Paepalanthus spp: antimycobacterial activity of extracts, methoxylated flavonoids and naphthopyranone fractions

AUTOR(ES)

Moreira, Raquel R. D., Martins, Gilmarcio Z., Pietro, Rosemeire C. L. R., Sato, Daisy N., Pavan, Fernando R., Leite, Sergio R.A., Vilegas, Wagner, Leite, Clarice Q. F.

FONTE

Rev. bras. farmacogn.

DATA DE PUBLICAÇÃO

22/11/2012

RESUMO

Paepalanthus spp., Eriocaulaceae, are native plants from Brazil known as "sempre-vivas" (everlasting flowers). In this work, we evaluated the potential anti-mycobacterial activity of two methoxylated flavonoids (flavonoid 7-methylquercetagetin and 7-methylquercetagetin-4'-O-β-D-glucopyranoside) isolated and identified from P. latipes and the naphthopyranone fractions from P. bromeliodes ethanolic extracts. The MIC value of 500 µg/mL was verified for all compounds tested against M. tuberculosis H37Rv. For M. avium, the MIC value ranged from 1000-2000 µg/mL excepting to naphthopyranone fractions with MIC of 500 µg/mL. This is the first report of activity determination of Paepalanthus spp. flavonoids activity against Mycobacterium tuberculosis and M. avium.

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