From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases
AUTOR(ES)
Cussiol, José Renato Rosa
FONTE
Genet. Mol. Biol.
DATA DE PUBLICAÇÃO
13/12/2019
RESUMO
Abstract The DNA Damage Response (DDR) is a complex network of biological processes that protect cells from accumulating aberrant DNA structures, thereby maintaining genomic stability and, as a consequence, preventing the development of cancer and other diseases. The DDR pathway is coordinated by a signaling cascade mediated by the PI3K-like kinases (PIKK) ATM and ATR and by their downstream kinases CHK2 and CHK1, respectively. Together, these kinases regulate several aspects of the cellular program in response to genomic stress. Much of our understanding of these kinases came from studies performed in the 1990s using yeast as a model organism. The purpose of this review is to present a historical perspective on the discovery of the DDR kinases in yeast and the importance of this model for the identification and functional understanding of their mammalian orthologues.
Documentos Relacionados
- Evolution of the primate lineage leading to modern humans: Phylogenetic and demographic inferences from DNA sequences
- Immune Response to Recombinant Adenovirus in Humans: Capsid Components from Viral Input Are Targets for Vector-Specific Cytotoxic T Lymphocytes
- Novel roles for A-type lamins in telomere biology and the DNA damage response pathway
- Corticospinal direct response in humans: identification of the motor cortex during intracranial surgery under general anaesthesia.
- The new dysmorphology: application of insights from basic developmental biology to the understanding of human birth defects.