Tratamento conservador do carcinoma mamario : estadios I e II

AUTOR(ES)
DATA DE PUBLICAÇÃO

1990

RESUMO

From 1981 to 1988, 265 patients with breast cancer stages I and II (UICC-1987), were evaluated after conservative treatment with quadrantectomy plus axillectomy, radiotherapy and chemotherapy. After surgical treatment, the patients were submitted to radiation therapy in the breast, receiving megavoltage with cobalt-60 or 4 Me V linear accelerator and a total dose of 5.000 cGy in 5 weeks. The quadrantectomy scar received an extra dose of 1.000 cGy in 1 week on orthovoltage. One hundred and fifty six (58,8%) patienls were submitted to adjuvant chemotherapy, 6 CMF cycles in a 21-day-interval. The median clinical follow-up period was 42.8 months with a minimum of 24 and a maximum of 99 months. Six (2,3%) patients presented local recurrence and 48 (18,1 %) presented distant metastasis. After five years the total survival rate was 89,7% and the disease free survival rate was 75% in the same period. The study did not show significant differences among the clinical stages classified after surgery and the use of adjuvant chemotherapy did not influence the results of the many stages. The period of time until disease recurrence was considered as a dependent variable, and many independent variables such as: age, menstrual condition, histologic type, clinical stage, histopathologic stage, nuclear grade, use of chemotherapy, breast tumor site, local recurrence and the period between biopsy and surgery. The most important independently linked variable during all the analysis was the histologic grade (p <0,003). About 60% of the patients had good cosmetic results.

ASSUNTO(S)

mamas - cancer radioterapia

ACESSO AO ARTIGO

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