Local Anesthetic Activity from Extracts, Fractions and Pure Compounds from the Roots of Ottonia anisum Spreng. (Piperaceae)
AUTOR(ES)
LÓPEZ, KELVIN S.E., MARQUES, ANDRÉ M., MOREIRA, DAVYSON DE L., VELOZO, LEOSVALDO S., SUDO, ROBERTO T., ZAPATA-SUDO, GISELE, GUIMARÃES, ELSIE F., KAPLAN, MARIA AUXILIADORA C.
FONTE
An. Acad. Bras. Ciênc.
DATA DE PUBLICAÇÃO
2016-12
RESUMO
ABSTRACT Piperaceae species can be found worldwide in tropical and subtropical areas and many of them have been used for centuries in traditional folk medicine and in culinary. In Brazil, species of Piperaceae are commonly used in some communities as local anesthetic and analgesic. Countrified communities have known some species of the genus Ottonia as "anestesia" and it is a common habit of chewing leaves and roots of Ottonia species to relief toothache. The purpose of this study is to report our findings on new molecules entities obtained from the roots of Ottonia anisum Spreng, in which local anesthetic activity (sensory blockage) is demonstrated for the first time in vivo guinea pig model. Phytochemical investigation led to the isolation of three amides (pipercallosidine, piperine and valeramide) and in an enriched mixture of seven amides (valeramide, 4,5-dihydropiperlonguminine, N-isobutil-6-piperonil-2-hexenamide, piperovatine, dihydropipercallosidine, pipercallosidine and pipercallpsine). Our findings demonstrated the anesthetic potential for the methanolic extract from roots, its n-hexane partition and amides from O. anisum and it is in agreement with ethnobotanical survey.
Documentos Relacionados
- Investigation of local anesthetic and antimycobacterial activity of Ottonia martiana Miq. (Piperaceae)
- Metabólitos secundários das raízes de Piper crassinervium Kunth (Piperaceae)
- Phytochemical and antibacterial evaluation of essential oils from Ottonia martiana miq. (Piperaceae)
- Seasonal influence and cytotoxicity of extracts, fractions and major compounds from Allamanda schottii
- Three new compounds from Piper montealegreanum Yuncker (Piperaceae)