Spray drying of Eugenia dysenterica extract: effects of in-process parameters on product quality
AUTOR(ES)
Couto, Renê O., Martins, Frederico S., Chaul, Luiza T., Conceição, Edemilson C., Freitas, Luis Alexandre P., Bara, Maria Teresa F., Paula, José R.
FONTE
Rev. bras. farmacogn.
DATA DE PUBLICAÇÃO
18/09/2012
RESUMO
A 2³ full factorial design was used to assess the impact of spraying air flow rate (30-50 L/min), drying air inlet temperature (90-150 ºC) and extract feed rate (4-6 g/min) on the quality of Eugenia dysenterica DC., Myrtaceae, spray-dried extracts. Response surface methodology (RSM) was applied to analyze the significance of the effects of process factors on product quality and to obtain fitted equations to predict dry powder properties. Powder yields were satisfactory, ranging from 34.64 to 63.92%. The dried products showed moisture contents and water activities below 5% and 0.5, respectively. The recuperation ratios of total polyphenols, tannins and flavonoids ranged from 88.66 to 99.07%, 70.38 to 81.87% and 74.51 to 98.68%, respectively. Additionally, in some conditions the parameters related to dry product’s flowability and compressibility varied over a range acceptable for pharmaceutical purposes. RSM proved that studied factors significantly affected most of the quality indicators at different levels. The spray drying technology is an attractive and promising alternative for the development of intermediate phytopharmaceutical products of E. dysenterica.
Documentos Relacionados
- In-process grinding monitoring through acoustic emission
- Fluid bed drying of guarana (Paullinia cupana HBK) extract: Effect of process factors on caffeine content
- Surface topography assessment techniques based on an in-process monitoring approach of tool wear and cutting force signature
- Spouted bed drying of Bauhinia forficata link extract: the effects of feed atomizer position and operating conditions on equipment performance and product properties
- Antioxidant Activity and Metabolomic Analysis of Cagaitas (Eugenia dysenterica) using Paper Spray Mass Spectrometry