, and translated PER and CRY proteins negatively regulate their own transactivation. Like BMAL1, its paralog BMAL2 dimerizes with CLOCK to activate the E-box-dependent transcription, but the
American Society for Biochemistry and Molecular Biology.
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9. Herpes simplex virus 1 α regulatory protein ICP0 functionally interacts with cellular transcription factor BMAL1
The infected cell protein no. 0 (ICP0) of herpes simplex virus 1 (HSV-1) is a promiscuous transactivator shown to enhance the expression of gene introduced into cells by infection or transfection. At the molecular level, ICP0 is a 775-aa ring finger protein localized initially in the nucleus and late in infection in the cytoplasm and mediates the degrad
The National Academy of Sciences.
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10. BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose Homeostasis
Circadian timing is generated through a unique series of autoregulatory interactions termed the molecular clock. Behavioral rhythms subject to the molecular clock are well characterized. We demonstrate a role for Bmal1 and Clock in the regulation of glucose homeostasis. Inactivation of the known clock components Bmal1 (Mop3) and Clock suppress the diurnal va
Public Library of Science.
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11. BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system
Mammalian CLOCK and BMAL1 are two members of bHLH-PAS-containing family of transcription factors that represent the positive elements of circadian autoregulatory feedback loop. In the form of a heterodimer, they drive transcription from E-box enhancer elements in the promoters of responsive genes. We have examined abundance, posttranslational modificatio
Cold Spring Harbor Laboratory Press.
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12. Asynchronous oscillations of two zebrafish CLOCK partners reveal differential clock control and function
Most clock genes encode transcription factors that interact to elicit cooperative control of clock function. Using a two-hybrid system approach, we have isolated two different partners of zebrafish (zf) CLOCK, which are similar to the mammalian BMAL1 (brain and muscle arylhydrocarbon receptor nuclear translocator-like protein 1). The two homologs, zfBMAL1 an
The National Academy of Sciences.