Biodegradable Microparticles
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Developing a Mathematical Model for the Controlled Release Over Time of Sulfentrazone Herbicide from Biodegradable Polymer
In our research group, controlled release systems for the sulfentrazone herbicide has been accomplished by encapsulating this bioactive compound into calcium alginate (Ca-ALG) biodegradable polymer fashion and the release mechanisms were verified by using Korsmeyer-Peppas model (KP). However, the KP model does not allow to evaluate all the phenomena involved
Mat. Res.. Publicado em: 11/11/2019
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2. POLÍMERO BIODEGRADÁVEL ANTIMICROBIANO ATRAVÉS DA ADITIVAÇÃO COM COMPOSTOS À BASE DE ZINCO
Antimicrobial packaging is a promising type of active packaging, which has an antimicrobial agent incorporated into the polymer matrix, capable to eliminate or inhibit deteriorating and/or pathogenic microorganisms. The zinc compounds are antimicrobial agents commonly used to confer this feature. The objective of this work was to evaluate the antimicrobial a
Quím. Nova. Publicado em: 2018-04
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3. HPLC-DAD and UV-Vis Spectrophotometric Methods for Methotrexate Assay in Different Biodegradable Microparticles
The challenge of the present work concerned the development and validation of high performance liquid chromatography (HPLC) and UV-Vis spectrophotometric methods for quantitation of methotrexate (MTX) loaded on biodegradable microparticles, composed of copolymers with different solubilities such as chitosan and poly (lactic-co-glycolic acid) (PLGA). The line
J. Braz. Chem. Soc.. Publicado em: 2015-04
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4. Micropartículas de poli (ácido lático-co-ácido glicólico) obtidas por spray drying para a liberação prolongada de metotrexato
O metotrexato (MTX) é um fármaco utilizado na quimioterapia de alguns tipos de câncer, doenças autoimunes e uveítes não inflamatórias resistentes aos corticosteróides. No entanto, sua rápida eliminação plasmática limita o sucesso terapêutico, levando à necessidade de altas doses para manutenção da concentração efetiva no tecido alvo, ocasio
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/12/2011
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5. Spray-drying: process specifications in manufacturing dental drug loaded-biodegradable microparticles for sustained release purposes / Determinação das especifícações do processo spray dryingna obtenção de micropartículas biodegradaveis para liberação sustentada de princípios ativos com aplicações odontógica.
A liberação local de fármacos na cavidade oral apresenta muitas aplicações, incluindo o controle da dor pós-cirúrgica, tratamento de doenças periodontais e anestesia local. Micropartículas carregadas com anti-inflamatórios não-esteroidais (AINEs) produzidas para a liberação sustentada é útil em Odontologia, uma vez que mantém o fármaco em n�
Publicado em: 2005
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6. Single-Dose Mucosal Immunization with Biodegradable Microparticles Containing a Schistosoma mansoni Antigen
The purpose of this work was to assess the immunogenicity of a single nasal or oral administration of recombinant 28-kDa glutathione S-transferase of Schistosoma mansoni (rSm28GST) entrapped by poly(lactide-co-glycolide) (PLG)- or polycaprolactone (PCL)-biodegradable microparticles. Whatever the polymer and the route of administration used, the equivalent of
American Society for Microbiology.
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7. Cationic microparticles: A potent delivery system for DNA vaccines
An approach involving the preparation of biodegradable microparticles with a cationic surface was developed to improve the delivery of adsorbed DNA into antigen-presenting cells after i.m. injection. The microparticles released intact and functional DNA over 2 weeks in vitro. In addition, the microparticles induced higher levels of marker gene expression in
The National Academy of Sciences.
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8. Studies on Mefenamic Acid Microparticles: Formulation, In Vitro Release, and In Situ Studies in Rats
In this study, we investigated the in vitro characteristics of mefenamic acid (MA) microparticles as well as their effects on DNA damage. MA-loaded chitosan and alginate beads were prepared by the ionotropic gelation process. Microsponges containing MA and Eudragit RS 100 were prepared by quasi-emulsion solvent diffusion method. The microparticles were chara
Springer US.
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9. Formulation of anastrozole microparticles as biodegradable anticancer drug carriers
The purpose of this study was to develop poly(d,1-lactic-coglycolic acid) (PLGA)-based anastrozole microparticles for treatment of breast cancer. An emulsion/extraction method was used to prepare anastrozole sustained-release PLGA-based biodegradable microspheres. Gas chromatography with mass spectroscopy detection was used for the quantitation of the drug t
Springer-Verlag.
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10. Particle uptake and translocation across epithelial membranes.
Oral delivery of drugs and vaccines has many advantages over other routes of administration. For example, for vaccination, enteric delivery may result in the induction of a mucosal immune response against pathogens which colonise and invade the mucosa. However, the oral delivery of peptide or protein drugs or antigens is beset with problems, such as gastroin
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11. Examination of aqueous oxidized cellulose dispersions as a potential drug carrier: II. In vitro and in vivo evaluation of phenylpropanolamine release from microparticles and pellets
The purpose of this research is to investigate the release of phenylpropanolamine from oxidized cellulose-phenylpropanolamine (OC-PPA) complexes prepared using aqueous OC dispersions (degree of neutralization, DN, 0–0.44) and phenylpropanolamine-hydrochloride (PPA.HC1) (concentration, 0.5 M or 1.4 M) in vitro and in vivo. The results showed a faster drug r
Springer-Verlag.
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12. Spray-dried poly(D,L-lactide) microspheres containing carboplatin for veterinary use: In vitro and in vivo studies
The aim of this study was the development of a veterinary dosage form constituted by injectable biodegradable microspheres designed for the subcutaneous release of carboplatin, a chemotherapeutic drug. Poly(D,L-lactide) (PDLLA) microspheres were prepared by an emulsification/spray-drying method, using the drug-to-polymer weight ratios 1∶9 and 1∶5; blank
Springer-Verlag.