Biological Signaling Network
Mostrando 1-12 de 28 artigos, teses e dissertações.
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1. From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases
Abstract The DNA Damage Response (DDR) is a complex network of biological processes that protect cells from accumulating aberrant DNA structures, thereby maintaining genomic stability and, as a consequence, preventing the development of cancer and other diseases. The DDR pathway is coordinated by a signaling cascade mediated by the PI3K-like kinases (PIKK) A
Genet. Mol. Biol.. Publicado em: 13/12/2019
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2. Genome-wide DNA methylation profile in the peripheral blood of cocaine and crack dependents
Objective: Cocaine use disorders (CUDs) represent a major public health problem in many countries. To better understand the interaction between the environmental modulations and phenotype, the aim of the present study was to investigate the DNA methylation pattern of CUD patients, who had concomitant cocaine and crack dependence, and healthy controls. Meth
Braz. J. Psychiatry. Publicado em: 16/05/2019
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3. Network analysis of ABA-dependent and ABA-independent drought responsive genes in Arabidopsis thaliana
Abstract Drought is one of the most severe abiotic factors restricting plant growth and yield. Numerous genes functioning in drought response are regulated by abscisic acid (ABA) dependent and independent pathways, but knowledge of interplay between the two pathways is still limited. Here, we integrated transcriptome sequencing and network analyses to explor
Genet. Mol. Biol.. Publicado em: 23/07/2018
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4. Transduction motif analysis of gastric cancer based on a human signaling network
To investigate signal regulation models of gastric cancer, databases and literature were used to construct the signaling network in humans. Topological characteristics of the network were analyzed by CytoScape. After marking gastric cancer-related genes extracted from the CancerResource, GeneRIF, and COSMIC databases, the FANMOD software was used for the min
Braz J Med Biol Res. Publicado em: 04/04/2014
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5. Systems biology approach to study the high altitude adaptation in tibetans
The aim of this work was to study an integrative systems biology research strategy to construct a network including the protein-protein interactions (PPIs) and microRNAs (miRNAs) and identify the functional biological processes and pathways for high-altitude adaptation in Tibetans. The pathway enrichment analysis revealed that the genes in the network were m
Braz. arch. biol. technol.. Publicado em: 2013-02
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6. Sistemas de partículas interagentes dependentes de tipo e aplicações ao estudo de redes de sinalização biológica / Type-dependent interacting particle systems and their applications in the study of signaling biological networks
We study type-dependent stochastic spin models proposed by Fernández et al., which were used to model biological signaling networks. The original modeling setup describes the macroscopic evolution of a finite-size spin-flip model with k types of spins with arbitrary number of internal states interacting through a non-reversible stochastic dynamics. In the t
Publicado em: 2011
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7. Transcriptional networks reconstruction: identification of genes involved on cattle response to tick Rhipicephalus (Boophilus) microplus infestation.
In tropical countries, losses caused by tick infestation in cattle lead to a great impact on animal production systems. Weight and feed conversion reduction, together with diseases transmitted by the parasite are some of the problems that lead to economic losses of billion dollars a year. In a general way, Bos taurus indicus cattle are less susceptible to in
INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY. Publicado em: 2011
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8. Analysis diferential gene expression of skeletal muscular cells from a primary culture infected with tackyzoites of toxoplasma gondii. / Análise diferencial da expressão gênica de cultura primária de células musculares esqueléticas durante a infecção com taquisoítos de toxoplasma gondii.
The microarray technique is a powerful tool to analyze the changes in gene expression occurring during an infectious process caused by a pathogen. This work aims to study the biological process of interaction between a host cell and an intracellular parasite, Toxoplasma gondii, at a transcriptional level, using a high density microarray (Genechip) Samples we
Publicado em: 2006
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9. Functional Proteomics Mapping of a Human Signaling Pathway
Access to the human genome facilitates extensive functional proteomics studies. Here, we present an integrated approach combining large-scale protein interaction mapping, exploration of the interaction network, and cellular functional assays performed on newly identified proteins involved in a human signaling pathway. As a proof of principle, we studied the
Cold Spring Harbor Laboratory Press.
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10. Proteome-wide Prediction of Signal Flow Direction in Protein Interaction Networks Based on Interacting Domains*
Signal flow direction is one of the most important features of the protein-protein interactions in signaling networks. However, almost all the outcomes of current high-throughout techniques for protein-protein interactions mapping are usually supposed to be non-directional. Based on the pairwise interaction domains, here we defined a novel parameter protein
The American Society for Biochemistry and Molecular Biology.
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11. An expanded view of bacterial DNA replication
A protein-interaction network centered on the replication machinery of Bacillus subtilis was generated by genome-wide two-hybrid screens and systematic specificity assays. The network consists of 91 specific interactions linking 69 proteins. Over one fourth of the interactions take place between homologues of proteins known to interact in other organisms, in
The National Academy of Sciences.
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12. Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips
The TOR (target of rapamycin) proteins play important roles in nutrient signaling in eukaryotic cells. Rapamycin treatment induces a state reminiscent of the nutrient starvation response, often resulting in growth inhibition. Using a chemical genetic modifier screen, we identified two classes of small molecules, small-molecule inhibitors of rapamycin (SMIRs)
National Academy of Sciences.