Toxoplasmose ocular: nÃveis de IgA secretora especÃfica na lÃgrima de pacientes na fase ativa e inativa da doenÃa

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Introduction: Ocular toxoplamosis is caused by the protozoan Toxoplasma gondii that leads to recurrent uveitis. Its clinical diagnosis is often confused with other types of uveitis. Studies have shown that there is an association between active ocular toxoplasmosis and the presence of IgAs anti-T. gondii in tears. Objective: To compare the level of IgAs anti-T. gondii in tears of patients with toxoplasmic uveitis during acute phase versus inactive phase of the disease. Methods: There were selected 29 patients with acute toxoplasmic uveitis who presented positive for the specific IgAs in tears. These patients were followed by a minimum period of two years. After that, the IgAs anti-T. gondii level was measured and compared with the acute phase level. Results: The specific IgAs was negative in 22 patients (75.56%) and positive in 7 patients (24.13%). Among the latter, six patients (85.7%) had a follow up period up to three years. The decrease in the acute phase IgAs mean value from 1,53 to the inactive phase value of 0,73 was significant (p=0,0001). Conclusions: IgAs anti-T. gondii of tears was negative in 75,56% of patients after the disease acute phase enabling this marker to be used for the diagnosis of active ocular toxoplasmosis

ASSUNTO(S)

toxoplasmose ocular medicina iga secretora secretory iga lÃgrima ocular toxoplasmosis uveitis tear uveÃte

ACESSO AO ARTIGO

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